Transforming growth factor beta and dexamethasone suppress the expression of Fc epsilon receptor 2 (CD23) on a human eosinophilic cell line EoL-3.

abstract：:RASI-1 is a novel matrix metalloproteinase which we isolated from an expression cDNA library representing the mRNA of an inflamed synovium obtained from a patient with rheumatoid arthritis (RA). To investigate the involvement of RASI-1 in the pathology of RA, we examined synovial specimens from RA patients with antibo...

journal_title：Immunology letters

authors： Kolb C,Mauch S,Peter HH,Krawinkel U,Sedlacek R

更新日期：1997-06-01 00:00:00

abstract：:Controversy exists concerning the role of Toll-like receptors and MyD88 in immunity to tuberculosis (TB). This mini-review argues that (i) Toll-like receptors are not essential for an effective immune response against TB, (ii) MyD88 is essential, but not because it transduces signals from TLRs, (iii) adaptive immunity...

journal_title：Immunology letters

authors： Reiling N,Ehlers S,Hölscher C

更新日期：2008-02-15 00:00:00

abstract：:Luminol-dependent chemiluminescence (CL) triggered by mineral dust in rabbit alveolar macrophages depended on superoxide production as revealed by inhibition by superoxide dismutase and ferricytochrome c. The contribution of superoxide changed in the course of CL peak between 80-20%. The effects of ferricytochrome c w...

journal_title：Immunology letters

authors： Wilhelm J,Vilím V,Brzák P

更新日期：1987-08-01 00:00:00

abstract：:It is widely known that mast cells and cytokine TNF-alpha are both involved in inflammatory reactions. Therefore, we have studied whether TNF-alpha can cause histamine secretion from human adenoidal and cutaneous mast cells. The experiments were performed in vitro on mast cells isolated from tissues by enzymatic dispe...

journal_title：Immunology letters

authors： Brzezińska-Błaszczyk E,Pietrzak A

更新日期：1997-12-01 00:00:00

abstract：:Tuberculosis (TB) is a leading cause of global mortality due to infectious diseases. Expression of cyclooxygenase-2 (COX-2) acts as an important influencing factor favoring bacillary survival during TB infection. In this study, we investigated the Mycobacterium tuberculosis proteins recognized by sera from TB patient ...

journal_title：Immunology letters

authors： Zhao JW,Sun ZQ,Zhang XY,Zhang Y,Liu J,Ye J,Chen CC,Samten B,Wang HH,Guo XK,Zhang SL

更新日期：2014-09-01 00:00:00

abstract：:The mechanism of cytolysis by natural killer cells has been shown to involve a soluble lytic factor - the natural killer cytotoxic factor (NKCF). We have investigated the generation of NKCF on exposure of subpopulations of human blood lymphocytes to autologous B lymphocytes and EBV infected B lymphocytes (BEBV), and t...

journal_title：Immunology letters

authors： Saranath D,Masucci MG,Klein E

更新日期：1986-03-01 00:00:00

abstract：:Cellular membranes contain microdomains known as 'lipid rafts' or detergent-insoluble microdomains (DRM), enriched in cholesterol and sphingolipids. DRM can play an important role in many cellular processes, including signal transduction, cytoskeletal organization, and pathogen entry. Many receptors like T cell recept...

journal_title：Immunology letters

authors： Beekman JM,van der Linden JA,van de Winkel JG,Leusen JH

更新日期：2008-03-15 00:00:00

abstract：:Peanut agglutinin (PNA), a D-galactose specific lectin, agglutinated 10-18% of lymphocytes isolated from tonsils of 3- to 6-yr-old children. PNA+ cells were found to be mainly B lymphocytes showing a 9.6 times higher specific activity of DNA polymerase alpha compared to the PNA- cells. The specific activity of deoxycy...

journal_title：Immunology letters

authors： Taljanidisz J,Spasokukotskaja T,Sasvári-Székely M,Antoni F,Staub M

更新日期：1987-06-01 00:00:00

abstract：:Antibodies reactive with native double stranded DNA are characteristic of the chronic inflammatory disease systemic lupus erythematosus. Native DNA is however, a poor immunogen and the mechanism of anti-DNA antibody production is incompletely understood. Modification of DNA can increase its immunogenicity and in infla...

journal_title：Immunology letters

authors： Blount S,Griffiths HR,Staines NA,Lunec J

更新日期：1992-10-01 00:00:00

abstract：:We have studied the autocrine regulation of essential expression of the intercellular adhesion molecule-1 (ICAM-1) on 8 transitional cell carcinoma (TCC) cell lines (histopathological grades 1-3). The constitutive expression of ICAM-1 was regulated by soluble factors in an autocrine fashion. These factors were produce...

