Rapidly decreased serum IgG to Campylobacter pylori following elimination of Campylobacter in histological chronic biopsy Campylobacter-positive gastritis.

Abstract:

:The anaerobic bacterium Campylobacter pylori (Cp) is thought to be associated with chronic gastritis. This paper presents clinical data underpinning this view. Five patients with histological chronic gastritis as determined by diagnostic endoscopy, which was associated with Cp as determined by positive biopsy cultures, all possessed statistically raised serum IgG ELISA titers to Cp during a longitudinal period of observation of 15 months. Treatment with the antibiotics amoxycillin (clamoxyl) or colloidal bismuth subcitrate (denol) eliminated Cp within one month. Associated with this, serum IgG ELISA titers were found to decrease sharply and rapidly. Tagamet and spiramycin had little effect. Although the data are preliminary, they support the assumed Cp involvement in chronic gastritis and suggest that specific serum IgG ELISA titers to Cp are useful parameters in monitoring disease status, exceeding bacteriological culture of biopsy specimens in speed and convenience.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

van Bohemen CG,Langenberg ML,Rauws EA,Oudbier J,Weterings E,Zanen HC

doi

10.1016/0165-2478(89)90069-2

subject

Has Abstract

pub_date

1989-01-15 00:00:00

pages

59-61

issue

1

eissn

0165-2478

issn

1879-0542

pii

0165-2478(89)90069-2

journal_volume

20

pub_type

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