Abstract：
:Previously we reported that a mega-dose of Vitamin C enhanced the initial stage of delayed-type hypersensitivity reaction in Balb/c mice. In this study its effects were further evaluated as follows. Mice were administered Vitamin C intraperitoneally at 0.625 mg/day or at 5mg/day for variable days before, during, or after being sensitized with DNFB. T cells were isolated in each group and examined. When stimulated antigen-specifically or non-specifically in vitro, mice showed elevated thymidine uptake and a shift of cytokine secretion profiles toward Th1, i.e., elevated levels IL-2, TNF-alpha, and IFN-gamma, and lowered level of the Th2 cytokine IL-4, only when Vitamin C was administered during sensitization. T cells from those mice administered Vitamin C before sensitization or after challenge showed the same T cell properties as those from PBS-treated mice. Mice were also given 0.625 mg/day of Vitamin C during primary and/or secondary immunizations with KLH and secondary specific antibody titers in sera were measured. The total specific antibody titer was lowered in Vitamin C-treated animals whenever treatments were administered, and this was entirely attributed to decreased levels of IgG1 and IgE antibodies. Based on these results, we suggest that an exogenously administered mega-dose of Vitamin C shifts immunity in Balb/c mouse toward Th1 and that these affects occur only when Vitamin C is administered during T cell activation.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Noh K,Lim H,Moon SK,Kang JS,Lee WJ,Lee D,Hwang YIdoi
10.1016/j.imlet.2004.10.012subject
Has Abstractpub_date
2005-04-15 00:00:00pages
63-72issue
1eissn
0165-2478issn
1879-0542pii
S0165-2478(04)00288-3journal_volume
98pub_type
杂志文章abstract：:When human peripheral blood lymphocytes (PBL) are cultured with either concanavalin A (Con A)-treated or control autologous T lymphocytes, the mitogenic responses of the PBL co-cultured with Con A-treated cells are much lower. We have investigated the cell surface receptor changes during culture of T cells with and wi...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90031-2
更新日期：1984-01-01 00:00:00
abstract：:While cases of silicosis are often complicated by various autoimmune disorders, patients with asbestosis develop malignant tumors such as lung cancer and malignant mesothelioma. These differences may derive from different biological effects, particularly on immunological cells, of silica and asbestos. To find differen...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.11.005
更新日期：2005-04-15 00:00:00
abstract：BACKGROUND:Vitamin D (vitD) is involved in important regulatory functions of the innate and adaptive immune system. So, it has been hypothesized that vitD might influence the course of atopic dermatitis (AD). Also obesity may have impact on immune system. The aim of our study was to investigate vitamin D status and bod...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.11.004
更新日期：2017-01-01 00:00:00
abstract：:There has been significant progress in the field of heart transplantation over the last 45 years. Although the role of adaptive immunity in heart allograft rejection has been extensively studied for decades, there is increasing evidence that suggests that the innate immune system also contributes to the development of...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2017.11.014
更新日期：2018-02-01 00:00:00
abstract：:This paper describes a new murine monoclonal antibody, UN5, raised against human thymocytes. This antibody recognizes a molecule of approximately 45 kDa on thymocytes. Flow cytometric analysis reveals a high intensity of labeling with the majority of thymocytes, whereas only CD20+ cells from peripheral whole-blood sam...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90098-1
更新日期：1994-02-01 00:00:00
abstract：:Rheumatic fever (RF) and chronic rheumatic heart disease (RHD) are complications of oropharyngeal infection caused by Streptococcus pyogenes. Despite the importance of the complement system against infections and autoimmunity diseases, studies on the role of the lectin pathway in RF and RHD are scarce. Thus, our aim w...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2020.11.006
更新日期：2021-01-01 00:00:00
abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multifaceted hematopoietic cytokine and the culture of mouse bone marrow with GM-CSF produces a variety of myeloid cells including granulocytes, macrophages, and dendritic cells. In the present study, we cultured mouse splenocytes with GM-CSF and examined ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.03.003
更新日期：2016-05-01 00:00:00
abstract：:A majority of natural killer (NK) cells constitutively express intermediate affinity IL2 receptors made of beta gamma chains and respond by way of enhanced cytokine secretion. However, alterations in cytokine sensitivity of purified NK cells with respect to cytokine secretion during immunosenescence have not been exam...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(96)02519-9
更新日期：1996-04-01 00:00:00
abstract：:Drosophila has recently become a powerful model organism for studies of innate immunity. The cellular elements of innate immunity in Drosophila, the hemocytes, have been characterized by morphological criteria, molecular markers, and cell-type-specific immunological markers. Here we suggest that an MiET1 GFP-reporter ...
