Synergistic effect of prolactin on IFN-gamma-mediated growth arrest in human monoblastic cells: correlation with the up-regulation of IFN-gamma receptor gene expression.

Abstract:

:Interferon-gamma (IFN-gamma) stimulates the development of monocytic features in human myeloid precursors. Because transcriptional regulation of IFN-gamma and the pituitary hormone prolactin (PRL) has been described to involve common Jak-STAT pathways, we addressed here the question of whether PRL plays a role in monoblastic (U937) cell growth and macrophage maturation. In contrast to IFN-gamma, PRL did not affect U937 cell growth nor induction of differentiation as assessed by the unchanged cell surface expression of maturation markers CD11b and HLA-DR class II. However, PRL in synergy with IFN-gamma inhibited, in a time- and dose-dependence, proliferation of U937 cells without influencing their maturation induced by IFN-gamma. IFN-gamma and PRL both affected the expression of the IFN-gamma receptor (IFN-gamma R) gene by increasing IFN-gamma R mRNA levels. The rise in IFN-gamma R transcripts was accompanied by a low but significant release of IL-6 which has previously been shown to stabilize IFN-gamma R mRNA. Moreover, a transient increase in surface expression of IFN-gamma R was observed in U937 cells treated by IFN-gamma alone or in combination with PRL, whereas no apparent modulation of cell surface IFN-gamma R was observed in cells treated with PRL. Lastly, PRL did not induce transcriptional activation in IFN-gamma inducible IRF-1 and Fc gamma RI genes in U937 cells. Together, our data indicate that IL-6 secretion and increased expression of the IFN-gamma R gene correlate with U937 cell growth arrest induced by IFN-gamma and PRL, probably through a signaling mechanism which does not involve the Stat 1/IRF-1 pathway.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Sedo A,Van Weyenbergh J,Rouillard D,Bauvois B

doi

10.1016/s0165-2478(96)02622-3

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

125-30

issue

2-3

eissn

0165-2478

issn

1879-0542

pii

S0165-2478(96)02622-3

journal_volume

53

pub_type

杂志文章
  • Activation of purified allogeneic CD4(+) T cells by rat bone marrow-derived dendritic cells induces concurrent secretion of IFN-gamma, IL-4, and IL-10.

    abstract::Dendritic cells (DCs) are highly specialized antigen-presenting cells that play a key role in the initiation and regulation of immune responses. The ability of DCs to process antigens and the outcome of their interaction with T cells are largely dependent on phenotype as well as maturation state of DCs. In this study,...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/j.imlet.2005.05.012

    authors: Janelidze S,Enell K,Visse E,Darabi A,Salford LG,Siesjö P

    更新日期:2005-11-15 00:00:00

  • Does mosaicism of the plasma membrane at molecular and higher hierarchical levels in human lymphocytes carry information on the immediate history of cells?

    abstract::A theoretical analysis of experimental data is presented in this mini-review on non-random homo- and hetero-associations of cell surface receptors, which can be recruited in the plasma membrane or at the surface of the rough endoplasmic reticulum during the protein synthesis. In the latter case, the likely genetic ori...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-2478(02)00024-x

    authors: Damjanovich S,Mátyus L,Damjanovich L,Bene L,Jenei A,Matkó J,Gáspár R,Szöllösi J

    更新日期:2002-06-03 00:00:00

  • Recombinant interleukin-2 inhibits growth of human tumor xenografts in congenitally athymic mice.

    abstract::Administration of human recombinant interleukin-2 (RIL-2) into congenitally athymic (nu/nu) mice carrying subcutaneous transplants of HeLa, HU 609T and T24B human carcinoma cells partially inhibited growth of the human tumor xenografts. In vitro activation of nu/nu spleen cells with human RIL-2 resulted in generation ...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/0165-2478(87)90013-7

    authors: Bubeník J,Kieler J,Tromholt V,Indrová M,Lotzová E

    更新日期:1987-04-01 00:00:00

  • Down-regulation of murine B lymphocyte growth: arrest of B cells in G1 underlies immunosuppression induced by an IgM antibody.

