Regulation of IL-18 expression by CRH in mouse microglial cells.

abstract：:ITIM-bearing receptors, a family which only recently has been recognized, play a key role in the regulation of the ITAM-induced activation of immune competent cells. The mechanism of ITM-mediated regulation in various cells was recently clarified. The present review focuses on ITIM bearing membrane proteins that negat...

journal_title：Immunology letters

authors： Gergely J,Pecht I,Sármay G

更新日期：1999-05-03 00:00:00

abstract：:Disease-modifying osteoarthritis (OA) therapy is not yet available. Several adjuvant therapies have demonstrated promising results in the treatment of OA. The present study aimed to investigate the therapeutic effects and underlying mechanisms of a combination of Lactobacillus acidophilus, vitamin B, and curcumin in t...

journal_title：Immunology letters

authors： Jhun J,Min HK,Na HS,Kwon JY,Ryu J,Cho KH,Choi J,Jung K,Lee SY,Kim SJ,Yang CW,Park SH,Cho ML

更新日期：2020-12-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is caused by chronic inflammation of the gastrointestinal tract. The pathogenesis of IBD remains unclear. The inflammation is associated with activation of T helper (Th) lymphocytes and chronic production of inflammatory cytokines. Ro60 suppresses the expression of tumor necrosis facto...

journal_title：Immunology letters

authors： Kim SY,Park MJ,Kwon JE,Choi SY,Seo HB,Jung KA,Choi JW,Baek JA,Lee HH,Lee BI,Park SH,Cho ML

更新日期：2018-09-01 00:00:00

abstract：:Pretreatment of murine bone marrow-derived macrophages with wheat germ agglutinin (WGA) and concanavalin A (Con A) markedly enhanced the uptake of Staphylococcus aureus H and Escherichia coli 08, respectively. Pretreatment of the respective bacteria with these lectins also greatly increased their uptake by the macroph...

journal_title：Immunology letters

authors： Gallily R,Stain I,Zaady O

更新日期：1986-09-01 00:00:00

abstract：:The intestinal immune system maintains a delicate balance between immunogenicity against invading pathogens and tolerance of the commensal microbiota and food antigens. Dendritic cells (DC) generate primary T-cell responses, and determine whether these responses are immunogenic or tolerogenic. The regulatory role of D...

journal_title：Immunology letters

authors： Mann ER,Landy JD,Bernardo D,Peake ST,Hart AL,Al-Hassi HO,Knight SC

更新日期：2013-02-01 00:00:00

abstract：:Treatment of purified human C5 with hydrogen peroxide leads to a reduction of functional activity in the classical immune haemolysis assay. The effect of H2O2 is enhanced by traces of iron-EDTA, and becomes even stronger when ascorbic acid is present in addition. The enhancement by iron and protective effects of vario...

journal_title：Immunology letters

authors： von Zabern WV,Hesse D,Nolte R,Haller Y

更新日期：1987-02-01 00:00:00

abstract：:In studying terminal lytic events of sensitized erythrocytes which have reacted with all 9 components of complement, we agree in general with the conclusions of Boyle and Borsos [1] that the cellular intermediate passes through the stages E*bound, E*inserted, and E*doomed. However, we differ with these workers on the ...

journal_title：Immunology letters

authors： Wirtz GH,Westfall SS

更新日期：1981-04-01 00:00:00

abstract：:Serum obtained from mice infected with Trypanosoma cruzi have antibodies able to induce immune lysis in presence of complement. Gel filtration in Sephadex G-200 and affinity chromatography with rabbit anti-mouse IgG and protein A-Sepharose showed that the antibodies responsible for the immune serum lytic activity are ...

journal_title：Immunology letters

authors： Stefani MM,Takehara HA,Mota I

更新日期：1983-01-01 00:00:00

abstract：:HLA-specific antibodies generated by allo-immunization are supposed to be involved in the control of HIV infections by both the neutralizing capacity of HLA-specific antibodies (Abs) and HLA-specific Ab-dependent complement-mediated lysis (CML). We further characterized CML of HIV primary isolates induced by HLA-speci...

journal_title：Immunology letters

authors： Hildgartner A,Wilflingseder D,Gassner C,Dierich MP,Stoiber H,Bánki Z

更新日期：2009-09-22 00:00:00

abstract：:Toll-like receptors (TLR) are critical in the activation of macrophages by bacterial products. It has been shown that TLR2 and TLR4 mediate lipopolysaccharide (LPS) and lipoproteins signal transduction, respectively. Regulation of TLR2 and TLR4 expression by LPS was considered to be one of the mechanisms to control th...

