Clinical immunology--autoimmunity in the Netherlands.

abstract：:A variety of straightforward biochemical techniques have been applied to the analysis of HLA molecules. These techniques centre largely on two components: monoclonal antibodies (mAbs) and gel analysis systems. Although only the basic applications are discussed here, the techniques have broad applications. Monoclonal-g...

journal_title：Immunology letters

authors： Lanchbury JS

更新日期：1991-07-01 00:00:00

abstract：:Estimation of a content of secondary structures from amino acid composition of IL-2 (TCGF), PDGF and transforming protein p28sis of simian sarcoma virus by means of the previously suggested nomograms (V.P. Zav'yalov and A.I. Denesyuk (1982) Immunol. Lett. 4, 7-14) allowed us to conclude that a dominant secondary struc...

journal_title：Immunology letters

authors： Zav'yalov VP,Denesyuk AI

更新日期：1985-01-01 00:00:00

abstract：:Clinical symptoms of COVID-19 include fever, cough, and fatigue which may progress to acute respiratory distress syndrome (ARDS). The main hematological laboratory findings associated with the severe form of disease are represented by lymphopenia and eosinopenia which mostly occur in the elderly population characteriz...

journal_title：Immunology letters

authors： Napoli C,Benincasa G,Criscuolo C,Faenza M,Liberato C,Rusciano M

更新日期：2021-01-06 00:00:00

abstract：:The effect of B cell depletion on the induction and severity of murine experimental autoimmune thyroiditis was investigated. Thirteen CBA mice were given repeated intraperitoneal doses of 700 micrograms purified rabbit anti-mouse Ig antibody from 24 hours to 8 weeks after birth. Controls were given normal rabbit IgG (...

journal_title：Immunology letters

authors： Rayfield LS,Smith TA,Andrews SJ,Bergmeier LA

更新日期：1989-01-15 00:00:00

abstract：:Members of the transforming growth factor beta (TGF-beta) superfamily are soluble factors that regulate a variety of functional responses including proliferation, differentiation, apoptosis and cell cycle, among others, depending not only on the cell type and its differentiation state, but also on the milieu of cytoki...

journal_title：Immunology letters

authors： Licona-Limón P,Soldevila G

更新日期：2007-03-15 00:00:00

abstract：:In recent years, several investigators have shown that transfer of dendritic cells (DC) prevents diabetes development in non-obese diabetic (NOD) mice. Accumulating evidences showing that DC cultured in medium containing fetal calf serum (FCS) can induce a dominant unspecific immune response in tumor models after i.v....

journal_title：Immunology letters

authors： Kadri N,Potiron N,Ouary M,Jegou D,Gouin E,Bach JM,Lieubeau B

更新日期：2007-02-15 00:00:00

abstract：:The attenuated androgen Danazol can partially reverse the biochemical defect and prevent angioedema in patients with inherited C1-inhibitor (C1-INH) deficiency (hereditary angioedema, HAE). Though its clinical effectiveness is independent from significant increase of C1-INH plasma levels, its mechanism of action remai...

journal_title：Immunology letters

authors： Pappalardo E,Zingale LC,Cicardi M

更新日期：2003-05-01 00:00:00

abstract：:Growth is coupled to physiological modifications of the immune system which reaches the functional capabilities according to age-related milestones. Few data are available on the circulating immunoglobulin levels and no data exist on total immunoglobulin light chains in infant macaques. Therefore we studied by a nephe...

journal_title：Immunology letters

authors： Pace M,D'Ovidio MC,Iale E,Strom R,Turillazzi P

更新日期：1996-05-01 00:00:00

abstract：:In several diseases where the immune system plays an important role there has been a tremendous progress in treatment efficacy during the last decades. Based on necessary basic science these improvements are results of rapid, numerous and open-minded clinical trials where pieces of positive results step by step have b...

journal_title：Immunology letters

authors： Ludvigsson J

更新日期：2014-05-01 00:00:00

abstract：:Thirteen synthetic peptides corresponding to different regions of the SV40 large T antigen were used as immunogens after coupling to a carrier protein. All peptide conjugates elicited sera that recognized the inducing peptide. In 10 cases the corresponding sites in the native large T antigen also were recognized, as d...

journal_title：Immunology letters

authors： Friedrich U,Scheidtmann KH,Walter G

更新日期：1986-04-01 00:00:00

abstract：:The influence of human recombinant granulocyte-macrophage colony-stimulating factor (rH GM-CSF) on respiratory burst response of isolated human neutrophils was examined. Preincubation of cells with rH GM-CSF significantly increased the respiratory burst in response to formyl-methionyl-leucyl-phenylalanine (FMLP), meas...

