Abstract:
:Sera from 2 subacute sclerosing panencephalitis (SSPE) patients were absorbed with a concentrated preparation of measles virus. Measles-specific IgG was eluted from the precipitates containing measles antigen-antibody complex. These IgGs, when subjected to immunofixation after isoelectric focusing showed a number of oligoclonal bands with one type of light-(L) chain. In urea polyacrylamide gel electrophoresis, the reduced and alkylated measles-specific IgG showed 1-3 homogeneous L-chain bands, whereas IgG isolated from unabsorbed sera and IgG isolated from supernatants of SSPE sera after absorption with measles virus showed a diffuse L-chain band. It can be concluded that in SSPE, measles virus is responsible for the synthesis of L-chain with restricted heterogeneity.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Mehta PD,Thormar Hdoi
10.1016/0165-2478(82)90002-5subject
Has Abstractpub_date
1982-02-01 00:00:00pages
75-8issue
2eissn
0165-2478issn
1879-0542pii
0165-2478(82)90002-5journal_volume
4pub_type
杂志文章abstract::Naive CD4 T cells differentiate into functionally distinct T helper (Th) cells subsets or into regulatory T (Treg) cells in response to the cytokine milieu in which they encounter antigen. A recurring theme in post-thymic CD4 T cell differentiation is the cross-regulation of lineage choice by cytokines and transcripti...
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pub_type: 杂志文章
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journal_title:Immunology letters
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journal_title:Immunology letters
pub_type: 杂志文章
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2010.04.009
更新日期:2010-08-16 00:00:00
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journal_title:Immunology letters
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更新日期:2013-03-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2018.01.004
更新日期:2018-04-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(83)90005-6
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2006.06.001
更新日期:2006-08-15 00:00:00
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更新日期:2013-02-01 00:00:00
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journal_title:Immunology letters
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更新日期:2008-03-15 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1987-04-01 00:00:00
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更新日期:2013-02-01 00:00:00
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journal_title:Immunology letters
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更新日期:2018-11-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
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更新日期:1999-03-01 00:00:00
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更新日期:2003-12-15 00:00:00