Tumor necrosis factor alpha (TNF-alpha) activates human adenoidal and cutaneous mast cells to histamine secretion.

abstract：:Classical swine fever (CSF) and pseudorabies (PR) are both major infectious diseases of pigs, causing enormous economic losses to the swine industry in many countries. A marker vaccine that enables differentiation of infected from vaccinated animals (DIVA) is highly desirable for control and eradication of these two d...

journal_title：Immunology letters

authors： Lei JL,Xia SL,Wang Y,Du M,Xiang GT,Cong X,Luo Y,Li LF,Zhang L,Yu J,Hu Y,Qiu HJ,Sun Y

更新日期：2016-06-01 00:00:00

abstract：:The spontaneous migration in vitro, production of T cell migration inhibitory factor (TIF) and the response to TIF of OKT4+ and OKT8+ human T cell subsets were studied. The OKT4+ lymphocytes migrated far better than the OKT8+ cells although the movement of both subsets was comparably inhibited by TIF. The OKT8+ subset...

journal_title：Immunology letters

authors： Kowalczyk D,Pryjma J,Zembala M

更新日期：1986-08-01 00:00:00

abstract：:Part of pathogen-associated molecular pattern (PAMP) and damage-associated molecular pattern (DAMP) activate antigen-presenting cells through Toll-like receptors (TLRs) to initiate immune responses. However, controversy remains if TLR4 mediates DAMP signaling due to the confounding effects of potential LPS contaminati...

journal_title：Immunology letters

authors： Lee KM,Seong SY

更新日期：2009-06-30 00:00:00

abstract：:In several diseases where the immune system plays an important role there has been a tremendous progress in treatment efficacy during the last decades. Based on necessary basic science these improvements are results of rapid, numerous and open-minded clinical trials where pieces of positive results step by step have b...

journal_title：Immunology letters

authors： Ludvigsson J

更新日期：2014-05-01 00:00:00

abstract：:The biological activity of six synthetic peptides of the 124-144 region of the human interferon alpha-2 (IFN alpha-2) molecule was studied. Peptides were examined for their ability to inhibit mitogen induced proliferation of human blood cells in vitro. Only the peptide corresponding to the amino acid sequence 124-138 ...

journal_title：Immunology letters

authors： Danilkovich AV,Freze KV,Shevalier AF,Samukov VV,Kirkin AF,Gusev MV

更新日期：1992-01-01 00:00:00

abstract：:This study tested the hypothesis that the Vδ3 subset of human γδ T cells, like their Vδ2 counterparts, can influence differentiation, antibody secretion and cytokine production by B cells. Vδ3 T cells constitute a minor subset of peripheral blood lymphocytes but are enriched in the liver and gut and are expanded in pa...

journal_title：Immunology letters

authors： Petrasca A,Melo AM,Breen EP,Doherty DG

更新日期：2018-04-01 00:00:00

abstract：:In early seventies "natural killer (NK) cells", a third lymphocyte subset was discovered that revealed an unexpected ability to kill syngeneic and allogeneic tumor targets, thus emerging as the most potent non-specific cytotoxic cells in both human and mouse. Decades of research revealed the multifaceted nature of the...

journal_title：Immunology letters

authors： Bellora F,Castriconi R,Dondero A,Carrega P,Mantovani A,Ferlazzo G,Moretta A,Bottino C

更新日期：2014-10-01 00:00:00

abstract：:We have examined whether the interaction of peptide-loaded MHC molecules on the surface of B-cells with antigen-specific T-cell receptors (TCRs) enhances Ig secretion in the presence of other antigen-independent interactions in vitro. B-cells specific for region 25-40 of beta-lactoglobulin (beta-LG) were stimulated in...

journal_title：Immunology letters

authors： Takahashi Y,Ametani A,Totsuka M,Fujine K,Tsuji NM,Kurisaki J,Kaminogawa S

更新日期：1998-04-01 00:00:00

abstract：:Circulating lymphocytes were enumerated in 25 patients with coeliac disease and in 24 healthy donors by immunofluorescent staining using monoclonal antibodies for T cell surface phenotypic markers T11 (mature), T4 (helper) and T8 (suppressor) or polyvalent antisera for surface immunoglobulins (B cells). Proportions of...

journal_title：Immunology letters

authors： Vĕtvicka V,Tlaskalová-Hogenová H,Fric P,Brochier J

更新日期：1986-08-01 00:00:00

abstract：:The previously called "hemoglobinase" Sm32 molecule of the adult worm of Schistosoma mansoni was chemically synthesized in 22 polymeric peptides based on the t-boc strategy. Their immunogenicity was evaluated in rabbits to which a mixture of five to six peptides of 20 amino acids long were given in three doses with Fr...

