Abstract：
:A majority of natural killer (NK) cells constitutively express intermediate affinity IL2 receptors made of beta gamma chains and respond by way of enhanced cytokine secretion. However, alterations in cytokine sensitivity of purified NK cells with respect to cytokine secretion during immunosenescence have not been examined before. In view of the major immunomodulatory role of IL2 and the anti-tumor effects of interferon gamma (IFN-gamma), we have investigated the recombinant human IL2-induced NK cell secretion of IFN-gamma in vitro. After an 18-h activation period, the secretion of IFN-gamma by the peripheral blood NK cells from the elderly was severely impaired at 80 U/ml of IL2 and above. At an optimal dose of IL2 (960 U/ml). NK cells from young and elderly showed a mean 11- and 3-fold increase in secretion, respectively. Under similar conditions, purified T cells did not respond to IL2. However, the sensitivity of NK cells to the same inductive ligand, IL2, towards a different function i.e., cytotoxic activity, was not significantly impaired in the aged. It is possible that the cytokine secretory deficiency of senescent NK cells might be an additional mechanism which could favor the establishment of tumors and viral infections in the elderly. However, as discussed here, our findings do offer alternate explanations and a potential target for experimental immunotherapy.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Krishnaraj R,Bhooma Tdoi
10.1016/0165-2478(96)02519-9subject
Has Abstractpub_date
1996-04-01 00:00:00pages
59-63issue
1-2eissn
0165-2478issn
1879-0542pii
0165-2478(96)02519-9journal_volume
50pub_type
杂志文章abstract：:Sera from 2 subacute sclerosing panencephalitis (SSPE) patients were absorbed with a concentrated preparation of measles virus. Measles-specific IgG was eluted from the precipitates containing measles antigen-antibody complex. These IgGs, when subjected to immunofixation after isoelectric focusing showed a number of o...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90002-5
更新日期：1982-02-01 00:00:00
abstract：:Many types of cells in the immune system have been found to produce nitric oxide (NO), which performs multiplex functions. However, in myelin basic protein peptide 68-86 (MBP 68-86)-induced experimental autoimmune encephalomyelitis (EAE) in Lewis rats, we found that elevated NO production was generated from spleen cel...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00154-1
更新日期：2000-03-01 00:00:00
abstract：:A consensus motif for a bovine major histocompatibility complex (MHC) class I molecule, A20, was derived from parainfluenza type-3 (PI-3) virus-infected muscle-derived fibroblast cells and peripheral blood leukocytes by extraction of the naturally processed peptides from MHC class I molecules by treatment with TFA and...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)00244-l
更新日期：1995-02-01 00:00:00
abstract：BACKGROUND:Vitamin D (vitD) is involved in important regulatory functions of the innate and adaptive immune system. So, it has been hypothesized that vitD might influence the course of atopic dermatitis (AD). Also obesity may have impact on immune system. The aim of our study was to investigate vitamin D status and bod...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.11.004
更新日期：2017-01-01 00:00:00
abstract：:The influence of human recombinant granulocyte-macrophage colony-stimulating factor (rH GM-CSF) on respiratory burst response of isolated human neutrophils was examined. Preincubation of cells with rH GM-CSF significantly increased the respiratory burst in response to formyl-methionyl-leucyl-phenylalanine (FMLP), meas...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(93)90114-h
更新日期：1993-09-01 00:00:00
abstract：:Interleukin-35 (IL-35) is a novel anti-inflammatory cytokine and has been shown to play an important role in maintaining immune homeostasis. However, the effect of IL-35 on human asthma remains unclear. The present study is to investigate the expression and significance of IL-35 in childhood asthma. Forty-one asthmati...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.06.002
更新日期：2014-11-01 00:00:00