    abstract::Previous studies have demonstrated that culture supernatants of LPS-stimulated murine splenic B lymphocytes (BLPSSN) are able to inhibit the growth of freshly isolated B cells via an IgM antibody. In this work we investigated the progress of LPS-activated B lymphocytes through the cell cycle in the presence of this an...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/0165-2478(92)90070-5

    authors: Uher F,Mihalik R,Alonso ME,Gergely J

    更新日期:1992-08-01 00:00:00

  • Oral administration of Lactococcus lactis-expressing heat shock protein 65 and tandemly repeated IA2P2 prevents type 1 diabetes in NOD mice.

    abstract::Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by the destruction of insulin-secreting β cells upon autoreactive T cell attack. Oral administration of autoantigens is an attractive approach to treating T1DM, but an effective carrier should be used in order to protect antigens. Lactococcu...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/j.imlet.2016.04.008

    authors: Liu KF,Liu XR,Li GL,Lu SP,Jin L,Wu J

    更新日期:2016-06-01 00:00:00

  • Role of alpha-adrenergic stimulus in stress-induced modulation of body temperature, blood glucose and innate immunity.

    abstract::Mice were exposed to restraint stress for 3h. During this period, low body temperature (hypothermia, 39 degrees C-->less than 37 degrees C) and high blood glucose levels (hyperglycemia, 150 mg/dl-->up to 220 mg/dl) were simultaneously induced. Reflecting a stress-induced phenomenon, blood levels of catecholamines incr...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/j.imlet.2007.09.010

    authors: Watanabe M,Tomiyama-Miyaji C,Kainuma E,Inoue M,Kuwano Y,Ren H,Shen J,Abo T

    更新日期:2008-01-15 00:00:00

  • Day 3 Poly (I:C)-activated dendritic cells generated in CellGro for use in cancer immunotherapy trials are fully comparable to standard Day 5 DCs.

    abstract:BACKGROUND:Dendritic cells (DCs) are professional antigen-presenting cells that are capable of inducing immune responses. DC-based vaccines are normally generated using a standard 5- to 7-day protocol. To shorten the DC-based vaccine production for use in cancer immunotherapy, we have developed a fast DC protocol by co...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/j.imlet.2014.03.010

    authors: Truxova I,Pokorna K,Kloudova K,Partlova S,Spisek R,Fucikova J

    更新日期:2014-07-01 00:00:00

  • Safety and immunogenicity of a gE/gI/TK gene-deleted pseudorabies virus variant expressing the E2 protein of classical swine fever virus in pigs.

    abstract::Classical swine fever (CSF) and pseudorabies (PR) are both major infectious diseases of pigs, causing enormous economic losses to the swine industry in many countries. A marker vaccine that enables differentiation of infected from vaccinated animals (DIVA) is highly desirable for control and eradication of these two d...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/j.imlet.2016.04.014

    authors: Lei JL,Xia SL,Wang Y,Du M,Xiang GT,Cong X,Luo Y,Li LF,Zhang L,Yu J,Hu Y,Qiu HJ,Sun Y

    更新日期:2016-06-01 00:00:00

  • Immunostimulatory activity of lactotransferrin and maturation of CD4- CD8- murine thymocytes.

    abstract::Human milk lactotransferrin at a concentration ranging from 1 to 10 micrograms/ml stimulated up to 5 times the humoral immune response to sheep red blood cells, expressed as the number of plaque-forming cells, when injected into mice 3 h before immunization. Further, lactotransferrin-treated thymocytes given intraveno...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/0165-2478(91)90099-v

    authors: Zimecki M,Mazurier J,Machnicki M,Wieczorek Z,Montreuil J,Spik G

    更新日期:1991-09-01 00:00:00

  • The role of TGF-beta superfamily during T cell development: new insights.

    abstract::Members of the transforming growth factor beta (TGF-beta) superfamily are soluble factors that regulate a variety of functional responses including proliferation, differentiation, apoptosis and cell cycle, among others, depending not only on the cell type and its differentiation state, but also on the milieu of cytoki...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.imlet.2006.12.010

    authors: Licona-Limón P,Soldevila G

    更新日期:2007-03-15 00:00:00

  • Studies on natural cytotoxicity of human monocytes in viral hepatitis.