journal_title：Immunology letters
pub_type： 信件
doi：10.1016/j.imlet.2009.08.004
更新日期：2009-09-22 00:00:00
abstract：:Recent data suggests that autoimmune factors play an important role in the pathogenesis of atherosclerosis. In this context several autoantigens have been shown to elicit an immune response that results in accelerated atherosclerotic plaque formation. In the present study, we investigated whether elevated titers of an...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(99)00050-4
更新日期：1999-06-01 00:00:00
abstract：:Rabbit anti-ovalbumin antibodies were found to bind to Swiss NIH 3T3 fibroblasts by indirect immunofluorescence, and to induce DNA synthesis when these cells were arrested in G0 phase of their replicating cycle (G0-S activity). The proof that these effects were related to the ovalbumin paratopes is based on the follow...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90069-1
更新日期：1987-05-01 00:00:00
abstract：:Autoimmune hepatitis (AIH) is a chronic liver disease mediated by immunity, and could lead to liver fibrosis and hepatocellular carcinoma. However, the mechanisms for breaking hepatic tolerance and driving AIH still remain elusive. We herein reported that the non-specific liver inflammation triggered by carbon tetrach...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2019.11.010
更新日期：2020-02-01 00:00:00
abstract：:Coenzyme Q10 (CoQ10) is a lipid-soluble antioxidant synthesized in human body. This enzyme promotes immune system function and can be used as a dietary supplement. Rheumatoid arthritis (RA) is an autoimmune disease leading to chronic joint inflammation. RA results in severe destruction of cartilage and disability. Thi...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2015.05.012
更新日期：2015-08-01 00:00:00
abstract：:CD8 T cells are strongly induced in response to certain strains of vaccinia virus (VACV) and the generation of this population is tightly regulated by two Tumor Necrosis Factor (TNF)/TNFR superfamily members, OX40 (CD134) and CD27. In this study, we examined the role of another member of the TNFR superfamily, 4-1BB (C...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2011.10.008
更新日期：2012-01-30 00:00:00
abstract：:Clinical immunology is in the Netherlands a separate clinical specialty within internal medicine and pediatrics. Clinical immunologists work closely together with nephrologists, rheumatologists and many other medical specialists. Apart from research and teaching, clinical immunologists are taking care of patients with...
journal_title：Immunology letters
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.imlet.2014.10.008
更新日期：2014-12-01 00:00:00
abstract：:Over the last two decades HIV-1 has spread worldwide and has now surpassed malaria as the leading cause of infectious disease mortality in adults (http://www.who.int/infectious-disease-report/pages/ch1text.html). The clinical course and outcome of HIV-1 infection are highly variable among individuals. Most individuals...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/s0165-2478(01)00275-9
更新日期：2001-11-01 00:00:00
abstract：:The peripheral B-cell pool is in dynamic equilibrium and is controlled by a variety of factors. The rate of generation of B cells can influence both the composition and size of the peripheral B-cell compartment. Mice deficient for lambda5 gene expression have a block in early B-cell development leading to a markedly r...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.05.013
更新日期：2005-11-15 00:00:00
abstract：:A rapid, sensitive and simple method is provided for detecting Bence-Jones proteins in unconcentrated urine by electrosyneresis. This is based on the fact that the free light-chains, similar to the intact immunoglobulin molecules, form complexes with albumin under the effect of glutaraldehyde. Consequently, the origin...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(83)90005-6
更新日期：1983-04-01 00:00:00
abstract：:T cells utilize the vascular adhesion molecule E-selectin to enter inflamed skin. T cells identified by the mAb HECA-452 [cutaneous lymphocyte-associated antigen (CLA) T cells] are enriched in E-selectin ligand expressing cells. However, the proportion of CLA(+) T cells reactive with an E-selectin/Fc chimeric construc...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2006.12.002
更新日期：2007-02-15 00:00:00
