Abstract:
:Based on the cerebral malaria coma scale, 39 falciparum malaria autopsy cases from the Hospital for Tropical Diseases, Mahidol University, Bangkok, Thailand were divided into two groups of patients that had either cerebral malaria or non-cerebral malaria. We then studied significant pathological differences, such as parasitized erythrocyte (PRBC) sequestration, ring hemorrhages and cerebral edema, between these two groups in order to investigate the correlation between the clinical coma scale and pathological findings. Patients with a coma grade of 2 and higher were designated as having cerebral malaria, and had erythrocyte PRBC sequestration in cerebral microvessels. Ninety four percent (94%) of cerebral microvessels showed PRBC sequestration when quantitatively analyzed. On the other hand, only 13% of cerebral microvessels showed sequestration in non-cerebral malaria patients with a coma grade of 1 and lower, although some degree of PRBC sequestration was found in 50% of these patients. Our study, therefore, clearly demonstrated that the degree of the PRBC sequestration in cerebral microvessels appeared to correlate closely with the clinical coma scale.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Riganti M,Pongponratn E,Tegoshi T,Looareesuwan S,Punpoowong B,Aikawa Mdoi
10.1016/0165-2478(90)90115-7subject
Has Abstractpub_date
1990-08-01 00:00:00pages
199-205issue
1-3eissn
0165-2478issn
1879-0542pii
0165-2478(90)90115-7journal_volume
25pub_type
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