journal_title：Immunology letters

authors： An H,Xu H,Yu Y,Zhang M,Qi R,Yan X,Liu S,Wang W,Guo Z,Qin Z,Cao X

更新日期：2002-05-01 00:00:00

abstract：:We established two clones of monoclonal hybridoma, from a non-immunized NZB mouse, which produce IgM class hemagglutinating autoantibodies reactive with the exposed murine erythrocyte autoantigens. Absorption studies revealed that one monoclonal antibody exhibits cross-reactivity to chick erythrocytes and mouse liver,...

journal_title：Immunology letters

authors： Ozaki S,Nagasawa R,Sato H,Shirai T

更新日期：1984-01-01 00:00:00

abstract：AIM:To develop new approach for tumor immunotherapy with VEGFR2-based DNA vaccine. METHODS:VEGFR2 derived from different species were prepared by RT-PCR and subjected to recombinant constructs. The chimeric gene of VEGFR2 was prepared by integrating different epitopes in different species. By transfecting into cells, ...

journal_title：Immunology letters

authors： Yan J,Jia R,Song H,Liu Y,Zhang L,Zhang W,Wang Y,Zhu Y,Yu J

更新日期：2009-09-22 00:00:00

abstract：:Protective immunity against Salmonella infection is known to require CD4 Th1 cells and B cells, but the role of MHC class-I-restricted CD8 T cells is less clear. Previous studies have suggested that CD8 T cells participate in secondary, but not primary, bacterial clearance. However, these studies have used experimenta...

journal_title：Immunology letters

authors： Lee SJ,Dunmire S,McSorley SJ

更新日期：2012-12-17 00:00:00

abstract：:The effect of B cell depletion on the induction and severity of murine experimental autoimmune thyroiditis was investigated. Thirteen CBA mice were given repeated intraperitoneal doses of 700 micrograms purified rabbit anti-mouse Ig antibody from 24 hours to 8 weeks after birth. Controls were given normal rabbit IgG (...

journal_title：Immunology letters

authors： Rayfield LS,Smith TA,Andrews SJ,Bergmeier LA

更新日期：1989-01-15 00:00:00

abstract：:The earliest T-cell precursor population in the adult mouse thymus (low CD4 precursors) may be divided into 85% of cells expressing surface Mel-14 (LECAM-1, the lymphocyte homing receptor) and 15% of cells which are Mel-14. To date, this is the only surface marker for which we have found this population to be heteroge...

journal_title：Immunology letters

authors： Wu L,D'Amico A

更新日期：1994-05-01 00:00:00

abstract：:Multiple antigen peptides (MAP), consisting of a number of peptide copies synthesized on a branching lysyl core, offer a novel approach for rendering small peptides immunoreactive in solid-phase immunoassays. An octameric MAP, carrying 6 repeats of the sequence -N-A-A-G-, tandem repeated in the immunodominant region o...

journal_title：Immunology letters

authors： Habluetzel A,Pessi A,Bianchi E,Rotigliano G,Esposito F

更新日期：1991-09-01 00:00:00

abstract：:To monitor genetically-controlled cytokine-producing ability in mice in vitro, we developed a high-density cell culture system, which is preferable for inducing CD4+ T cell-dependent self-priming responses without any antigenic stimulation. When BALB/c spleen cells were cultured at high density (over 1.0 x 10(7) cells...

journal_title：Immunology letters

authors： Sato M,Iwakabe K,Ohta A,Sekimoto M,Kimura S,Nishimura T

更新日期：1999-12-01 00:00:00

abstract：:It has been previously shown that normal human peripheral blood mononuclear cells produce a soluble factor(s) that causes selective inhibition of collagen production by cultured human diploid fibroblasts, and that stimulation of the mononuclear cells by appropriate mitogens greatly enhances its production. Because of ...

journal_title：Immunology letters

authors： Jimenez SA,Rosenbloom J

更新日期：1985-01-01 00:00:00

abstract：:Interleukin 2 (IL 2) is a lymphocyte growth factor capable of inducing the rapid growth of antigen- or mitogen-stimulated T cells. To understand the molecular mechanisms of IL 2 action, we studied the synthesis of cellular polypeptides induced by IL 2. For a homogeneous cell population responsive to IL 2, we used a mu...

journal_title：Immunology letters

authors： Yoshie O,Wada J,Ishida N

更新日期：1985-01-01 00:00:00

abstract：:Stress stimuli affect the immune system responses that occur at mucosal membranes, particularly IgA secretion. It has been suggested that acute stress increases the levels of IgA and that sympathetic innervation plays an important role in this process. We herein explore in a murine model how acute stress affects the T...

