Abstract:
:Serum obtained from mice infected with Trypanosoma cruzi have antibodies able to induce immune lysis in presence of complement. Gel filtration in Sephadex G-200 and affinity chromatography with rabbit anti-mouse IgG and protein A-Sepharose showed that the antibodies responsible for the immune serum lytic activity are exclusively located in Ig of IgG isotype, including IgG1, IgG2a, IgG2b and probably IgG3. It is suggested that antibodies responsible for protection against T. cruzi infection and antibodies responsible for immune lysis are the same.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Stefani MM,Takehara HA,Mota Idoi
10.1016/0165-2478(83)90040-8subject
Has Abstractpub_date
1983-01-01 00:00:00pages
91-7issue
2eissn
0165-2478issn
1879-0542pii
0165-2478(83)90040-8journal_volume
7pub_type
杂志文章abstract:UNLABELLED:To study the pathogenic importance of the rheumatoid factor (RF) in rheumatoid arthritis (RA) and to identify genes differentially expressed in patients and healthy individuals, total RNA was isolated from peripheral blood mononuclear cells (PBMC) from eight RF-positive and six RF-negative RA patients, and s...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.03.018
更新日期:2004-05-15 00:00:00
abstract::The effects of cilostazol on stimulating heme oxygenase (HO)-1 expression including signal pathways and suppression of inflammatory cytokines and molecules were studied. Cilostazol stimulation time (1-8 h)- and concentration (1-30 μM)-dependently increased the HO-1 mRNA and protein expression associated with increased...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2011.01.003
更新日期:2011-05-01 00:00:00
abstract::MHC tetramers are used to directly enumerate and visualize the antigen-specific T lymphocyte population of interest by flow cytometry, regardless of the T lymphocyte's functional capacity. Assay sensitivity can be hindered by non-specific binding activity, which is due to the inherent interactions of CD8 and MHC. Poin...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.11.016
更新日期:2005-05-15 00:00:00
abstract::The quasimonoclonal (QM) mouse provides a model to analyze B cell selection because major B cell antigen receptors (BCR) are composed of the knockin V(H)DJ(H) 17.2.25 (V(H)T) encoded H chain and the lambda1 or lambda2 L chain, thereby being specific for (4-hydoxy-3-nitrophenyl)acetyl (NP). We have reported that during...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2006.12.011
更新日期:2007-03-15 00:00:00
abstract::Replication-competent retroviruses are not known to encode or induce nuclear antigens that are immunogenic in their natural hosts. We describe here the detection of a human T-lymphotropic virus (type I and type II) associated nuclear antigen (HTLV-NA) by an anticomplement immunofluorescence assay. Antibody to HTLV-NA ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(86)90120-3
更新日期:1986-08-01 00:00:00
abstract::We report here that Trichosanthin (Tk), a primary active component isolated from a Chinese traditional medicinal herb, Trichosanthes kirilowii, potently inhibits lymphocyte proliferative response in vitro. We found that Tk treatment increased production of the interleukins IL-4 and IL-10, while production of IL-2 and ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2007.03.008
更新日期:2007-05-15 00:00:00
abstract:BACKGROUND:Hereditary angioedema with C1-inhibitor deficiency (C1-INH-HAE) is a rare, autosomal dominant disorder. The characteristic episodes of subcutaneous/submucosal edema formation may be preceded by erythema marginatum (EM) - the occurrence of a 'map-like' pattern on the skin. EM can occur as an isolated finding ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2017.05.015
更新日期:2017-09-01 00:00:00
abstract::We determined the degree of activation of the TNF alpha system and the levels of IL-8 in HIV-1 infection. TNF alpha is one of the most potent agents for the induction of IL-8. TNF alpha may be cleared rapidly from the circulation, however soluble tumor necrosis factor receptor (sTNFR) p75 which is more stable may refl...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(96)02583-7
更新日期:1996-08-01 00:00:00
abstract::ErbB2, a member of the EGF receptor family of tyrosine kinases is overexpressed on many tumor cells of epithelial origin and is the molecular target of trastuzumab (Herceptin), the first humanized antibody used in the therapy of solid tumors. Trastuzumab, which is thought to act, at least in part, by downregulating Er...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2005.11.018
更新日期:2006-04-15 00:00:00
