Abstract：
:RasGRP1 links TCR signaling to Ras in T cells, while both RasGRP1 and RasGRP3 link BCR signaling to Ras in B cells. T cells deficient in RasGRP1 have defective proliferative responses as do B cells deficient in both RasGRP1 and RasGRP3, confirming the importance of Ras activation in lymphocyte proliferation. While aged Rasgrp1-/- mice develop late-onset autoimmunity characterized by splenomegaly and the presence of anti-nuclear antibodies (ANA), the additional loss of RasGRP3 expression inhibits this phenotype. We show here that the autoimmunity in Rasgrp1-/- mice is T cell dependent. Compared to wildtype, Rasgrp1-/- T cells induce greater in vitro B cell proliferation that is due, at least in part, to increased production of interleukin-4 (IL-4). Rasgrp1 Rasgrp3 double mutant B cells are less responsive to this T cell stimulation. The reduced double mutant B cell proliferative response was paralleled by decreased induction of cyclin D2 upon stimulation with IL-4 and anti-IgM. Taken together these results suggest that double mutant mice fail to generate autoimmunity due to their decreased B cell cyclin D2 accumulation, and thus proliferation, in response to the elevated levels of IL-4 produced by mutant T cells.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Coughlin JJ,Stang SL,Dower NA,Stone JCdoi
10.1016/j.imlet.2006.01.005subject
Has Abstractpub_date
2006-05-15 00:00:00pages
77-82issue
1eissn
0165-2478issn
1879-0542pii
S0165-2478(06)00055-1journal_volume
105pub_type
杂志文章abstract：:In the present investigations we aimed to study the effect of Shigella sonnei lipopolysaccharide (LPS) on delayed type hypersensitivity (DTH) to non-bacterial antigen in CBA mice. These experiments showed that intraperitoneal injection of phenol-water extracted LPS and avirulent S. sonnei did not affect the level of D...
journal_title：Immunology letters
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journal_title：Immunology letters
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journal_title：Immunology letters
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journal_title：Immunology letters
pub_type： 杂志文章
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journal_title：Immunology letters
pub_type： 杂志文章,评审
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journal_title：Immunology letters
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journal_title：Immunology letters
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journal_title：Immunology letters
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journal_title：Immunology letters
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.10.012
更新日期：2005-04-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.12.003
更新日期：2005-05-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(95)00043-5
更新日期：1995-05-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
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更新日期：1990-08-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.05.006
更新日期：2009-06-30 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2013.01.002
更新日期：2013-02-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(89)90126-0
更新日期：1989-12-01 00:00:00
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journal_title：Immunology letters
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更新日期：2014-11-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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journal_title：Immunology letters
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journal_title：Immunology letters
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journal_title：Immunology letters
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journal_title：Immunology letters
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journal_title：Immunology letters
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：1984-01-01 00:00:00
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journal_title：Immunology letters
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journal_title：Immunology letters
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更新日期：2018-09-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.02.002
更新日期：2017-03-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90122-7
更新日期：1986-08-01 00:00:00