    abstract::Studies on natural cytotoxicity of peripheral blood monocytes were conducted in patients with acute viral hepatitis B, patients with chronic aggressive hepatitis etiopathogenically linked to viral hepatitis B, and in asymptomatic carriers of HBs antigen. In the majority of cases of viral hepatitis in the acute stage o...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/0165-2478(85)90016-1

    authors: Kiczka W,Szkaradkiewicz A,Flieger J

    更新日期:1985-01-01 00:00:00

  • Two screening methods show different antigen recognition patterns for four monoclonal antibodies to Candida albicans cell surface.

    abstract::Four murine monoclonal antibodies (mAbs) showing similar reactivity with a cell-wall extract and mannan preparation obtained from Candida albicans were examined for epitope specificity. An enzyme-linked immunosorbent assay (ELISA) was used to determine total mAb binding to extracted cell-wall antigen when each mAb was...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/0165-2478(89)90134-x

    authors: Chaffin WL,Morrow KJ Jr

    更新日期:1989-07-01 00:00:00

  • Macrophages as effector cells in immunity to malaria.

    abstract::Experiments with malaria in mice suggest that protective immunity depends not only on antibody but also on activation of macrophages. Activated macrophages may cause intra-erythrocytic death of parasites by releasing reactive oxygen intermediates and/or tumour necrosis factor. Macrophage activation for both types of p...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审

    doi:10.1016/0165-2478(85)90173-7

    authors: Playfair JH,Dockrell H,Taverne J

    更新日期:1985-01-01 00:00:00

  • Light-chain profiles in sera from patients with subacute sclerosing panencephalitis.

    abstract::Sera from 2 subacute sclerosing panencephalitis (SSPE) patients were absorbed with a concentrated preparation of measles virus. Measles-specific IgG was eluted from the precipitates containing measles antigen-antibody complex. These IgGs, when subjected to immunofixation after isoelectric focusing showed a number of o...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/0165-2478(82)90002-5

    authors: Mehta PD,Thormar H

    更新日期:1982-02-01 00:00:00

  • An exopolysaccharide produced by Geobacillus thermodenitrificans strain B3-72: antiviral activity on immunocompetent cells.

    abstract::The immunomodulatory and antiviral effects of an extracellular polysaccharide (EPS-2), produced by a strain of Geobacillus thermodenitrificans isolated from a shallow marine vent of Vulcano Island (Italy), were evaluated. In the present study, we show for the first time that EPS-2 treatment hinder HSV-2 replication in...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/j.imlet.2009.03.001

    authors: Arena A,Gugliandolo C,Stassi G,Pavone B,Iannello D,Bisignano G,Maugeri TL

    更新日期:2009-04-27 00:00:00

  • Infection with prevalent clinical strains of Mycobacterium tuberculosis leads to differential maturation of monocyte derived dendritic cells.

    abstract::The link between innate and adaptive host immune response to Mycobacterium tuberculosis (M.tb) is driven by dendritic cells (DC). In this study, we examined the ability of prevalent clinical strains from south India (S7, S10) and laboratory strain H37Rv (Rv) to induce maturation of monocyte derived dendritic cells (Mo...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/j.imlet.2008.01.009

    authors: Rajashree P,Das SD

    更新日期:2008-05-15 00:00:00

  • Frequencies of T cells secreting IL-2 and/or IL-4 among unprimed CD4+ populations. Evidence that clones secreting IL-2 and IL-4 give rise to clones which secrete only IL-4.

    abstract::We have utilized a limiting dilution assay, involving a minimum of in vitro culture, to determine the frequencies of CD4+ T cells which have the capacity to secrete IL-2 (Th1), IL-4 (Th2) or IL-2 and IL-4 (Th0). CD4+ lymph node cells obtained from unimmunized mice were found to contain 40% Th1, 34% Th2, and 26% Th0 ce...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/0165-2478(90)90197-x

    authors: Torbett BE,Laxer JA,Glasebrook AL

    更新日期:1990-01-01 00:00:00

  • Establishment and biological activity of a proliferative anti-idiotype-activated T cell line.