abstract：:Recent data have shown that piperlongumine (PL), an important component of Piper longum fruits, is known to possess anti-inflammatory and vascular-protective activities. This study aimed to examine the therapeutic effects and underlying mechanisms of PL on lupus-prone MRL-Fas(lpr) mice. Female MRL-Fas(lpr) mice were i...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.05.001
更新日期：2014-09-01 00:00:00
abstract：:Lymphocytes obtained from thymus and spleens of 1-6 week old White Leghorn cockerels, untreated or immunized twice with sheep red blood cells (SRBC), were cultured with common T-cell mitogens in serial dilutions and/or different concentrations of bovine prolactin (PRL). [3H]Thymidine incorporation in newly synthesized...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90044-q
更新日期：1990-06-01 00:00:00
abstract：:The physiological role(s) of fetuin, a protein present in plasma and many tissues of developing animals at levels much higher than in the adult, is unknown. Here we show that fetuin can modify the responses of macrophages to lipopolysaccharide (LPS) stimulation. At concentrations of fetuin in the medium, corresponding...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00126-0
更新日期：1998-01-01 00:00:00
abstract：:Atopic dermatitis (AD) and allergic contact dermatitis (ACD) are common skin inflammatory conditions. B and T cells are strongly implicated in allergic contact hypersensitivity (CHS) conditions. Activation of IgD B-cell receptor (BCR) by anti-IgD stimulation depletes mature B cells and modulates T-helper cell type 1/2...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2018.09.008
更新日期：2018-11-01 00:00:00
abstract：:A fragment of non-glycosylated E2 antigen of classical swine fever virus (CSFV), lacking the trans-membrane anchor (TM-) of the native glycoprotein, was produced in recombinant Escherichia coli strain BL21(DE3) in the form of inclusion bodies. These inclusion bodies isolated from the bacteria cells were administrated ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2003.12.001
更新日期：2004-02-15 00:00:00
abstract：:Several recent findings indicate that mouse bone marrow-derived mast cells (BMMC) express RNA encoding interleukin-4 (IL-4) and secrete detectable amounts of IL-4 in response to cross-linking of Fc epsilon RI receptors, Fc gamma R receptors, or to ionomycin. We investigated the desensitization of BMMC from the view po...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90122-8
更新日期：1994-07-01 00:00:00
abstract：:In this study, we examined the cytokine production by human peripheral blood mononuclear cells (PBM) from recipients of orthotopic liver transplants which had been stimulated by donor-specific alloantigen. Levels of interleukin (IL)-2, IL-4, interferon (IFN)-gamma, IL-10 and transforming growth factor (TGF)-beta produ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00061-3
更新日期：1998-09-01 00:00:00
abstract：:The human factor H protein family comprises six plasma glycoproteins. Earlier we described a membranal factor H-related (mFHR) molecule that is expressed by human B lymphoblastoid cell lines and exerts cofactor activity. In our present study we screened human blood cells for the presence of mFHR proteins and further c...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(01)00194-8
更新日期：2001-05-01 00:00:00
abstract：:N-Chlorotaurine (NCT) plays an important role in the human defense system as a main component of long-lived oxidants, and shows bactericidal, fungicidal, and virucidal activity. Besides this role, NCT seems to act regulatory on immunocompetent cells by altering cytokine production. NCT inhibited nitric oxide, TNF-alph...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.03.006
更新日期：2004-05-15 00:00:00
abstract：:Several immunodominant B-cell epitopes of the P. falciparum antigen blood stage Pf155/RESA, a major vaccine candidate antigen, are located in the molecular regions containing amino acid repeats. We started to map Pf155/RESA for T cell reactive epitopes. For this purpose, short synthetic peptides corresponding to the 3...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(88)90147-2
更新日期：1988-11-01 00:00:00
abstract：:Interleukin-21 (IL-21) is a T cell-derived cytokine modulating T cell, B cell, and natural killer cell responses. To determine whether IL-21 contributes to pathologic processes, recombinant IL-21 receptor (R) fusion protein (rhIL-21R-Fc) was examined in mice models of autoimmune arthritis (collagen-induced arthritis)....