journal_title：Immunology letters

authors： Gutiérrez-Meza JM,Jarillo-Luna RA,Rivera-Aguilar V,Miliar-García A,Campos-Rodríguez R

更新日期：2017-08-01 00:00:00

abstract：:Colonization with Streptococcus pneumoniae (S. pneumoniae) is associated with an increased risk for recurrent wheeze and asthma. Killed S. pneumoniae showed some potential as an effective immunomodulatory therapy in a murine model of asthma. Murine studies demonstrated protection against allergic asthma by symbiotic b...

journal_title：Immunology letters

authors： Hartmann C,Behrendt AK,Henken S,Wölbeling F,Maus UA,Hansen G

更新日期：2015-03-01 00:00:00

abstract：:Coelomic fluid from the earthworm Lumbricus terrestris is known to contain immunoactive cells and molecules involved in immune defense. To assess the ability of such molecules to form precipitating complexes with anti-human immunoglobulins, radial immunodiffusion experiments were conducted. Anti-human IgG, anti-human ...

journal_title：Immunology letters

authors： Eyambe GS

更新日期：1993-02-01 00:00:00

abstract：:Donor-specific blood transfusion (DST) improves allograft survival, although the exact mechanism(s) is not completely understood. The purpose of this study was to determine the role of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) in DST-protective effects, using a rat cardiac transplantation model. Lewis rats (RT...

journal_title：Immunology letters

authors： Inuzuka S,Koga S,Nishikido M,Miyata Y,Kanda S,Shimokawa I,Tanaka M,Saito Y,Kanetake H

更新日期：2002-09-02 00:00:00

abstract：:The present study was designed to investigate whether human equivalents of murine T helper cell subsets can be demonstrated by propagation of peripheral blood lymphocytes (PBL) with either recombinant human (rh) interleukin (IL) 2 or rhIL4 in the presence of neutralising antibodies. Cells of both cultures, termed T-IL...

journal_title：Immunology letters

authors： Kalthoff FS,Rossiter H,Liehl E

更新日期：1991-02-01 00:00:00

abstract：:This report describes an immunoradiometric assay for Plasmodium falciparum in infected blood, based on a cross-reacting monoclonal antibody (mAb) raised against P. berghei. In this assay, binding of the mAb to intact P. berghei parasites coated on microtiter plates is inhibited by solubilized P. falciparum infected re...

journal_title：Immunology letters

authors： Pass A,Avidor B,Golenser J,Laskov R,Sulitzeanu D

更新日期：1985-01-01 00:00:00

abstract：:It has been shown that engraftment of human peripheral blood lymphocytes (PBL) from Epstein-Barr virus (EBV) seropositive donors in C.B-17/SCID mice is associated with a high incidence of human B cell tumors. More recently, we described a new approach enabling engraftment of human PBL in normal strains of mice or rats...

journal_title：Immunology letters

authors： Marcus H,Burakova T,Shezen E,David M,Canaan A,Lubin I,Reisner Y

更新日期：1996-03-01 00:00:00

abstract：:A survey of the appearance of natural antibodies in C57BL/6 mice, measured by a complement-dependent cytotoxicity test against syngeneic radiation leukemia virus-induced lymphoma, was performed. Activity could be detected in sera from 5- to 14-month-old animals. This activity could be attributed mainly to IgM antibodi...

journal_title：Immunology letters

authors： Rubio N

更新日期：1981-10-01 00:00:00

abstract：:An effective HIV vaccine will likely need to induce potent and broad-based immunity, including CD8+ T cell responses. Hence, a quantitative assay to measure such responses in animal models will be important in the evaluation of candidate HIV vaccines. We show here that a single immunization with HIV DNA vaccines, foll...

journal_title：Immunology letters

authors： Otten GR,Chen M,Doe B,zur Megede J,Barnett S,Ulmer J

更新日期：2003-01-22 00:00:00

abstract：:A considerable body of evidence from various laboratories indicates that specific T cell responses generated during infection with Leishmania parasites play an important role both in the resolution and progression of cutaneous leishmaniasis. Recent data, summarized in this article, indicate that resolution of lesions ...

journal_title：Immunology letters

authors： Müller I,Pedrazzini T,Louis JA

更新日期：1988-11-01 00:00:00

abstract：:The aim of the present letter is to propose a rational nomenclature for the d-mannose-binding lectin from seeds of Artocarpus integrifolia. It is justified by the existing confusion in the literature concerning the trivial names used until now to designate the lectin and by the increasing interest in its biomedical ap...

journal_title：Immunology letters

authors： Pereira-da-Silva G,Roque-Barreira MC,Van Damme EJ

更新日期：2008-08-15 00:00:00