Abstract:
:The majority of peripheral blood mononuclear cells (PBMC) from acute-phase infectious mononucleosis (IM) patients express high levels of T10 (CD38) and HLA-DR surface antigens, which are markers characteristic of activated T cells. However, Tac antigen (p55) expression on these cells was not detectable by flow cytometric immunofluorescence, and only a low level of specific interleukin-2 (IL-2) binding was found by Scatchard analysis. These results suggest that IL-2 receptors (IL-2R) are lost or down-regulated on activated T cells in acute IM. Since a large proportion of T cells die during the first 24 h of in vitro culture in the absence of exogenous IL-2, the data implicate a physiological role for the observed low levels of IL-2R on T cells.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Schmidt C,Burman K,Moss DJ,Ryan J,Burrows SR,Misko ISdoi
10.1016/0165-2478(89)90126-0subject
Has Abstractpub_date
1989-12-01 00:00:00pages
139-42issue
2eissn
0165-2478issn
1879-0542pii
0165-2478(89)90126-0journal_volume
23pub_type
杂志文章abstract::H-2-linked gene(s) have been found to play a role in the quantitative regulation of response to human gamma-globulin (HGG) in mice selected for high or low antibody responsiveness to sheep erythrocytes. Unexpectedly, in a random genetically heterogeneous population of F2 interline hybrids, the gene(s) linked to the H-...
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journal_title:Immunology letters
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journal_title:Immunology letters
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journal_title:Immunology letters
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journal_title:Immunology letters
pub_type: 杂志文章
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abstract::When IL-4 mRNA was distinguished from mRNA encoding its antagonist, the splice variant IL-4delta2, it was found to correlate directly with expression of TLR2 in fresh peripheral blood mononuclear cells (PBMCs) from normal donors (p=0.0013). Similarly IL-4 mRNA was high when TLR2 mRNA was abundant compared to levels of...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2006.06.001
更新日期:2006-08-15 00:00:00
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更新日期:1996-12-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(00)00275-3
更新日期:2000-12-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.03.006
更新日期:2004-05-15 00:00:00
abstract::A TNF-like factor was purified from lipopolysaccharide (LPS) induced New Zealand white rabbit serum. The TNF-like factor was purified by DEAE-Sephacel, Sephacryl S-200, Mono-Q, CM-affi gel Blue, Superose 12 H/R preparative columns to the specific activity of 4 x 10(6) U/mg protein. The purified protein was 45 kDa in i...
journal_title:Immunology letters
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更新日期:1998-02-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90084-n
更新日期:1991-09-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
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更新日期:2010-10-30 00:00:00
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更新日期:1995-12-01 00:00:00
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journal_title:Immunology letters
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更新日期:1994-02-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1988-09-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:2005-06-15 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90125-t
更新日期:1991-04-01 00:00:00
abstract::To explore the genetic association of single nucleotide polymorphisms (SNPs) in the coding region of the NOTCH4, exon 3 C+1297T and exon 5 A+3063G, in a case-control analysis of 58 rheumatoid arthritis (RA) and 98 alopecia areata (AA) and 100 ethnically matched healthy subjects. NOTCH4 polymorphisms were genotyped by ...
journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:2013-02-01 00:00:00
abstract::The biological activity of six synthetic peptides of the 124-144 region of the human interferon alpha-2 (IFN alpha-2) molecule was studied. Peptides were examined for their ability to inhibit mitogen induced proliferation of human blood cells in vitro. Only the peptide corresponding to the amino acid sequence 124-138 ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90004-8
更新日期:1992-01-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2012.08.002
更新日期:2012-11-01 00:00:00
abstract::Type I Diabetes mellitus (DM1) is the effect of T cell dependent autoimmune destruction of insulin producing beta cells in the pancreas islet. T cells are activated in response to islet dominant autoantigens, the result being the development of DM1. Insulin is one of the islet autoantigens responsible for activation o...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(00)00309-6
更新日期:2001-01-15 00:00:00
abstract::Idiopathic thrombocytopenic purpura (ITP) is an acquired autoimmune disorder. Both impaired platelet production and T cell-mediated effects play a role in ITP thrombocytopenia. A Th1 polarization of the immune response, up-regulation of Th17 cells and decreased number of Treg cells have been demonstrated in ITP patien...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.08.006
更新日期:2013-07-01 00:00:00