Selective enhancement of interleukin 1 beta production in myelomonocytic cell lines by insulin and its related cytokines.

abstract：:Others have reported that a monoclonal anti-human IL-2 receptor antibody (anti-CD25) specifically binds a membrane receptor on Xenopus laevis PHA-induced and paraformaldehyde-fixed splenic blasts. In this paper, we present evidence suggesting that this binding is an artifact of membrane damage. Specifically, significa...

journal_title：Immunology letters

authors： Haynes L,Moynihan JA,Cohen N

更新日期：1990-12-01 00:00:00

abstract：:Humanized mouse models present an important tool for preclinical evaluation of new vaccines and therapeutics. Here we show the human variable repertoire of antibody sequences cloned from a previously described human immune system (HIS) mouse model that possesses functional human CD4+ T cells and B cells, namely HIS-CD...

journal_title：Immunology letters

authors： Nogueira RT,Sahi V,Huang J,Tsuji M

更新日期：2017-08-01 00:00:00

abstract：:Properly balanced cellular responses require both the mutual interactions of soluble factors with cell surface receptors and the crosstalk of intracellular molecules. In particular, immune cells exposed unceasingly to an array of positive and negative stimuli must distinguish between what has to be tolerated and attac...

journal_title：Immunology letters

authors： Leksa V,Ilková A,Vičíková K,Stockinger H

更新日期：2017-10-01 00:00:00

abstract：:Recently, a newly identified human HERV-K18 like endogenous retrovirus (IDDMK(1,2)22) has been associated to the etiology of type I diabetes (IDDM). Although the exact mechanism remains unclear, it was postulated that the 3' end ORF product of the env gene of IDDMK(1,2)22 would trigger a V beta 7-specific human T cell...

journal_title：Immunology letters

authors： Azar GA,Thibodeau J

更新日期：2002-04-01 00:00:00

abstract：:In contrast to defibrinated blood, cells isolated from heparinized blood give lower T-lymphoproliferative responses. Such responses can be also suppressed by addition of heparin to lymphocyte cultures. Platelets inhibit T cell proliferation and B cell differentiation, but their interactions with heparin may produce co...

journal_title：Immunology letters

authors： Górski A,Wasik M,Stepień-Sopniewska B,Glapiński T

更新日期：1991-05-01 00:00:00

abstract：:Chronic rheumatoid arthritis (RA) is characterized by the hyperplasia of synovial tissue, which results from dysregulation of proliferative and antiapoptotic signals transduced in the synovial cells by unknown mechanisms. To identify candidate factors involved in the regulation of synovial hyperplasia, the expression ...

journal_title：Immunology letters

authors： Huh SJ,Paik DJ,Chung HS,Youn J

更新日期：2003-12-15 00:00:00

abstract：:The antibody (Ab) response induced by DNA-based immunization was compared in various strains of inbred, H-2 congenic and outbred mice with different haplotypes of mouse major histocompatibility complex (H-2). Two different plasmid expression vectors encoding Aequorea victoria green fluorescent protein (GFP) or Escheri...

journal_title：Immunology letters

authors： Ito K,Takeuchi Y,Ito K,Kato S

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:The autoimmune regulator (AIRE) regulates autoimmunity and self-antigen expression, such as acetylcholine receptor (AchR), in the thymus. Regulatory T cells (Tregs) can down-regulate autoimmunity, but also promote tumor growth. The objective of this study was to examine the levels of AIRE, AchR, and Foxp3 ex...

journal_title：Immunology letters

authors： Liu Y,Zhang H,Zhang P,Meng F,Chen Y,Wang Y,Yao Y,Qi B

更新日期：2014-09-01 00:00:00

abstract：:Forkhead box O1 (FoxO1) has a crucial role in the early B cell development. To understand the functional importance of FoxO1 gene in the early B cell expansion, we established a FoxO1 knockdown model using 70Z/3 pre-B cell line. The FoxO1 knockdown 70Z/3 cells (70Z/3-KD cells) showed the down-regulated expression of i...

journal_title：Immunology letters

authors： Li Z,Zhang N,Hui F,Zahid D,Zheng W,Xu X,Li W

更新日期：2019-12-01 00:00:00

abstract：AIM:To develop new approach for tumor immunotherapy with VEGFR2-based DNA vaccine. METHODS:VEGFR2 derived from different species were prepared by RT-PCR and subjected to recombinant constructs. The chimeric gene of VEGFR2 was prepared by integrating different epitopes in different species. By transfecting into cells, ...

journal_title：Immunology letters

authors： Yan J,Jia R,Song H,Liu Y,Zhang L,Zhang W,Wang Y,Zhu Y,Yu J

更新日期：2009-09-22 00:00:00

abstract：:Development of active TB is accompanied by immune suppression and the underlining mechanisms have been explored extensively in recent years. MDSCs are a heterogeneous group of immature and progenitor myeloid cells with strong immunosuppressive ability for both natural and adaptive immunity. In our analysis of CD244 (2...

