Abstract:
:Growth is coupled to physiological modifications of the immune system which reaches the functional capabilities according to age-related milestones. Few data are available on the circulating immunoglobulin levels and no data exist on total immunoglobulin light chains in infant macaques. Therefore we studied by a nephelometric assay, the age-dependent variations of kappa and lambda serum light chains in the experimental animal model Macaca fascicularis during the first 20 months of age. Both kappa and lambda showed a marked increase in their concentrations during the first 7-8 months of life. Infants' light chain levels were anyhow significantly lower than those of the nursing dams and of the control group, never attaining, even at the 20th month, the same concentration as the adult, although the value of the kappa/lambda ratio was apparently the same.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Pace M,D'Ovidio MC,Iale E,Strom R,Turillazzi Pdoi
10.1016/0165-2478(96)02522-9subject
Has Abstractpub_date
1996-05-01 00:00:00pages
139-42issue
3eissn
0165-2478issn
1879-0542pii
0165247896025229journal_volume
50pub_type
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