Regulation of the expression of mouse TAP-associated glycoprotein (tapasin) by cytokines.

abstract：:A considerable body of evidence from various laboratories indicates that specific T cell responses generated during infection with Leishmania parasites play an important role both in the resolution and progression of cutaneous leishmaniasis. Recent data, summarized in this article, indicate that resolution of lesions ...

journal_title：Immunology letters

authors： Müller I,Pedrazzini T,Louis JA

更新日期：1988-11-01 00:00:00

abstract：:T and B cell receptor repertoires are diversified by variable region gene rearrangement and selected based on functionality and lack of self-reactivity. Repertoires can also be defined based on phenotype and function rather than receptor specificity - such as the diversity of T helper cell subsets. Natural killer (NK)...

journal_title：Immunology letters

authors： Mehr R,Sternberg-Simon M,Michaeli M,Pickman Y

更新日期：2012-11-01 00:00:00

abstract：:Pulmonary intraparenchymal leukocytes were purified from normal mice. By flow cytometry, 20-30% of the lymphocytes were positive for the expression of Mac1, a cell-surface antigen largely restricted to macrophages, neutrophils and natural killer (NK) cells. Sorted Mac1+ lung lymphocytes were large and had abundant cyt...

journal_title：Immunology letters

authors： Kawakami K,Teruya K,Tohyama M,Kudeken N,Yonamine Y,Saito A

更新日期：1995-05-01 00:00:00

abstract：:Interleukin 1 beta (IL1 beta) is an inducible polypeptide with many roles in host defence and homoeostasis. It has also been implicated as a mediator of infectious, inflammatory and autoimmune diseases, and the kinetics of its production are relevant to an understanding of the pathogenesis of these conditions. We repo...

journal_title：Immunology letters

authors： di Giovine FS,Symons JA,Duff GW

更新日期：1991-08-01 00:00:00

abstract：:IL-6 mediates its pleiotropic functions through two membrane proteins, a ligand-binding molecule (IL-6 receptor, IL-6R) and a non-ligand-binding signal transducer (gp130). Starting with a previously isolated cDNA clone encoding human gp130, recombinant soluble gp130 (sgp130) lacking the transmembrane and cytoplasmic r...

journal_title：Immunology letters

authors： Yasukawa K,Futatsugi K,Saito T,Yawata H,Narazaki M,Suzuki H,Taga T,Kishimoto T

更新日期：1992-02-01 00:00:00

abstract：:Innate lymphoid cells (ILC) have only recently been recognized as a separate entity of the lymphoid lineage. Their subpopulations share common characteristics in terms of early development and major transcriptional circuitry with their related cousins of the T cell world. It is currently hypothesized that ILCs constit...

journal_title：Immunology letters

authors： Gronke K,Kofoed-Nielsen M,Diefenbach A

更新日期：2016-11-01 00:00:00

abstract：:Toll-like receptors (TLR) are critical in the activation of macrophages by bacterial products. It has been shown that TLR2 and TLR4 mediate lipopolysaccharide (LPS) and lipoproteins signal transduction, respectively. Regulation of TLR2 and TLR4 expression by LPS was considered to be one of the mechanisms to control th...

journal_title：Immunology letters

authors： An H,Xu H,Yu Y,Zhang M,Qi R,Yan X,Liu S,Wang W,Guo Z,Qin Z,Cao X

更新日期：2002-05-01 00:00:00

abstract：:Wnt5a is a secreted pleiotropic glycoprotein produced in an inflammatory state by a wide spectrum of ubiquitous cell populations. Recently, we demonstrated that Wnt5a skews the differentiation of human monocyte derived dendritic cells (moDCs) to a tolerogenic functional state. In this study we focus our interest on th...

journal_title：Immunology letters

authors： Valencia J,Martínez VG,Hidalgo L,Hernández-López C,Canseco NM,Vicente A,Varas A,Sacedón R

更新日期：2014-11-01 00:00:00

abstract：:Molecular chaperones (heat shock proteins, Hsp-s) play a pleiotropic role in immunological functions. Hsp-s participate in the presentation of peptide antigens, folding of several immunologically important proteins, such as the MHC, and in the maintenance of the activation-competent conformation of key signaling molec...

journal_title：Immunology letters

authors： Sreedhar AS,Nardai G,Csermely P

更新日期：2004-03-29 00:00:00

abstract：:Lck is the principal signal-generating tyrosine kinase of the T cell activation mechanism. We have previously demonstrated that induced Lck activation outside of lipid rafts (LR) results in the rapid translocation of a fraction of Lck to LR. While this translocation predicates the subsequent production of IL-2, the me...

