Abstract:
:Immunization of BALB/c mice (H-2d) with a mixture of major histocompatibility complex (MHC) class I- and MHC class II-restricted synthetic peptides emulsified in incomplete Freund's adjuvant (IFA) induced a high level of specific cytotoxic T lymphocyte (CTL) activity. Peptides 249-260 or 252-260, derived from the circumsporozoite protein of Plasmodium berghei and representing a H-2Kd-restricted CTL epitope, were injected twice subcutaneously or intraperitoneally in BALB/c mice in combination with the tetanus toxin-derived universal T-helper peptide P30 in IFA. No protection was observed after exposure of immunized mice to infected mosquitoes. In contrast, when peptide 252-260-specific CTLs were expanded in vitro and adoptively transferred into naive recipient, mice were partially protected (64%) against a subsequent sporozoite challenge. Furthermore, direct transfer of lymph nodes or spleen cells from mice immunized with the peptide PbCS 252-260 also conferred protection to recipient mice. This protection was long-lasting and similar to that obtained with irradiated sporozoites.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Renggli J,Valmori D,Romero JF,Eberl G,Romero P,Betschart B,Corradin Gdoi
10.1016/0165-2478(95)00043-5subject
Has Abstractpub_date
1995-05-01 00:00:00pages
199-205issue
1-2eissn
0165-2478issn
1879-0542pii
0165-2478(95)00043-5journal_volume
46pub_type
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