abstract：:Peripheral blood from 11 newly diagnosed patients with insulin-dependent diabetes mellitus (IDDM) was studied for the proportion of monoclonal antibody (HNK 1, Leu 7) defined natural killer (NK) cells using a fluorescence-activated cell sorter analyzer. The proportion of Leu 7+ cells in patients with IDDM (7.0 +/- 4.0...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90056-7
更新日期：1984-01-01 00:00:00
abstract：:Lck is the principal signal-generating tyrosine kinase of the T cell activation mechanism. We have previously demonstrated that induced Lck activation outside of lipid rafts (LR) results in the rapid translocation of a fraction of Lck to LR. While this translocation predicates the subsequent production of IL-2, the me...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2012.01.001
更新日期：2012-02-29 00:00:00
abstract：:Administration of cyclosporin A (CS-A; 25 mg/kg daily) to rats from the time of immunization with ovalbumin (OVA) in complete Freund's adjuvant abolished the production of anti-OVA antibodies, including IgE. Cyclophosphamide (Cy; 150 mg/kg) given 2 days before immunization also inhibited specific antibody production b...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90017-3
更新日期：1985-01-01 00:00:00
abstract：:We have explored the requirements for the induction of the N-formyl-methionyl-leucyl-phenylalanine (FMLP) response in Daudi cells after anti-immunoglobulin treatment. Our results indicate that (a) induction of responsiveness to FMLP was observed in Daudi only after crosslinking of surface immunoglobulin by anti-immuno...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(92)90110-a
更新日期：1992-04-01 00:00:00
abstract：:Cytokine induced killer (CIK) cells have a powerful tumor cells killing activity both in vitro and in vivo and transfusion of these cells have become an adjuvant treatment for tumors. CIK cells are induced and amplified from peripheral blood mononuclear cells (PBMCs) with multiple cytokines. As CD4+CD25bri regulatory ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.11.009
更新日期：2017-01-01 00:00:00
abstract：:Protective immunity against Salmonella infection is known to require CD4 Th1 cells and B cells, but the role of MHC class-I-restricted CD8 T cells is less clear. Previous studies have suggested that CD8 T cells participate in secondary, but not primary, bacterial clearance. However, these studies have used experimenta...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2012.10.009
更新日期：2012-12-17 00:00:00
abstract：:A broad array of biological responses including cell polarization, movement, immune and inflammatory responses, as well as prevention of HIV-1 infection, are triggered by the chemokines, a family of secreted and structurally related chemoattractant proteins that bind to class A-specific seven-transmembrane receptors l...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2012.04.012
更新日期：2012-07-30 00:00:00
abstract：:Interleukin-35 (IL-35) is a novel anti-inflammatory cytokine and has been shown to play an important role in maintaining immune homeostasis. However, the effect of IL-35 on human asthma remains unclear. The present study is to investigate the expression and significance of IL-35 in childhood asthma. Forty-one asthmati...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.06.002
更新日期：2014-11-01 00:00:00
abstract：:The physiologically occurring tetrapeptide, tuftsin (Thr-Lys-Pro-Arg), was examined for its effects on guinea pig peritoneal macrophages. Adherent macrophages (møo) were exposed to tuftsin at concentrations ranging from 10(8) to 10(6) M, and the release of oxygen radicals and the arachidonic acid cyclo-oxygenation pro...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(83)90021-4
更新日期：1983-01-01 00:00:00
abstract：:The present study was designed to investigate whether human equivalents of murine T helper cell subsets can be demonstrated by propagation of peripheral blood lymphocytes (PBL) with either recombinant human (rh) interleukin (IL) 2 or rhIL4 in the presence of neutralising antibodies. Cells of both cultures, termed T-IL...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90142-w
更新日期：1991-02-01 00:00:00
abstract：:Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by the destruction of insulin-secreting β cells upon autoreactive T cell attack. Oral administration of autoantigens is an attractive approach to treating T1DM, but an effective carrier should be used in order to protect antigens. Lactococcu...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.04.008
更新日期：2016-06-01 00:00:00