journal_title：Immunology letters

authors： Ballek O,Broučková A,Manning J,Filipp D

更新日期：2012-02-29 00:00:00

abstract：:Soluble C3d applied to human blood-derived B lymphocytes inhibited anti-mu, T cell-produced growth factor, and EBV-induced DNA synthesis in serum-free culture. C3d added to the B cell cultures 1 and 2 days after the stimulus, still exerted inhibition, though with gradually diminishing efficiency. C3d, fixed on zymosan...

journal_title：Immunology letters

authors： Kuraya M,Nilsson B,Nilsson-Ekdahl K,Klein E

更新日期：1990-10-01 00:00:00

abstract：:The early thymic precursor population of adult mice (low CD4 precursor) has the potential to produce T cells, B cells and dendritic cells if transferred into the appropriate inductive environment of an irradiated recipient. To assess its developmental potential in vitro, this population was isolated and cultured, alon...

journal_title：Immunology letters

authors： Saunders DJ,Georgiou HM,Wu L,Shortman K

更新日期：1995-07-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase (IDO) is an enzyme with an immunosuppressive effect whose function is diverted by tumor cells to counteract immune cell functions, inducing immune escape of tumor cells. The aim of this study was to investigate the clinical significance of IDO in nasopharyngeal carcinoma (NPC). Compared to ...

journal_title：Immunology letters

authors： Ben-Haj-Ayed A,Moussa A,Ghedira R,Gabbouj S,Miled S,Bouzid N,Tebra-Mrad S,Bouaouina N,Chouchane L,Zakhama A,Hassen E

更新日期：2016-01-01 00:00:00

abstract：:The cell-surface glycoproteins encoded by the major histocompatibility complex (MHC) bind to processed foreign antigens and present them to T lymphocytes. Two classes of MHC molecules and their corresponding gene sequences have been extensively studied in eutherian mammals and birds, but data on the marsupial MHC are ...

journal_title：Immunology letters

authors： Lam MK,Belov K,Harrison GA,Cooper DW

更新日期：2001-02-01 00:00:00

abstract：:Interleukin-18 (IL-18) plays a central role in the immune response by acting on Th1 cell differentiation, cell-mediated cytotoxicity and inflammation. The role of IL-18 in cancers and inflammatory diseases is discussed in the light of our investigations on IL-18 synthesis in normal colonic mucosa, colonic cancer and C...

journal_title：Immunology letters

authors： Pages F,Berger A,Lebel-Binay S,Zinzindohoue F,Danel C,Piqueras B,Carriere O,Thiounn N,Cugnenc PH,Fridman WH

更新日期：2000-12-01 00:00:00

abstract：:An automated biosensor system designed for measuring molecular interactions in real time and without any labelling of the reactants has been used to study the interaction of two animal viruses (vaccinia virus and poliovirus) and two plant viruses (cowpea mosaic virus and tobacco mosaic virus) with monoclonal antibodie...

journal_title：Immunology letters

authors： Dubs MC,Altschuh D,Van Regenmortel MH

更新日期：1992-01-01 00:00:00

abstract：:The surface phenotypes of lymphoid cells in the developing embryonic thymus were characterized by using monoclonal antibodies. FT-2 antigen thus defined was predominantly expressed on thymocytes in the earlier embryonic stages in all the inbred mouse strains tested. The immunofluorescence and immunoperoxidase tests in...

journal_title：Immunology letters

authors： Takashi T,Kasai M,Tanaka N,Takahashi T,Tokunaga T

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Previous studies have reported an association between polymorphisms in Il17A and IL17F genes and the prevalence of rheumatoid arthritis (RA) in Caucasian populations. The aim of the current study was to investigate that polymorphisms in both genes may affect RA susceptibility in the Tunisian population and t...

journal_title：Immunology letters

authors： Marwa OS,Kalthoum T,Wajih K,Kamel H

更新日期：2017-03-01 00:00:00

abstract：:A new method of panning for B lymphocytes is described in which the ability of the sIg+ cells to adhere depends on the nature and concentration of nonspecific protein used rather than on the use of anti-immunoglobulin. Rat lymph node cells were suspended in 3% bovine serum albumin in Tris-buffered Hanks' and incubated...

journal_title：Immunology letters

authors： Severson CD,Burg DL,Lafrenz DE,Feldbush TL

更新日期：1987-08-01 00:00:00

abstract：:Applying 2 M KBr, membranes of Ehu were solubilized. By C3-affinity chromatography an activity could be isolated that inhibited the immune adherence reaction and C3b-dependent rosette formation. Since this material did not agglutinate EAC14oxy23b we termed it monovalent C3b receptor (mC3bR). PAGE and SDS-PAGE and stai...

journal_title：Immunology letters

authors： Mussel HH,Ehlen T,Schmitt M,Kazatchkine MD,Neyses L,Dierich MP

更新日期：1982-01-01 00:00:00

abstract：:Dendritic cells (DCs) are professional antigen presenting cells, well equipped to initiate an immune response. For effective induction of an immune response, DC should migrate from the periphery to the lymph node to present the antigen to T lymphocytes. Currently, tumor-antigen loaded DCs are used in clinical vaccinat...