journal_title：Immunology letters

authors： Leino L,Nuutila J,Pelliniemi TT,Rajamäki A

更新日期：1993-09-01 00:00:00

abstract：:Hepatitis B virus (HBV)-specific cytotoxic T lymphocytes (CTLs) are thought to play key roles in viral control and liver damage. We have used HLA-A*02 tetramer complex to human HBV core 18-27 (Tc 18-27), envelope 183-191 (Te 183-191), envelope 335-343 (Te 335-343), and polymerase 575-583 (Tp 575-583) epitopes to chara...

journal_title：Immunology letters

authors： Wu Y,Zhang J,Chen S,Chen A,Wang L,Li J,Zhao T,Zou L,Tang Y,Tingrong L,Wang F

更新日期：2004-04-15 00:00:00

abstract：:Aging is associated to dysfunctional changes in the immune system, a process termed immunosenescence. Elderly individuals usually present chronic low level inflammation, likely as the consequence of continued exposure to antigens combined with poor immune function, increases in production of pro-inflammatory cytokines...

journal_title：Immunology letters

authors： Campos C,Pera A,Lopez-Fernandez I,Alonso C,Tarazona R,Solana R

更新日期：2014-11-01 00:00:00

abstract：:The role of the immunomodulator Protein A (PA) (from Staphylococcus aureus, Cowan I strain) in the control of leishmanial infection was studied in experimental animals. Treatment of Leishmania donovani infected hamsters with PA led to a moderate level of reduction of parasite load in their spleen (68%) and liver (46%)...

journal_title：Immunology letters

authors： Ghose AC,Mookerjee A,Sengupta K,Ghosh AK,Dasgupta S,Ray PK

更新日期：1999-02-01 00:00:00

abstract：:Forkhead box O1 (FoxO1) has a crucial role in the early B cell development. To understand the functional importance of FoxO1 gene in the early B cell expansion, we established a FoxO1 knockdown model using 70Z/3 pre-B cell line. The FoxO1 knockdown 70Z/3 cells (70Z/3-KD cells) showed the down-regulated expression of i...

journal_title：Immunology letters

authors： Li Z,Zhang N,Hui F,Zahid D,Zheng W,Xu X,Li W

更新日期：2019-12-01 00:00:00

abstract：:Psoriasis and psoriatic arthritis (PsA) are common diseases associated with considerable morbidity and disability. Their pathophysiology comprises a dysfunctional stromal-immune cell and cytokine network leading to inflammation of skin, entheses and joints. Recent advances in understanding of disease pathogenesis have...

journal_title：Immunology letters

authors： Hueber AJ,McInnes IB

更新日期：2007-12-15 00:00:00

abstract：:Herein, we summarize the steps of a common scientific path taken by the two Guest Editors, an Anesthesiologist (EA) and an Immunologist (AS), and started 25 years ago at the National Cancer Institute in Rome. When in 1980 WHO codified the usage of opioids for cancer pain relief, it was matter of debate whether only di...

journal_title：Immunology letters

authors： Santoni A,Arcuri E

更新日期：2020-10-01 00:00:00

abstract：:Development of novel bi-functional or even tri-functional Fab-effector fusion proteins would have a great potential in the biomedical sciences. However, the expression of Fab-effector fusion proteins in Escherichia coli is problematic especially when a eukaryotic effector moiety is genetically linked to a Fab due to t...

journal_title：Immunology letters

authors： Kang HJ,Kim HJ,Jung MS,Han JK,Cha SH

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVES:To investigate the associations of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) genes polymorphisms with the susceptibility to AS in Taiwan. METHODS:The polymorphisms of CYP1A1 and MnSOD genes were determined in 70 patients with ankylosing spondylitis (AS) and 93 healthy controls ...

journal_title：Immunology letters

authors： Yen JH,Tsai WC,Chen CJ,Lin CH,Ou TT,Hu CJ,Liu HW

更新日期：2003-08-05 00:00:00

abstract：:Using micro-electrode technique we studied the effects of interleukin-2 (50 ng/ml) on bio-electric activity of rat atrial myocardium under normal conditions and after gradual stretching of the tissue. It was shown that interleukin-2 caused increasing in the duration of action potential at the levels of 25, 50, and 90%...