journal_title：Immunology letters

authors： Noya O,Alarcón de Noya B,Guzmán F,Bermúdez H

更新日期：2003-09-08 00:00:00

abstract：:Non-Alcoholic Fatty Liver Disease (NALD) is considering a hepatic manifestation of metabolic syndrome. Although the pathogenesis of NALD is not completely understood, insulin resistance and inflammatory cytokines are implicated. Considering that component C5 is a central mediator of inflammation, we investigated the r...

journal_title：Immunology letters

authors： Bavia L,Cogliati B,Dettoni JB,Ferreira Alves VA,Isaac L

更新日期：2016-09-01 00:00:00

abstract：:Innate lymphoid cells (ILC) have only recently been recognized as a separate entity of the lymphoid lineage. Their subpopulations share common characteristics in terms of early development and major transcriptional circuitry with their related cousins of the T cell world. It is currently hypothesized that ILCs constit...

journal_title：Immunology letters

authors： Gronke K,Kofoed-Nielsen M,Diefenbach A

更新日期：2016-11-01 00:00:00

abstract：:Interferon-gamma (IFN-gamma) stimulates the development of monocytic features in human myeloid precursors. Because transcriptional regulation of IFN-gamma and the pituitary hormone prolactin (PRL) has been described to involve common Jak-STAT pathways, we addressed here the question of whether PRL plays a role in mono...

journal_title：Immunology letters

authors： Sedo A,Van Weyenbergh J,Rouillard D,Bauvois B

更新日期：1996-11-01 00:00:00

abstract：:The ability of immune checkpoint inhibitors (ICIs) to reactivate the killing function of the immune system to tumor cells has led to long lasting immune response presenting highly promising clinical advances. Recently, immune checkpoint inhibitors related resistance due to the specialized tumor microenvironment has al...

journal_title：Immunology letters

authors： Li Y,Liu J,Gao L,Liu Y,Meng F,Li X,Qin FX

更新日期：2020-04-01 00:00:00

abstract：:The presence of dendritic cells (DCs) in mycobacterium-containing granulomas, as well as in other granuloma-inducing diseases, is beginning to be appreciated. This review will summarize what is known about DCs with regards to the granuloma and discuss the potential roles DCs may be playing during mycobacterial infecti...

journal_title：Immunology letters

authors： Schreiber HA,Sandor M

更新日期：2010-05-04 00:00:00

abstract：:The role of the immunomodulator Protein A (PA) (from Staphylococcus aureus, Cowan I strain) in the control of leishmanial infection was studied in experimental animals. Treatment of Leishmania donovani infected hamsters with PA led to a moderate level of reduction of parasite load in their spleen (68%) and liver (46%)...

journal_title：Immunology letters

authors： Ghose AC,Mookerjee A,Sengupta K,Ghosh AK,Dasgupta S,Ray PK

更新日期：1999-02-01 00:00:00

abstract：:Previously we reported that a mega-dose of Vitamin C enhanced the initial stage of delayed-type hypersensitivity reaction in Balb/c mice. In this study its effects were further evaluated as follows. Mice were administered Vitamin C intraperitoneally at 0.625 mg/day or at 5mg/day for variable days before, during, or af...

journal_title：Immunology letters

authors： Noh K,Lim H,Moon SK,Kang JS,Lee WJ,Lee D,Hwang YI

更新日期：2005-04-15 00:00:00

abstract：:Coelomic fluid from the earthworm Lumbricus terrestris is known to contain immunoactive cells and molecules involved in immune defense. To assess the ability of such molecules to form precipitating complexes with anti-human immunoglobulins, radial immunodiffusion experiments were conducted. Anti-human IgG, anti-human ...

journal_title：Immunology letters

authors： Eyambe GS

更新日期：1993-02-01 00:00:00

abstract：:Thirteen synthetic peptides corresponding to different regions of the SV40 large T antigen were used as immunogens after coupling to a carrier protein. All peptide conjugates elicited sera that recognized the inducing peptide. In 10 cases the corresponding sites in the native large T antigen also were recognized, as d...

journal_title：Immunology letters

authors： Friedrich U,Scheidtmann KH,Walter G

更新日期：1986-04-01 00:00:00

abstract：:The physiologically occurring tetrapeptide, tuftsin (Thr-Lys-Pro-Arg), was examined for its effects on guinea pig peritoneal macrophages. Adherent macrophages (møo) were exposed to tuftsin at concentrations ranging from 10(8) to 10(6) M, and the release of oxygen radicals and the arachidonic acid cyclo-oxygenation pro...