journal_title：Immunology letters

authors： Yang B,Wang X,Jiang J,Zhai F,Cheng X

更新日期：2014-03-01 00:00:00

abstract：:We describe the quantification of the absolute amounts of HLA class II mRNA and class II transactivator (CIITA) mRNA by competitive reverse transcription polymerase chain reaction in cultured synovial fibroblast-like cells (SFC) of patients with rheumatoid arthritis. High basal levels of transcription of class II mRNA...

journal_title：Immunology letters

authors： Navarrete Santos A,Riemann D,Thiele K,Kehlen A,Navarrete Santos A,Langner J

更新日期：1997-06-01 00:00:00

abstract：:Adrenaline has been shown to inhibit the release of tumor necrosis factor (TNF) elicited by lipopolysaccharide (LPS) when tested in vitro on cultured human blood cells and rat macrophages. In this report we have examined the effect of the in vivo administration of adrenaline on TNF serum levels induced by LPS. In agre...

journal_title：Immunology letters

authors： Monastra G,Secchi EF

更新日期：1993-10-01 00:00:00

abstract：:Interleukin 1 beta (IL1 beta) is an inducible polypeptide with many roles in host defence and homoeostasis. It has also been implicated as a mediator of infectious, inflammatory and autoimmune diseases, and the kinetics of its production are relevant to an understanding of the pathogenesis of these conditions. We repo...

journal_title：Immunology letters

authors： di Giovine FS,Symons JA,Duff GW

更新日期：1991-08-01 00:00:00

abstract：:Peripheral blood from 11 newly diagnosed patients with insulin-dependent diabetes mellitus (IDDM) was studied for the proportion of monoclonal antibody (HNK 1, Leu 7) defined natural killer (NK) cells using a fluorescence-activated cell sorter analyzer. The proportion of Leu 7+ cells in patients with IDDM (7.0 +/- 4.0...

journal_title：Immunology letters

authors： Chandy KG,Charles MA,Buckingham B,Waldeck N,Kershnar A,Gupta S

更新日期：1984-01-01 00:00:00

abstract：:Peanut agglutinin (PNA), a D-galactose specific lectin, agglutinated 10-18% of lymphocytes isolated from tonsils of 3- to 6-yr-old children. PNA+ cells were found to be mainly B lymphocytes showing a 9.6 times higher specific activity of DNA polymerase alpha compared to the PNA- cells. The specific activity of deoxycy...

journal_title：Immunology letters

authors： Taljanidisz J,Spasokukotskaja T,Sasvári-Székely M,Antoni F,Staub M

更新日期：1987-06-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) is usually known as an immunosuppressive cytokine, but we and others have shown stimulatory effects of TGF-beta on activation of Th2 T-lymphocytes. In the present investigation we have studied the effect of TGF-beta1 on phosphorylation of ERK, a MAP-kinase downstream of the R...

journal_title：Immunology letters

authors： Schiött A,Sjögren HO,Lindvall M

更新日期：2000-06-01 00:00:00

abstract：:In transplant rejection, graft versus host or autoimmune diseases T cells are mediating the pathophysiological processes. Compared to unspecific pharmacological immune suppression specific inhibition of those T cells, that are involved in the disease, would be an alternative and attractive approach. T cells are activa...

journal_title：Immunology letters

authors： Neumann F,Sturm C,Hülsmeyer M,Dauth N,Guillaume P,Luescher IF,Pfreundschuh M,Held G

更新日期：2009-08-15 00:00:00

abstract：:Complement factor I (CFI) deficiency is typically associated to recurrent infections with encapsulated microorganisms and, less commonly, to autoimmunity. We report a 53-years old male who, in a routine control for non-alcoholic fatty liver disease, presented a flat beta-2 fraction at the capillary protein electropher...

journal_title：Immunology letters

authors： Franco-Jarava C,Colobran R,Mestre-Torres J,Vargas V,Pujol-Borrell R,Hernández-González M

更新日期：2016-06-01 00:00:00

abstract：:Two crucial mediators of monocyte activation by lipopolysaccharide (LPS) are the acute phase plasma factor, lipopolysaccharide binding protein (LBP) and cell-surface-expressed CD14. Whether macrophage (M phi) recognized and respond to LPS in a similar manner is unknown. Here we show that human monocyte-derived M phi r...

journal_title：Immunology letters

authors： Jungi TW,Brcic M,Eperon S

更新日期：1996-12-01 00:00:00

abstract：:Mature B cells express a single immunoglobulin Fc receptor, FcgammaRIIB, that functions to block downstream signaling by co-aggregated antigen receptors. Co-aggregation of receptors is essential because BCR activated kinases must phosphorylate FcgammaRIIB to recruit SHIP and mediate inhibitory signals. Pre-B cells als...