    abstract::Antisera were raised in rabbits against a monoclonal antibody (McAb 103) of C3H.SW origin which is specific to the synthetic polypeptide (T,G)-A-L and was shown to express the major idiotypic determinants of conventional anti-(T,G)-A-L antibodies. Antibodies were purified and were shown in a binding assay to recognize...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/0165-2478(85)90130-0

    authors: Axelrod O,Stanislawski M,Mozes E

    更新日期:1985-01-01 00:00:00

  • Characterization of human monoclonal antibodies selected with a hypervariable loop-deleted recombinant HIV-1(IIIB) gp120.

    abstract::Recombinant gp120 of the HIV-1(IIIB) isolate (BH10 clone) has been mutated to form the PR12 protein with the first 74 C-terminal amino acids and the V1, V2 and V3 hypervariable loops deleted. A variety of studies have shown that the CD4 binding domain (CD4bd) is very well exposed in PR12 in contrast to rgp120(LAI). Us...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/s0165-2478(01)00289-9

    authors: Jeffs SA,Gorny MK,Williams C,Revesz K,Volsky B,Burda S,Wang XH,Bandres J,Zolla-Pazner S,Holmes H

    更新日期:2001-12-03 00:00:00

  • Genetic evidence for the involvement of NOTCH4 in rheumatoid arthritis and alopecia areata.

    abstract::To explore the genetic association of single nucleotide polymorphisms (SNPs) in the coding region of the NOTCH4, exon 3 C+1297T and exon 5 A+3063G, in a case-control analysis of 58 rheumatoid arthritis (RA) and 98 alopecia areata (AA) and 100 ethnically matched healthy subjects. NOTCH4 polymorphisms were genotyped by ...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/j.imlet.2013.01.002

    authors: AlFadhli S,Nanda A

    更新日期:2013-02-01 00:00:00

  • Two genetic variants in the promoter region of the CCL5 gene are associated with the risk of acute coronary syndrome and with a lower plasma CCL5 concentration.

    abstract::Acute coronary syndrome (ACS) is a multi-factorial condition with a strong inflammatory component, which is immune-mediated by chemokines. The CCL5 is a chemokine that has been suggested to be an important participant in the development of the atherosclerotic plaque. Therefore, in this work, we evaluated whether three...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/j.imlet.2020.10.006

    authors: Herrera-Maya G,Vargas-Alarcon G,Ramirez-Bello J,Perez-Mendez O,Posadas-Sanchez R,Lopez-Marure R,Granados J,Nieto-Lima B,Fragoso JM

    更新日期:2020-12-01 00:00:00

  • Hepatic phase of malaria is the target of cellular mechanisms induced by the previous and the subsequent stages. A crucial role for liver nonparenchymal cells.

    abstract::Both the sporozoites and the erythrocytic stages can modulate the hepatic phase by cytokines, notably IFN-gamma, TNF and IL-6, either directly or as a result of a cascade of events, and by MHC-restricted and antibody-dependent cell-mediated cytotoxicity. The role played by CD8+ T cells in inducing protective immunity ...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审

    doi:10.1016/0165-2478(90)90093-6

    authors: Mazier D,Rénia L,Nussler A,Pied S,Marussig M,Goma J,Grillot D,Miltgen F,Drapier JC,Corradin G

    更新日期:1990-08-01 00:00:00

  • Down modulation of MHC surface molecules on B cells by suppressive immune complexes obtained from chronic intestinal schistosomiasis patients.

    abstract::Granulomatous inflammation around parasite eggs is the prominent lesion in human schistosomiasis. Studies have suggested the involvement of a series of suppressive mechanisms in the control of this reaction, such as macrophages, cytokines, idiotypic interactions and immune complexes (IC). The studies examine the role ...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/s0165-2478(98)00026-1

    authors: Rezende SA,Gollob KJ,Correa-Oliveira R,Goes AM

    更新日期:1998-06-01 00:00:00

  • The relative density of CD44-positive porcine monocytic cell populations varies between isolations and upon culture and influences susceptibility to infection by African swine fever virus.

