Abstract：
:Umbilical cord blood transplants are associated with a lower incidence of graft-versus-host disease (GVHD) than adult marrow or peripheral blood stem cell transplants, and this could be related to a difference in cytokine production between fetal and adult mononuclear cells after allogeneic stimulation. Mixed lymphocyte reactions (MLRs) involving adult cells were associated with greater interferon-gamma (IFNgamma) secretion than MLRs between cord blood cells, although IL-2 secretion was similar. Experiments in which T cells were separated from accessory cells then recombined in artificial combinations indicated that differences in T cells were primarily responsible for the greater [IFNgamma]:[IL-2] ratios generally found after MLRs involving adult cells compared to fetal cells, but accessory cells also influenced this ratio. The cellular basis for the observed difference was not established, but mononuclear cell preparations from cord blood contained significantly higher proportions of CD16(+)56(-) NK-type cells and a CD19(+)1c(+) B cell subset, as well as more CD45 RA-expressing nai;ve T cells.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Kilpatrick DC,Downing I,Palmer JB,Turner MLdoi
10.1016/j.imlet.2003.10.004subject
Has Abstractpub_date
2004-01-30 00:00:00pages
55-61issue
1eissn
0165-2478issn
1879-0542pii
S0165247803002505journal_volume
91pub_type
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journal_title：Immunology letters
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pub_type： 杂志文章
doi：10.1016/0165-2478(92)90138-e
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pub_type： 杂志文章
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更新日期：2020-04-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90013-7
更新日期：1987-04-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：2003-02-03 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00266-2
更新日期：2000-11-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2011.01.010
更新日期：2011-05-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(02)00198-0
更新日期：2002-12-03 00:00:00