journal_title：Immunology letters

authors： Brauweiler AM,Cambier JC

更新日期：2004-03-29 00:00:00

abstract：:Vogt-Koyanagi-Harada disease is an autoimmune systemic disorder. In Vogt-Koyanagi-Harada disease, inflammatory disorders occur in multiple organs containing melanocytes, including uvea (resulting in acute bilateral panuveitis), skin (resulting in vitiligo and alopecia), central nervous system (resulting in meningitis)...

journal_title：Immunology letters

authors： Yamada K,Senju S,Shinohara T,Nakatsura T,Murata Y,Ishihara M,Nakamura S,Ohno S,Negi A,Nishimura Y

更新日期：2001-10-01 00:00:00

abstract：:The effects of interferon-alpha (IFN-alpha), INF-gamma, transforming growth factor beta (TGF-beta) and dexamethasone on low-affinity Fc receptors for IgE (Fc epsilon R2/CD23) expression on a human eosinophilic leukemia cell line, Eol-3, were examined. Fc epsilon R2/CD23 expression was enhanced by both IFN-alpha and IF...

journal_title：Immunology letters

authors： Watanabe H,Kawabe T,Yodoi J,Tanaka M,Kim KM,Nambu M,Tsuruta S,Morita M,Yorifuji T,Mayumi M

更新日期：1990-09-01 00:00:00

abstract：:RasGRP1 links TCR signaling to Ras in T cells, while both RasGRP1 and RasGRP3 link BCR signaling to Ras in B cells. T cells deficient in RasGRP1 have defective proliferative responses as do B cells deficient in both RasGRP1 and RasGRP3, confirming the importance of Ras activation in lymphocyte proliferation. While age...

journal_title：Immunology letters

authors： Coughlin JJ,Stang SL,Dower NA,Stone JC

更新日期：2006-05-15 00:00:00

abstract：:Activation of the NF-κB pathway is causally linked to initiation and progression of diverse cancers. Therefore, IKKβ, the key regulatory kinase of the canonical NF-κB pathway, should be a logical target for cancer treatment. However, existing IKKβ inhibitors are known to induce paradoxical immune activation, which lim...

journal_title：Immunology letters

authors： Maroni D,Rana S,Mukhopadhyay C,Natarajan A,Naramura M

更新日期：2015-12-01 00:00:00

abstract：:A novel mutant strain of rats, LEC, exhibits an arrest of T-cell maturation from CD4+CD8+ to CD4+CD8- but not the CD4-CD8+ cells in the thymus. Nevertheless, CD4+T cells arise in lymph nodes of LEC rats, implying extrathymic T-cell maturation. We analyzed the variable (V) and junctional region diversity of T-cell rece...

journal_title：Immunology letters

authors： Muramatsu Y,Agui T,Sakai T,Yamada T,Matsumoto K

更新日期：1995-03-01 00:00:00

abstract：:Within the 3' end of nucleotide sequence of human adult T-cell leukaemia virus (ATLV) four small open frames in various phases were found previously. The frames code for 10,000-, 11,000-, 12,000- and 27,000-dalton polypeptides, one of which can be responsible for virus transforming activity. By means of methods of pre...

journal_title：Immunology letters

authors： Zav'yalov VP,Denesyuk AI

更新日期：1987-01-01 00:00:00

abstract：:Thymocyte conditioned medium (TCM) was prepared using 2 lots of fetal calf, and 1 lot each of horse and rabbit sera. The 4 TCM and the respective sera alone were compared in their ability to support primary in vitro sensitization to sheep red blood cells (SRBC) as assayed by direct plaque formation. As would be expect...

journal_title：Immunology letters

authors： White LL,Smith RA

更新日期：1987-01-01 00:00:00

abstract：:Recently, we determined the molecular locations on BoNT/A of the antigenic regions recognized by blocking Abs of cervical dystonia patients immunoresistant to BoNT/A treatment. In the present work we tested the possibility of reducing the levels of the Ab response against immunodominant antigenic sites on the heavy ch...

journal_title：Immunology letters

authors： Dolimbek BZ,Aoki KR,Atassi MZ

更新日期：2011-06-30 00:00:00

abstract：:Disease-modifying osteoarthritis (OA) therapy is not yet available. Several adjuvant therapies have demonstrated promising results in the treatment of OA. The present study aimed to investigate the therapeutic effects and underlying mechanisms of a combination of Lactobacillus acidophilus, vitamin B, and curcumin in t...

journal_title：Immunology letters

authors： Jhun J,Min HK,Na HS,Kwon JY,Ryu J,Cho KH,Choi J,Jung K,Lee SY,Kim SJ,Yang CW,Park SH,Cho ML

更新日期：2020-12-01 00:00:00