    abstract::African swine fever (ASF) virus has been reported to infect cells of the monocyte family, probably macrophage-like cells, but there is variation in the apparent susceptibility of these cells. We have demonstrated that the phenotype and activity of porcine monocytic cells varies between different isolations and also up...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/0165-2478(93)90136-p

    authors: McCullough KC,Schaffner R,Fraefel W,Kihm U

    更新日期:1993-07-01 00:00:00

  • Protein energy malnutrition alters mucosal IgA responses and reduces mucosal vaccine efficacy in mice.

    abstract::Oral vaccine responsiveness is often lower in children from less developed countries. Childhood malnutrition may be associated with poor immune response to oral vaccines. The present study was designed to investigate whether protein energy malnutrition (PEM) impairs B cell immunity and ultimately reduces oral vaccine ...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/j.imlet.2017.08.025

    authors: Rho S,Kim H,Shim SH,Lee SY,Kim MJ,Yang BG,Jang MH,Han BW,Song MK,Czerkinsky C,Kim JO

    更新日期:2017-10-01 00:00:00

  • SH2D1A expression reflects activation of T and NK cells in cord blood lymphocytes infected with EBV and treated with the immunomodulator PSK.

    abstract::We infected umbilical cord blood lymphocytes (CBL) with EBV in vitro. Analysis of the cell population in 3- and 6-day-old cultures showed a relative increase of B cells and outgrowth of B cells after prolonged culture period. The immunomodulator PSK was added to parallel cultures. In these cultures, B cell growth was ...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/s0165-2478(01)00330-3

    authors: Liu A,Klein G,Bandobashi K,Klein E,Nagy N

    更新日期:2002-03-01 00:00:00

  • Impact of B cell/lymphoid stromal cell crosstalk in B-cell physiology and malignancy.

    abstract::Stromal cells have been considered for a long time essentially as a structural component organizing tissue architecture, including those of secondary lymphoid organs. More recently, highly specialized stromal cell subsets were shown to differentially organize immune cell recruitment, survival, and differentiation with...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审

    doi:10.1016/j.imlet.2019.02.005

    authors: Lamaison C,Tarte K

    更新日期:2019-11-01 00:00:00

  • Establishment of human cell lines producing anti-D monoclonal antibodies: identification of Rhesus D antigen.

    abstract::Two cell lines producing monoclonal antibodies have been established from peripheral blood of a negative Rhesus blood donor which has been immunized with positive Rhesus red blood cells. Two monoclonal antibodies Co II 8.8 and Co II 7.12 have been selected. Both are IgG1 antibodies, but recognize different epitopes on...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/0165-2478(86)90046-5

    authors: Paire J,Monestier M,Rigal D,Martel F,Desgranges C

    更新日期:1986-09-01 00:00:00

  • Induction of apoptosis in bone marrow cells by gangliosides produced by a T cell lymphoma.

    abstract::The present study was conducted to investigate the mode of cell death of bone marrow cells (BMC) treated in vivo or in vitro with gangliosides (DLG) derived from a T cell lymphoma, designated as Dalton's lymphoma (DL). BMC undergoing cell death showed morphological features characteristic to apoptosis such as cell shr...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/s0165-2478(00)00156-5

    authors: Bharti AC,Singh SM

    更新日期:2000-04-03 00:00:00

  • Inhibition of HLA B8-restricted recognition by unrelated peptides: evidence for allosteric inhibition.

    abstract::A panel of synthetic peptides representing human lymphocyte antigen (HLA) B8, other class I and class II restricted T cell epitopes and two B cell epitopes, were all able to compete with recognition of a HLA B8 restricted epitope by a cytotoxic T cell clone. Competition was obtained when the competitor peptides were a...

    journal_title:Immunology letters

    pub_type: 杂志文章

    doi:10.1016/0165-2478(91)90048-f

    authors: Fernan A,Burrows SR,Moss DJ,Saul A,Suhrbier A

    更新日期:1991-11-01 00:00:00