Models and methods for analysis of lymphocyte repertoire generation, development, selection and evolution.

abstract：:Recent advances in next-generation sequencing have enabled rapid and efficient evaluation of the mutational landscape of cancers. As a result, many cancer-specific neoantigens, which can generate antitumor cytotoxic T-cells inside tumors, have been identified. Previously, we reported a metastatic melanoma case with hi...

journal_title：Immunology letters

authors： Nonomura C,Otsuka M,Kondou R,Iizuka A,Miyata H,Ashizawa T,Sakura N,Yoshikawa S,Kiyohara Y,Ohshima K,Urakami K,Nagashima T,Ohnami S,Kusuhara M,Mitsuya K,Hayashi N,Nakasu Y,Mochizuki T,Yamaguchi K,Akiyama Y

更新日期：2019-04-01 00:00:00

abstract：:Malaria vaccine development has traditionally concentrated on careful molecular, biochemical, and immunological characterisation of candidate antigens. In contrast, evidence of the importance of identified antigens in immunity to human infection and disease has generally been limited to statistically significant co-va...

journal_title：Immunology letters

authors： Staalsoe T,Jensen AT,Theander TG,Hviid L

更新日期：2002-11-01 00:00:00

abstract：:We have utilized a limiting dilution assay, involving a minimum of in vitro culture, to determine the frequencies of CD4+ T cells which have the capacity to secrete IL-2 (Th1), IL-4 (Th2) or IL-2 and IL-4 (Th0). CD4+ lymph node cells obtained from unimmunized mice were found to contain 40% Th1, 34% Th2, and 26% Th0 ce...

journal_title：Immunology letters

authors： Torbett BE,Laxer JA,Glasebrook AL

更新日期：1990-01-01 00:00:00

abstract：:Many details in the expression pattern of Epstein-Barr virus (EBV)-encoded proteins, their role in blast and growth transformation in infected B lymphocytes are known, but 'black holes' still exist. The two main types of virus-B lymphocyte interactions are denoted as Type I and Type III. These are characterized by the...

journal_title：Immunology letters

authors： Klein E,Teramoto N,Gogolák P,Nagy N,Björkholm M

更新日期：1999-05-03 00:00:00

abstract：:Receptor-binding by the B-subunit of Escherichia coli heat-labile enterotoxin (EtxB) induces apoptosis of peripheral CD8(+), but not CD4(+) T-cells. Given that peripheral CD8(+) and CD4(+) T cells arise from a common developmental pathway in the thymus, we investigated the effects of EtxB on different thymocyte popula...

journal_title：Immunology letters

authors： Salmond RJ,Williams R,Hirst TR,Williams NA

更新日期：2003-07-03 00:00:00

abstract：:We have studied the autocrine regulation of essential expression of the intercellular adhesion molecule-1 (ICAM-1) on 8 transitional cell carcinoma (TCC) cell lines (histopathological grades 1-3). The constitutive expression of ICAM-1 was regulated by soluble factors in an autocrine fashion. These factors were produce...

journal_title：Immunology letters

authors： Alexandroff AB,Jackson AM,Esuvaranathan K,Prescott S,James K

更新日期：1994-05-01 00:00:00

abstract：:ITIM-bearing receptors, a family which only recently has been recognized, play a key role in the regulation of the ITAM-induced activation of immune competent cells. The mechanism of ITM-mediated regulation in various cells was recently clarified. The present review focuses on ITIM bearing membrane proteins that negat...

journal_title：Immunology letters

authors： Gergely J,Pecht I,Sármay G

更新日期：1999-05-03 00:00:00

abstract：:Interleukin-35 (IL-35) is a novel anti-inflammatory cytokine and has been shown to play an important role in maintaining immune homeostasis. However, the effect of IL-35 on human asthma remains unclear. The present study is to investigate the expression and significance of IL-35 in childhood asthma. Forty-one asthmati...

journal_title：Immunology letters

authors： Ma Y,Liu X,Wei Z,Wang X,Xu D,Dai S,Li Y,Gao M,Ji C,Guo C,Zhang L,Wang X

更新日期：2014-11-01 00:00:00

abstract：:To study the interactions between Chlamydia trachomatis (CT) and human immunodeficiency virus (HIV) infections, we examined CT serologies in sequential serum samples of male homosexuals (MHS), followed over a mean period of 4 years. Of the MHS studied, 77 were HIV(-), 18 were HIV(+) and 10 patients seroconverted durin...

journal_title：Immunology letters

authors： Schattner A,Hanuka N,Sarov B,Bentwich Z

更新日期：1994-04-01 00:00:00

abstract：:Cigarette smoke contains nicotine, an immunomodulatory component that is thought to affect immune surveillance and increase the progression of diseases. Dendritic cells (DCs) constitute a family of antigen-presenting (APCs) with inherent abilities to sense and translate environmental cues and to shape host immunity. W...