journal_title：Immunology letters

authors： Eggert AA,van der Voort R,Torensma R,Moulin V,Boerman OC,Oyen WJ,Punt CJ,Diepstra H,de Boer AJ,Figdor CG,Adema GJ

更新日期：2003-10-09 00:00:00

abstract：:The regulatory effect of Z-100 on the balance of Th1/Th2 cell responses in BALB/c mice bearing Meth-A fibrosarcoma was investigated. In tumor bearing mice, Th1 cytokine production (IL-2, IFN-gamma) are suppressed and Th2 cytokine production (IL-4, IL-10) are increased, as compared with those of normal mice. The admini...

journal_title：Immunology letters

authors： Oka H,Emori Y,Ohya O,Kobayashi N,Sasaki H,Tanaka Y,Hayashi Y,Nomoto K

更新日期：1999-11-01 00:00:00

abstract：:Colonization with Streptococcus pneumoniae (S. pneumoniae) is associated with an increased risk for recurrent wheeze and asthma. Killed S. pneumoniae showed some potential as an effective immunomodulatory therapy in a murine model of asthma. Murine studies demonstrated protection against allergic asthma by symbiotic b...

journal_title：Immunology letters

authors： Hartmann C,Behrendt AK,Henken S,Wölbeling F,Maus UA,Hansen G

更新日期：2015-03-01 00:00:00

abstract：:The aim of this work was to raise allotype specific monoclonal antibodies to human CD45, with the long-term objective of producing a reagent which could be used to prolong graft survival in renal transplantation through removal of passenger leukocytes from the graft. At present there are no anti-CD45 monoclonal antibo...

journal_title：Immunology letters

authors： Dean GS,Aspinall R

更新日期：1999-06-01 00:00:00

abstract：:In rheumatoid arthritis, the synovium exhibits fibroblast hyperplasia and dynamic infiltration of activated T cells. Interaction between rheumatoid arthritis synovial fibroblasts (RASF) and T cell subsets such as Th17 cells can stimulate RASF to express IL-6, IL-8, CCL20, and other proinflammatory mediators of joint d...

journal_title：Immunology letters

authors： Friday SC,Fox DA

更新日期：2016-06-01 00:00:00

abstract：:It has been previously shown that normal human peripheral blood mononuclear cells produce a soluble factor(s) that causes selective inhibition of collagen production by cultured human diploid fibroblasts, and that stimulation of the mononuclear cells by appropriate mitogens greatly enhances its production. Because of ...

journal_title：Immunology letters

authors： Jimenez SA,Rosenbloom J

更新日期：1985-01-01 00:00:00

abstract：:To monitor genetically-controlled cytokine-producing ability in mice in vitro, we developed a high-density cell culture system, which is preferable for inducing CD4+ T cell-dependent self-priming responses without any antigenic stimulation. When BALB/c spleen cells were cultured at high density (over 1.0 x 10(7) cells...

journal_title：Immunology letters

authors： Sato M,Iwakabe K,Ohta A,Sekimoto M,Kimura S,Nishimura T

更新日期：1999-12-01 00:00:00

abstract：:Galectin-1 (Gal-1) has been implicated in tumor progression partly via the induction of T-cell apoptosis. However the mechanism of Gal-1 induced T-cell death was mostly studied using recombinant, soluble Gal-1 producing controversial results. To explore the true mechanism of Gal-1 and hence tumor cell-induced T-cell d...

journal_title：Immunology letters

authors： Kovács-Sólyom F,Blaskó A,Fajka-Boja R,Katona RL,Végh L,Novák J,Szebeni GJ,Krenács L,Uher F,Tubak V,Kiss R,Monostori E

更新日期：2010-01-04 00:00:00

abstract：:Drosophila has recently become a powerful model organism for studies of innate immunity. The cellular elements of innate immunity in Drosophila, the hemocytes, have been characterized by morphological criteria, molecular markers, and cell-type-specific immunological markers. Here we suggest that an MiET1 GFP-reporter ...

journal_title：Immunology letters

authors： Honti V,Kurucz E,Csordás G,Laurinyecz B,Márkus R,Andó I

更新日期：2009-09-22 00:00:00

abstract：:We describe the quantification of the absolute amounts of HLA class II mRNA and class II transactivator (CIITA) mRNA by competitive reverse transcription polymerase chain reaction in cultured synovial fibroblast-like cells (SFC) of patients with rheumatoid arthritis. High basal levels of transcription of class II mRNA...

journal_title：Immunology letters

authors： Navarrete Santos A,Riemann D,Thiele K,Kehlen A,Navarrete Santos A,Langner J

更新日期：1997-06-01 00:00:00