Abstract:
:To study the mechanism(s) responsible for the appearance of Epstein-Barr virus (EBV)-induced anti-histone autoantibodies, peripheral blood B lymphocytes from healthy donors were infected with EBV and the resulting lymphoblastoid cell lines were tested for secretion of antibodies reacting with histones. It was found that EBV-transformed cells produce IgM antibody reactive with histones and that the frequency of EBV-inducible circulating B lymphocytes that produce antibodies to histones is at least 10(-5). Moreover, in cultures of tonsillar lymphoid cells, the enrichment in CD5+ B lymphocytes increases the percentage of EBV-transformed cultures making anti-histone IgM antibodies. EBV may therefore, also in vivo, induce natural anti-histone antibody by polyclonal B-cell activation without any requirement of antigen to trigger antibody response.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Garzelli C,Incaprera M,Bazzichi A,Manunta M,Rognini F,Falcone Gdoi
10.1016/0165-2478(94)90169-4subject
Has Abstractpub_date
1994-03-01 00:00:00pages
277-82issue
3eissn
0165-2478issn
1879-0542pii
0165-2478(94)90169-4journal_volume
39pub_type
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journal_title:Immunology letters
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更新日期:2014-05-01 00:00:00
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journal_title:Immunology letters
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journal_title:Immunology letters
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更新日期:2000-02-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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journal_title:Immunology letters
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doi:10.1016/j.imlet.2018.11.001
更新日期:2018-09-01 00:00:00
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journal_title:Immunology letters
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