journal_title：Immunology letters

authors： Nouri-Shirazi M,Tinajero R,Guinet E

更新日期：2007-04-15 00:00:00

abstract：:The effect of melphalan (L-PAM; L-phenylalanine mustard) administration on natural killer (NK) and natural cytotoxic (NC) activities of spleen cells from normal noninoculated BALB/c mice and mice bearing large MOPC-315 plasmacytoma tumors was investigated. Injection of L-PAM (7.5 or 15.0 mg/kg) had no effect on NK and...

journal_title：Immunology letters

authors： Nahas F,Ophir R,Ben-Efraim S

更新日期：1985-01-01 00:00:00

abstract：:RasGRP1 links TCR signaling to Ras in T cells, while both RasGRP1 and RasGRP3 link BCR signaling to Ras in B cells. T cells deficient in RasGRP1 have defective proliferative responses as do B cells deficient in both RasGRP1 and RasGRP3, confirming the importance of Ras activation in lymphocyte proliferation. While age...

journal_title：Immunology letters

authors： Coughlin JJ,Stang SL,Dower NA,Stone JC

更新日期：2006-05-15 00:00:00

abstract：:Cloned human T-cell lines were produced by limiting dilution of lymphocytes alloactivated in mixed leukocyte cultures, followed by expansion of clonal progeny with interleukin 2. Selected clones were analyzed for cell-mediated cytotoxicity (CTX) against a variety of targets susceptible or resistant to lytic attack by ...

journal_title：Immunology letters

authors： Pawelec G,Hadam M,Müller C,Wernet P

更新日期：1982-05-01 00:00:00

abstract：:The aim of this work was to raise allotype specific monoclonal antibodies to human CD45, with the long-term objective of producing a reagent which could be used to prolong graft survival in renal transplantation through removal of passenger leukocytes from the graft. At present there are no anti-CD45 monoclonal antibo...

journal_title：Immunology letters

authors： Dean GS,Aspinall R

更新日期：1999-06-01 00:00:00

abstract：:The T cell receptor of gamma delta is normally expressed on a small percentage of peripheral lymphocytes. Although the role of gamma delta T cells in the physiologic immune response is still unknown, there is accumulating evidence that gamma delta T cells may participate in the immune response to mycobacterial and oth...

journal_title：Immunology letters

authors： Ho M,Webster HK,Tongtawe P,Pattanapanyasat K,Weidanz WP

更新日期：1990-08-01 00:00:00

abstract：:Partially purified IgE receptor(s) of rat basophilic leukemia cells (RBL) designated R and H and having apparent molecular weight of 45,000 and 55,000 daltons, respectively, were subjected to proteolysis with papain. Polyacrylamide gel electrophoresis of the digests in the presence of sodium dodecyl sulfate revealed a...

journal_title：Immunology letters

authors： Roth PA,Froese A

更新日期：1982-03-01 00:00:00

abstract：BACKGROUND:CD3 and CD19 are the characteristic surface markers of mature T lymphocytes and B lymphocytes of human respectively. A special subset of immune cells that characteristically expressed the surface markers CD19+ of B lymphocytes and CD3+ of T lymphocytes simultaneously (CD19+CD3+ cells, hereinafter referred to...

journal_title：Immunology letters

authors： Liu Y,Ye S,Guo X,Li W,Xia Y,Wen X,Yu J,Jia Y,Liu X,Guo Y,Zhao Y

更新日期：2020-04-01 00:00:00

abstract：:Administration of opioids that bind to the classical mu opioid receptor has been shown to lead to unintended alterations in immune function. Traditionally, altered immune function has been investigated with circulating immune cells. Effects of mu agonists on intestinal epithelial immune function have not been describe...

journal_title：Immunology letters

authors： Neudeck BL,Loeb JM

更新日期：2002-12-03 00:00:00

abstract：:The monoclonal antibody (mAb) UN2 was generated upon immunization of a Balb/c mouse with human thymocytes. mAb UN2 recognized an antigen expressed by a subpopulation of human thymocytes and peripheral blood lymphocytes. In thymus, mAb UN2 recognized cortical cells; its expression was higher on CD3bright than on CD3dim...

journal_title：Immunology letters

authors： Tassone P,Bonelli P,Tuccillo F,Turco MC,De Rosa G,Morrone G,Cecco L,Cerra M,Petrella A,Nigro M

更新日期：1994-09-01 00:00:00

abstract：:Atopic dermatitis (AD) and allergic contact dermatitis (ACD) are common skin inflammatory conditions. B and T cells are strongly implicated in allergic contact hypersensitivity (CHS) conditions. Activation of IgD B-cell receptor (BCR) by anti-IgD stimulation depletes mature B cells and modulates T-helper cell type 1/2...