journal_title：Immunology letters

authors： Alexandroff AB,Jackson AM,Esuvaranathan K,Prescott S,James K

更新日期：1994-05-01 00:00:00

abstract：:The thymus contains a low frequency of B cells, about 0.1-0.5% of total population of thymocytes that were shown to contribute in thymic negative selection. The fact that B cells in the periphery have been contributed in the generation of the T regulatory cell compartment emerged the idea that this process may indeed ...

journal_title：Immunology letters

authors： Mohammed Ali HH,Drela N

更新日期：2017-05-01 00:00:00

abstract：:Serum antibodies reactive with intermediate filaments of the cytoskeleton (anti-IF antibodies) are often present in infectious mononucleosis, some other viral diseases, and rheumatoid arthritis. The mechanism of their production is not known, but it is possible that the formation of this and other autoantibodies resul...

journal_title：Immunology letters

authors： Mortazavi-Milani SM,Stierle HE,Holborow EJ

更新日期：1982-10-01 00:00:00

abstract：:Activation of the NF-κB pathway is causally linked to initiation and progression of diverse cancers. Therefore, IKKβ, the key regulatory kinase of the canonical NF-κB pathway, should be a logical target for cancer treatment. However, existing IKKβ inhibitors are known to induce paradoxical immune activation, which lim...

journal_title：Immunology letters

authors： Maroni D,Rana S,Mukhopadhyay C,Natarajan A,Naramura M

更新日期：2015-12-01 00:00:00

abstract：:Multiple activation signals (including antigen, co-stimulation, and cytokines) during T-cell priming affect the subsequent generation of memory T cells, whose survival is maintained by IL-7 and IL-15. Since the IL-7 receptor is highly expressed not only on the surface of memory T cells but also on naïve T cells, we pr...

journal_title：Immunology letters

authors： Guo Z,Wang G,Miyahara Y,Khattar M,Linkes SP,Wang C,Xia J,Pan Y,Chen W,He X,Stepkowski SM

更新日期：2010-02-16 00:00:00

abstract：:When the random polymer (Glu, Phe)n was added to primary lymph node T cell cultures from mice immunized with (Glu, Lys, Ala) and other immunogens, significant inhibition of [3H]thymidine incorporation was noted. A similar addition of (Glu, Phe)n to murine T cell lines (Fathman) from the above reacting lymph nodes led ...

journal_title：Immunology letters

authors： Maurer PH,Liu DC,Grun JL

更新日期：1987-12-01 00:00:00

abstract：:Antibody-dependent and spontaneous lymphocytotoxicity of blood mononuclear cells from 15 patients with chronic renal failure was studied in allogeneic K-562 and xenogeneic chicken erythrocyte test systems. Both antibody-dependent and spontaneous cytotoxic activities were significantly decreased in uremic patients as c...

journal_title：Immunology letters

authors： Láng I,Taraba I,Petrányi G

更新日期：1981-11-01 00:00:00

abstract：BACKGROUND:Takayasu's arteritis (TA) is a chronic inflammation that affects the large vessels; however, its etiology is still unknown. Human serum paraoxonase hydrolyzes oxidized lipids into low-density lipoproteins and could therefore be associated with the prevalence of inflammation processes. Therefore, the purpose ...

journal_title：Immunology letters

authors： Huesca-Gómez C,Soto ME,Castrejón-Téllez V,Pérez-Méndez O,Gamboa R

更新日期：2013-04-01 00:00:00

abstract：:The earliest T-cell precursor population in the adult mouse thymus (low CD4 precursors) may be divided into 85% of cells expressing surface Mel-14 (LECAM-1, the lymphocyte homing receptor) and 15% of cells which are Mel-14. To date, this is the only surface marker for which we have found this population to be heteroge...

journal_title：Immunology letters

authors： Wu L,D'Amico A

更新日期：1994-05-01 00:00:00

abstract：:Interferon-gamma (IFN-gamma) stimulates the development of monocytic features in human myeloid precursors. Because transcriptional regulation of IFN-gamma and the pituitary hormone prolactin (PRL) has been described to involve common Jak-STAT pathways, we addressed here the question of whether PRL plays a role in mono...

journal_title：Immunology letters

authors： Sedo A,Van Weyenbergh J,Rouillard D,Bauvois B

更新日期：1996-11-01 00:00:00

abstract：:The quasimonoclonal (QM) mouse provides a model to analyze B cell selection because major B cell antigen receptors (BCR) are composed of the knockin V(H)DJ(H) 17.2.25 (V(H)T) encoded H chain and the lambda1 or lambda2 L chain, thereby being specific for (4-hydoxy-3-nitrophenyl)acetyl (NP). We have reported that during...

