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Chloroquine: modes of action of an undervalued drug.

Abstract：

:For more than two decades, chloroquine (CQ) was largely and deliberately used as first choice drug for malaria treatment. However, worldwide increasing cases of resistant strains of Plasmodium have hampered its use. Nevertheless, CQ has recently been tested as adjunct therapy in several inflammatory situations, such as rheumatoid arthritis and transplantation procedures, presenting intriguing and promising results. In this review, we discuss recent findings and CQ mechanisms of action vis-à-vis its use as a broad adjunct therapy.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Thomé R,Lopes SC,Costa FT,Verinaud L

doi

10.1016/j.imlet.2013.07.004

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

50-7

issue

1-2

eissn

0165-2478

issn

1879-0542

pii

S0165-2478(13)00096-5

journal_volume

153

pub_type

杂志文章,评审

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