Isotype of antibodies responsible for immune lysis in Trypanosoma cruzi infected mice.

Abstract:

:Serum obtained from mice infected with Trypanosoma cruzi have antibodies able to induce immune lysis in presence of complement. Gel filtration in Sephadex G-200 and affinity chromatography with rabbit anti-mouse IgG and protein A-Sepharose showed that the antibodies responsible for the immune serum lytic activity are exclusively located in Ig of IgG isotype, including IgG1, IgG2a, IgG2b and probably IgG3. It is suggested that antibodies responsible for protection against T. cruzi infection and antibodies responsible for immune lysis are the same.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Stefani MM,Takehara HA,Mota I

doi

10.1016/0165-2478(83)90040-8

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

91-7

issue

2

eissn

0165-2478

issn

1879-0542

pii

0165-2478(83)90040-8

journal_volume

7

pub_type

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