journal_title：Immunology letters

authors： Aksyonov A,Mitrokhin VM,Mladenov MI

更新日期：2015-09-01 00:00:00

abstract：:Galectin-1 (Gal-1) has been implicated in tumor progression partly via the induction of T-cell apoptosis. However the mechanism of Gal-1 induced T-cell death was mostly studied using recombinant, soluble Gal-1 producing controversial results. To explore the true mechanism of Gal-1 and hence tumor cell-induced T-cell d...

journal_title：Immunology letters

authors： Kovács-Sólyom F,Blaskó A,Fajka-Boja R,Katona RL,Végh L,Novák J,Szebeni GJ,Krenács L,Uher F,Tubak V,Kiss R,Monostori E

更新日期：2010-01-04 00:00:00

abstract：:Coenzyme Q10 (CoQ10) is a lipid-soluble antioxidant synthesized in human body. This enzyme promotes immune system function and can be used as a dietary supplement. Rheumatoid arthritis (RA) is an autoimmune disease leading to chronic joint inflammation. RA results in severe destruction of cartilage and disability. Thi...

journal_title：Immunology letters

authors： Jhun J,Lee SH,Byun JK,Jeong JH,Kim EK,Lee J,Jung YO,Shin D,Park SH,Cho ML

更新日期：2015-08-01 00:00:00

abstract：:This article has been withdrawn at the request of the authors and Guest Editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Immunology letters

authors： Salter RD,Watkins SC

更新日期：2009-10-04 00:00:00

abstract：:Others have reported that a monoclonal anti-human IL-2 receptor antibody (anti-CD25) specifically binds a membrane receptor on Xenopus laevis PHA-induced and paraformaldehyde-fixed splenic blasts. In this paper, we present evidence suggesting that this binding is an artifact of membrane damage. Specifically, significa...

journal_title：Immunology letters

authors： Haynes L,Moynihan JA,Cohen N

更新日期：1990-12-01 00:00:00

abstract：:Foxp3+ Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self. Therefore, it is expected that lower numbers and/or less than optimal function could impact on the functioning of the immune system, and thereby contributing to the development of autoimmune diseases. In the present report, by co...

journal_title：Immunology letters

authors： Godoy GJ,Paira DA,Olivera C,Breser ML,Sanchez LR,Motrich RD,Rivero VE

更新日期：2020-07-01 00:00:00

abstract：:Administration of cyclosporin A (CS-A; 25 mg/kg daily) to rats from the time of immunization with ovalbumin (OVA) in complete Freund's adjuvant abolished the production of anti-OVA antibodies, including IgE. Cyclophosphamide (Cy; 150 mg/kg) given 2 days before immunization also inhibited specific antibody production b...

journal_title：Immunology letters

authors： Thomson AW,Brown PA,Simpson JG,Whiting PH,Davidson RJ

更新日期：1985-01-01 00:00:00

abstract：:Replication-competent retroviruses are not known to encode or induce nuclear antigens that are immunogenic in their natural hosts. We describe here the detection of a human T-lymphotropic virus (type I and type II) associated nuclear antigen (HTLV-NA) by an anticomplement immunofluorescence assay. Antibody to HTLV-NA ...

journal_title：Immunology letters

authors： Lee TH,Essex M,Klein E,Klein G

更新日期：1986-08-01 00:00:00

abstract：:The tryptophan fluorescence properties of two different peptide complexes of the single-chain H-2Kd (SC-Kd) were studied by means of the single-photon counting technique. The latter enables time-resolved measurements of fluorescence intensity and anisotropy decay parameters relevant to structural and dynamic propertie...

journal_title：Immunology letters

authors： Dittes K,Gakamsky DM,Haran G,Haas E,Ojcius DM,Kourilsky P,Pecht I

更新日期：1994-05-01 00:00:00

abstract：:RasGRP1 links TCR signaling to Ras in T cells, while both RasGRP1 and RasGRP3 link BCR signaling to Ras in B cells. T cells deficient in RasGRP1 have defective proliferative responses as do B cells deficient in both RasGRP1 and RasGRP3, confirming the importance of Ras activation in lymphocyte proliferation. While age...

journal_title：Immunology letters

authors： Coughlin JJ,Stang SL,Dower NA,Stone JC

更新日期：2006-05-15 00:00:00

abstract：:Crohn's disease and ulcerative colitis, known together as inflammatory bowel disease (IBD), are severe autoimmune disorders now causing gut inflammation and ulceration, among other symptoms, in up to 1 in 250 people worldwide. Incidence and prevalence of IBD have been increasing dramatically over the past several deca...

journal_title：Immunology letters

authors： Huang H,Vangay P,McKinlay CE,Knights D

更新日期：2014-12-01 00:00:00