Abstract:
:The surface phenotypes of lymphoid cells in the developing embryonic thymus were characterized by using monoclonal antibodies. FT-2 antigen thus defined was predominantly expressed on thymocytes in the earlier embryonic stages in all the inbred mouse strains tested. The immunofluorescence and immunoperoxidase tests indicated that, like FT-1 antigen, the proportion of FT-2+ fetal thymocytes rapidly decreased with increase in gestation time, and these cells disappeared by day 19 of gestation. The treatment of fetal thymocytes with anti-FT-1 plus complement eliminated not only FT-1+, but also FT-2+ cells, whereas the treatment with anti-FT-2 failed to eliminate approximately 40% of FT-1+ cells, suggesting that embryonic thymocytes can be provisionally divided into at least three subpopulations, FT-1+2+, FT-1+2- and FT-1-2-.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Takashi T,Kasai M,Tanaka N,Takahashi T,Tokunaga Tdoi
10.1016/0165-2478(85)90004-5subject
Has Abstractpub_date
1985-01-01 00:00:00pages
259-62issue
5eissn
0165-2478issn
1879-0542pii
0165-2478(85)90004-5journal_volume
9pub_type
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