journal_title：Immunology letters

authors： Hartung HP,Toyka KV

更新日期：1983-01-01 00:00:00

abstract：:The human homologue of 4-1BB (H4-1BB) cDNA was isolated from PMA plus ionomycin-treated human peripheral T-cell cDNA libraries. The amino acid sequence deduced from the nucleotide sequence showed that the protein is composed of 255 amino acids with 2 potential N-linked glycosylation sites. The molecular weight of its ...

journal_title：Immunology letters

authors： Zhou Z,Kim S,Hurtado J,Lee ZH,Kim KK,Pollok KE,Kwon BS

更新日期：1995-02-01 00:00:00

abstract：:Clinical symptoms of COVID-19 include fever, cough, and fatigue which may progress to acute respiratory distress syndrome (ARDS). The main hematological laboratory findings associated with the severe form of disease are represented by lymphopenia and eosinopenia which mostly occur in the elderly population characteriz...

journal_title：Immunology letters

authors： Napoli C,Benincasa G,Criscuolo C,Faenza M,Liberato C,Rusciano M

更新日期：2021-01-06 00:00:00

abstract：:For more than two decades, chloroquine (CQ) was largely and deliberately used as first choice drug for malaria treatment. However, worldwide increasing cases of resistant strains of Plasmodium have hampered its use. Nevertheless, CQ has recently been tested as adjunct therapy in several inflammatory situations, such a...

journal_title：Immunology letters

authors： Thomé R,Lopes SC,Costa FT,Verinaud L

更新日期：2013-06-01 00:00:00

abstract：:The phenomenon of virus neutralization is a function of three variables: the antibody (Ab), the virus and the target cell. Variation in any one of these parameters may drastically affect the results of assays for neutralization. In focusing on the virus as a variable in assays for the neutralization of HIV-1, it has b...

journal_title：Immunology letters

authors： Zolla-Pazner S

更新日期：1996-06-01 00:00:00

abstract：:Heat-killed Saccharomyces cerevisiae (HKSC) is an agonist for Dectin-1, a major fungal cell wall β-glucan receptor. We previously reported that HKSC selectively enhances IgG1 production by LPS-activated mouse B cells. To determine if this IgG1 selectivity is caused by selective IgG1 class switching, we performed RT-PC...

journal_title：Immunology letters

authors： Seo BS,Park HY,Yoon HK,Yoo YC,Lee J,Park SR

更新日期：2016-10-01 00:00:00

abstract：:When IL-4 mRNA was distinguished from mRNA encoding its antagonist, the splice variant IL-4delta2, it was found to correlate directly with expression of TLR2 in fresh peripheral blood mononuclear cells (PBMCs) from normal donors (p=0.0013). Similarly IL-4 mRNA was high when TLR2 mRNA was abundant compared to levels of...

journal_title：Immunology letters

authors： Chang JS,Dheda K,Huggett JF,Kim LU,Zumla A,Rook GA

更新日期：2006-08-15 00:00:00

abstract：:A theoretical analysis of experimental data is presented in this mini-review on non-random homo- and hetero-associations of cell surface receptors, which can be recruited in the plasma membrane or at the surface of the rough endoplasmic reticulum during the protein synthesis. In the latter case, the likely genetic ori...

journal_title：Immunology letters

authors： Damjanovich S,Mátyus L,Damjanovich L,Bene L,Jenei A,Matkó J,Gáspár R,Szöllösi J

更新日期：2002-06-03 00:00:00

abstract：:Cloned human T-cell lines were produced by limiting dilution of lymphocytes alloactivated in mixed leukocyte cultures, followed by expansion of clonal progeny with interleukin 2. Selected clones were analyzed for cell-mediated cytotoxicity (CTX) against a variety of targets susceptible or resistant to lytic attack by ...

journal_title：Immunology letters

authors： Pawelec G,Hadam M,Müller C,Wernet P

更新日期：1982-05-01 00:00:00

abstract：:The quasimonoclonal (QM) mouse provides a model to analyze B cell selection because major B cell antigen receptors (BCR) are composed of the knockin V(H)DJ(H) 17.2.25 (V(H)T) encoded H chain and the lambda1 or lambda2 L chain, thereby being specific for (4-hydoxy-3-nitrophenyl)acetyl (NP). We have reported that during...

journal_title：Immunology letters

authors： Kouyama E,Nishikawa Y,Okazawa T,Magari M,Ohmori H,Kanayama N

更新日期：2007-03-15 00:00:00

abstract：:We have studied the mechanisms involved in the activation or suppression of the immune response by the tumor cells, which is also dependent on the site of tumor transplantation. AK-5 tumor cells when transplanted s.c. activated peritoneal macrophages through the induction of different cytokines, whereas tumor cells wh...

journal_title：Immunology letters

authors： Mitra R,Bhaumik S,Khar A

更新日期：2002-07-03 00:00:00