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.09.007
更新日期：2015-02-01 00:00:00
abstract：:In the following study we have analyzed cytokine secretion of T-cells of suicidal and non-suicidal depressed patients and healthy controls. It was found that T-cells of suicidal depressed patients have Th1 characteristics, while T-cells of non-suicidal depressed patients have Th2 characteristics. Th1 environment is as...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00145-x
更新日期：1999-04-01 00:00:00
abstract：:Coenzyme Q10 (CoQ10) is a lipid-soluble antioxidant synthesized in human body. This enzyme promotes immune system function and can be used as a dietary supplement. Rheumatoid arthritis (RA) is an autoimmune disease leading to chronic joint inflammation. RA results in severe destruction of cartilage and disability. Thi...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2015.05.012
更新日期：2015-08-01 00:00:00
abstract：:The effect of ageing on thymocyte progenitors in the bone marrow was studied in an in vitro experimental model that permits T lymphocyte development. The model is based on co-culture of BM cells from young and old mice with lymphoid depleted fetal thymus explants. We applied different strategies of thymic colonization...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)00059-x
更新日期：1994-06-01 00:00:00
abstract：:Cultured T lymphocytes from pig blood can be activated by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). Activation is additive with that induced by the mitogenic lectin phytohaemagglutinin (PHA). Activation by TPA differs from that induced by PHA or other mitogenic lectins in that it is not inhibited e...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(83)90063-9
更新日期：1983-01-01 00:00:00
abstract：:An essential key to pathogenicity in Yersinia is the presence of a 70 kb plasmid (pYV) which encodes a type-III secretion system and several virulence outer proteins whose main function is to enable the bacteria to survive in the host. Thus, a specific immune response is needed in which cytokines are engaged. The aim ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.04.007
更新日期：2004-06-15 00:00:00
abstract：:NADPH oxidase 2 is a superoxide-generating enzymatic complex based on the catalytic subunit gp91phox that is also known as Nox2. Initially identified in neutrophils, NADPH oxidase 2 was long considered responsible only for the killing of phagocytized microorganisms. However, advances in knowledge about redox signallin...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2020.02.009
更新日期：2020-05-01 00:00:00
abstract：:It is widely known that mast cells and cytokine TNF-alpha are both involved in inflammatory reactions. Therefore, we have studied whether TNF-alpha can cause histamine secretion from human adenoidal and cutaneous mast cells. The experiments were performed in vitro on mast cells isolated from tissues by enzymatic dispe...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00115-6
更新日期：1997-12-01 00:00:00
abstract：:Potential endogenous ligands for the cysteine rich domain of the murine mannose receptor (MR) have been detected in marginal zone metallophilic macrophages in spleen and subcapsular sinus macrophages in lymph nodes of naive mice by immunohistochemistry using a Fc chimeric protein. Additional labelling was observed in ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00117-5
更新日期：1999-01-01 00:00:00
abstract：:The basic functions of the immune system are protection from pathogens and maintenance of tolerance to self. The maintenance of commensal microbiota at mucosal surfaces adds a layer of complexity to these basic functions. Recent reports suggest follicular helper T cells (Tfh), a CD4(+) T cell subset specialized to pro...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2014.07.015
更新日期：2014-12-01 00:00:00
abstract：:The induction characteristics of major histocompatibility complex (MHC) class I-specific cytotoxic T lymphocytes (CTL) after footpad immunization were studied. Primary CTL were generated in the regional lymph nodes of C57Bl/6 mice by footpad injection with 10(7) irradiated (2000 rad) spleen cells from MHC class I muta...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90073-6
更新日期：1994-10-01 00:00:00
abstract：:Epidermal growth factor receptor (EGFR) is an attractive target for the treatment of epithelial cancers. However, EGFR antagonists have low clinical response rates and frequently induce resistance mainly caused by the hypermutation of the extracellular and intracellular domains and the heterodimerization of EGFR. Dime...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.10.011
更新日期：2016-12-01 00:00:00
abstract：:When the random polymer (Glu, Phe)n was added to primary lymph node T cell cultures from mice immunized with (Glu, Lys, Ala) and other immunogens, significant inhibition of [3H]thymidine incorporation was noted. A similar addition of (Glu, Phe)n to murine T cell lines (Fathman) from the above reacting lymph nodes led ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90160-x
更新日期：1987-12-01 00:00:00
abstract：:It remains unclear whether lipopolysaccharide (LPS) pre-treatment, which prevents Th2-type responses via Toll-like receptor 4 (TLR4), inhibits anaphylaxis. To determine the dose-dependent effects of LPS pre-treatment on anaphylactic decreases in rectal temperature caused by ovalbumin (OVA) re-exposure in immunized mic...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2008.03.001
更新日期：2008-06-15 00:00:00
