Abstract：
:Non-Alcoholic Fatty Liver Disease (NALD) is considering a hepatic manifestation of metabolic syndrome. Although the pathogenesis of NALD is not completely understood, insulin resistance and inflammatory cytokines are implicated. Considering that component C5 is a central mediator of inflammation, we investigated the role of C5 in the establishment of NALD. Eight to ten-week old B6 C5(+) and A/J C5(-) male mice were fed a high fat diet containing glucose (HFDG) for 6 and 10 weeks. We observed that B6 C5(+) mice HFDG-fed for 10 weeks developed hepatomegaly, triglycerides (TG) accumulation, steatosis and enhanced liver TNF-α, IL-6, IL-12p70 and IL-17 levels when compared to A/J C5(-) mice. Next, B6 C5(+) mice were compared with congenic B6 C5(-) mice. Again, B6 C5(+) HFDG-fed mice developed more steatosis, liver centro-lobular inflammation and presented higher levels of liver IL-1β, IL-12p70, IL-17 and TFG-β than B6 C5(-) mice under the same conditions. B6 C5(+) mice HFDG-fed also presented lower concentrations of serum albumin, serum cholesterol, blood leukocytes and liver NO production when compared with B6 C5(-) mice. We concluded that murine C5 contributes effectively to liver steatosis and inflammation in NALD pathogenesis. In addition, C5 is also important to control serum cholesterol and albumin levels in the C57BL/6 genetic background.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Bavia L,Cogliati B,Dettoni JB,Ferreira Alves VA,Isaac Ldoi
10.1016/j.imlet.2016.07.014subject
Has Abstractpub_date
2016-09-01 00:00:00pages
53-61eissn
0165-2478issn
1879-0542pii
S0165-2478(16)30129-8journal_volume
177pub_type
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(88)90070-3
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abstract：:We have previously reported the production of a series of human monoclonal antibodies reacting with mouse mammary tumor viral antigens as well as the human counterpart HuMTV antigen. Against two of these antibodies (B11 and 4.6/6), anti-idiotypic antibodies were generated, which appeared to be the internal image of vi...
journal_title：Immunology letters
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doi：10.1016/0165-2478(92)90090-b
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90044-x
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journal_title：Immunology letters
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journal_title：Immunology letters
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journal_title：Immunology letters
pub_type： 杂志文章
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.02.011
更新日期：2005-07-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90044-q
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90115-7
更新日期：1990-08-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2010.09.016
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journal_title：Immunology letters
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doi：10.1016/j.imlet.2009.05.010
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journal_title：Immunology letters
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journal_title：Immunology letters
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journal_title：Immunology letters
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doi：10.1016/0165-2478(87)90069-1
更新日期：1987-05-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
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更新日期：2014-12-01 00:00:00
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journal_title：Immunology letters
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journal_title：Immunology letters
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doi：10.1016/s0165-2478(97)02696-5
更新日期：1997-03-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90128-2
更新日期：1985-01-01 00:00:00
abstract：:We have mapped a T cell epitope in the circumsporozoite (CS) protein of the murine malaria parasite, Plasmodium yoelii. A 21-mer synthetic peptide corresponding to the amino acid positions 59-79 (referred to as Py1), induced specific proliferation in BALB/c and C57BL/6 mice, and provided help for the production of ant...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90092-5
更新日期：1990-08-01 00:00:00