journal_title：Immunology letters

authors： Nguyen TG

更新日期：2018-11-01 00:00:00

abstract：:A variety of straightforward biochemical techniques have been applied to the analysis of HLA molecules. These techniques centre largely on two components: monoclonal antibodies (mAbs) and gel analysis systems. Although only the basic applications are discussed here, the techniques have broad applications. Monoclonal-g...

journal_title：Immunology letters

authors： Lanchbury JS

更新日期：1991-07-01 00:00:00

abstract：:Transplantation immunologists have long been intrigued by the natural allograft that results from normal mammalian pregnancy. Its general success contrasts with the rejection problems associated with most artifactual organ transplantation and raises intriguing questions concerning the nature of the mechanisms involved...

journal_title：Immunology letters

authors： Wegmann TG

更新日期：1988-04-01 00:00:00

abstract：:The effect of ageing on thymocyte progenitors in the bone marrow was studied in an in vitro experimental model that permits T lymphocyte development. The model is based on co-culture of BM cells from young and old mice with lymphoid depleted fetal thymus explants. We applied different strategies of thymic colonization...

journal_title：Immunology letters

authors： Globerson A

更新日期：1994-06-01 00:00:00

abstract：:Murine peritoneal macrophages were isolated by adherence and their listericidal activity assessed in the presence or absence of selected cytokines. Untreated macrophages were not highly listericidal, showing moderate killing in the first 2 h after infection, and allowed progressive microbial growth thereafter (up to 9...

journal_title：Immunology letters

authors： Denis M,Gregg EO

更新日期：1991-03-01 00:00:00

abstract：:We have analysed the relative T cell receptor (TCR) BV gene usage in T cells from hearts and spleens of CBA/HJ mice chronically infected with the Tulahuén strain of Trypanosoma cruzi. During chronic infection, CBA/HJ mice recruit T cells at the major site of inflammation (i.e. the heart), with over-representation of c...

journal_title：Immunology letters

authors： Sunnemark D,Andersson R,Harris RA,Jeddi-Tehrani M,Orn A

更新日期：1998-02-01 00:00:00

abstract：:A majority of human immunodeficiency virus type 1 (HIV-1) infected individuals display a rapid loss of CD4+ lymphocytes with fast progression towards overt acquired immunodeficiency syndrome (AIDS). However, a small proportion of individuals infected by HIV-1 remain immunologically intact for many years. In order to i...

journal_title：Immunology letters

authors： Scarlatti G,Leitner T,Hodara V,Jansson M,Karlsson A,Wahlberg J,Rossi P,Uhlén M,Fenyö EM,Albert J

更新日期：1996-06-01 00:00:00

abstract：:A monoclonal human rheumatoid factor (RF-AN) reactive with human Fc gamma is shown to recognise a discontinuous epitope dependent on the presence of histidine (His) at residue 435. RF-AN is not reactive with IgG1 paraproteins having C gamma 2 or C gamma 3 domain deletions or IgG3m (5) or Ig3m (21) proteins having argi...

journal_title：Immunology letters

authors： Jefferis R,Nik Jaafar MI,Steinitz M

更新日期：1984-01-01 00:00:00

abstract：:A broad array of biological responses including cell polarization, movement, immune and inflammatory responses, as well as prevention of HIV-1 infection, are triggered by the chemokines, a family of secreted and structurally related chemoattractant proteins that bind to class A-specific seven-transmembrane receptors l...

journal_title：Immunology letters

authors： Muñoz LM,Holgado BL,Martínez-A C,Rodríguez-Frade JM,Mellado M

更新日期：2012-07-30 00:00:00

abstract：:Work done in our laboratories, using a murine model, indicates that suppression of host immune responses might be due to secretion of soluble factors by tumor cells. The H238 cells (BALB/c embryonic fibroblasts transformed by UV-inactivated herpes simplex virus Type 2) exhibit progressive tumor growth with subsequent ...

journal_title：Immunology letters

authors： Das MR,Gridley DS,Kettering JD

更新日期：1991-09-01 00:00:00

abstract：:Interleukin-18 (IL-18) is a novel pro-inflammatory cytokine which has been implicated to play a pathogenic role in rheumatoid arthritis (RA). Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis in rheumatoid synoviocytes. In present study, we examined the effect of IL-18 on VEGF productio...

journal_title：Immunology letters

authors： Cho ML,Jung YO,Moon YM,Min SY,Yoon CH,Lee SH,Park SH,Cho CS,Jue DM,Kim HY

更新日期：2006-03-15 00:00:00