journal_title：Immunology letters

authors： Kouyama E,Nishikawa Y,Okazawa T,Magari M,Ohmori H,Kanayama N

更新日期：2007-03-15 00:00:00

abstract：:A variety of straightforward biochemical techniques have been applied to the analysis of HLA molecules. These techniques centre largely on two components: monoclonal antibodies (mAbs) and gel analysis systems. Although only the basic applications are discussed here, the techniques have broad applications. Monoclonal-g...

journal_title：Immunology letters

authors： Lanchbury JS

更新日期：1991-07-01 00:00:00

abstract：:Intravenous infusion of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF), induced fatal anaphylactoid reaction in guinea pigs, or reversible thrombocytopenia and leucopenia. These reactions showed a maximal depression of circulating platelet and leucocyte numbers...

journal_title：Immunology letters

authors： Demopoulos CA,Tsabikakis GE,Kapoulas VM

更新日期：1981-08-01 00:00:00

abstract：:The assessment strategy for implementation of the Union of European Medical Specialists' (UEMS) Immunology curriculum is based on a combination of formative and summative assessments. The strategy comprises a combination of workplace-based assessments and knowledge-based assessments designed to ensure acquisition of k...

journal_title：Immunology letters

authors： Choremi-Papadopoulou E,Faure GC,Malenica B,Misbah SA,Zlabinger GJ

更新日期：2009-06-30 00:00:00

abstract：:Inflammatory bowel disease (IBD) is caused by chronic inflammation of the gastrointestinal tract. The pathogenesis of IBD remains unclear. The inflammation is associated with activation of T helper (Th) lymphocytes and chronic production of inflammatory cytokines. Ro60 suppresses the expression of tumor necrosis facto...

journal_title：Immunology letters

authors： Kim SY,Park MJ,Kwon JE,Choi SY,Seo HB,Jung KA,Choi JW,Baek JA,Lee HH,Lee BI,Park SH,Cho ML

更新日期：2018-09-01 00:00:00

abstract：INTRODUCTION:Considering the role of interleukin (IL)-9 and IL-9-producing Th9 cells in pathogenesis of autoimmune diseases, this study aimed to evaluate serum IL-9 levels in patients with Behçet's disease (BD) compared to healthy subjects and to assess whether there is an association between serum IL-9 levels and dise...

journal_title：Immunology letters

authors： Nouri-Vaskeh M,Malek Mahdavi A,Khabbazi A,Jadideslam G

更新日期：2019-07-01 00:00:00

abstract：:Two of the better characterized antimicrobial mechanisms displayed by human neutrophils are the reactive oxygen species (ROS) production and the induction of apoptosis. Their importance in mycobacterial infections is, however, controversial and we aimed to analyze them simultaneously in neutrophils infected with eithe...

journal_title：Immunology letters

authors： González-Cortés C,Reyes-Ruvalcaba D,Diez-Tascón C,Rivero-Lezcano OM

更新日期：2009-09-22 00:00:00

abstract：:Coelomic fluid from the earthworm Lumbricus terrestris is known to contain immunoactive cells and molecules involved in immune defense. To assess the ability of such molecules to form precipitating complexes with anti-human immunoglobulins, radial immunodiffusion experiments were conducted. Anti-human IgG, anti-human ...

journal_title：Immunology letters

authors： Eyambe GS

更新日期：1993-02-01 00:00:00

abstract：:The production of interleukin 1 (IL-1) by lipopolysaccharide (LPS)-stimulated myelomonocytic cell lines ML-1, THP-1 and PL-21 was significantly enhanced by the addition of insulin, insulin-like growth factor (IGF)-I or IGF-II into the cell cultures. The IL-1 activity in the supernatants from cell cultures stimulated w...

journal_title：Immunology letters

authors： Holán V,Minowada J

更新日期：1992-12-01 00:00:00

abstract：:We examined the alphabeta T cell receptor (TCR) repertoire of naturally occurring CD4+CD25+ regulatory T (Treg) cells isolated from healthy human blood. Three-color FACS analysis demonstrated that the usage of variable region segments of TCRbeta chains by CD4+CD25+ cells did not differ from those of CD4+CD25- cells. C...

journal_title：Immunology letters

authors： Fujishima M,Hirokawa M,Fujishima N,Sawada K

更新日期：2005-07-15 00:00:00

abstract：:Over the last two decades HIV-1 has spread worldwide and has now surpassed malaria as the leading cause of infectious disease mortality in adults (http://www.who.int/infectious-disease-report/pages/ch1text.html). The clinical course and outcome of HIV-1 infection are highly variable among individuals. Most individuals...

journal_title：Immunology letters

authors： Carrington M,Nelson G,O'Brien SJ

更新日期：2001-11-01 00:00:00