abstract::Despite the prominent progress in understanding cancer immunosurveillance mechanisms, there are some types of problems which have been identified to hinder effective and successful immunotherapy of cancers. Such problems have been ascribed to the tumor abilities in the creation of a tolerant milieu that can impair imm...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2020.01.006
更新日期:2020-04-01 00:00:00
abstract::Control animals and rats infected 90 days earlier, by inoculation of 1 x 10(6) trypomastigotes of Trypanosoma cruzi at weaning, were subjected to adult thymectomy (ATx) or sham operation (S-ATx) and assessed 3 months later for the presence of myocardial lesions and levels of lymph node and spleen T-cell populations. C...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90028-z
更新日期:1993-08-01 00:00:00
abstract::The antischistosomal property of a short course of cyclosporin A (CsA), administered at the time of infection was demonstrated in the rat. In comparison with vehicle-treated controls, no schistosomes were recovered from CsA-treated animals, 18-19 days post infection. Flow cytometric analysis of blood and spleen lympho...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(88)90086-7
更新日期:1988-02-01 00:00:00
abstract::BAFF deficiency in mice impairs B cell development beyond the transitional stage 1 in the spleen and thus severely reduces the size of follicular and marginal zone B cell compartments. Moreover, humoral immune responses in these mice are dramatically impaired. We now addressed the question whether the decrease in matu...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2010.03.007
更新日期:2010-06-15 00:00:00
abstract::The physiologically occurring tetrapeptide, tuftsin (Thr-Lys-Pro-Arg), was examined for its effects on guinea pig peritoneal macrophages. Adherent macrophages (møo) were exposed to tuftsin at concentrations ranging from 10(8) to 10(6) M, and the release of oxygen radicals and the arachidonic acid cyclo-oxygenation pro...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(83)90021-4
更新日期:1983-01-01 00:00:00
abstract::Soluble C3d applied to human blood-derived B lymphocytes inhibited anti-mu, T cell-produced growth factor, and EBV-induced DNA synthesis in serum-free culture. C3d added to the B cell cultures 1 and 2 days after the stimulus, still exerted inhibition, though with gradually diminishing efficiency. C3d, fixed on zymosan...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90175-p
更新日期:1990-10-01 00:00:00
abstract::Naive CD4 T cells differentiate into functionally distinct T helper (Th) cells subsets or into regulatory T (Treg) cells in response to the cytokine milieu in which they encounter antigen. A recurring theme in post-thymic CD4 T cell differentiation is the cross-regulation of lineage choice by cytokines and transcripti...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2008.11.001
更新日期:2009-01-29 00:00:00
abstract::The biological activity of six synthetic peptides of the 124-144 region of the human interferon alpha-2 (IFN alpha-2) molecule was studied. Peptides were examined for their ability to inhibit mitogen induced proliferation of human blood cells in vitro. Only the peptide corresponding to the amino acid sequence 124-138 ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90004-8
更新日期:1992-01-01 00:00:00
abstract::In order to study the effect of interferon alpha on the levels of acute phase complement proteins in vivo, serum concentrations of C9 and C1-inhibitor (C1-INH) were measured in patients with chronic hepatitis C before and 3 months after the beginning of interferon alpha2b therapy. Serum levels of the activation produc...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(00)00183-8
更新日期:2000-05-01 00:00:00
abstract::Innate lymphoid cells (ILC) have only recently been recognized as a separate entity of the lymphoid lineage. Their subpopulations share common characteristics in terms of early development and major transcriptional circuitry with their related cousins of the T cell world. It is currently hypothesized that ILCs constit...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2016.07.004
更新日期:2016-11-01 00:00:00
abstract::Parenteral administration of antigen induces in the earthworms Lumbricus terrestris and Eisenia foetida the formation of antigen-binding protein. Labelled antigen was efficiently digested in the coelomic fluids of both species since the total amount of radioactivity in the coelomic fluids decreased. Antigen internaliz...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90044-3
更新日期:1993-05-01 00:00:00
abstract::Tumor cells express a range of antigens including self-antigens (those whose expression is shared by normal host tissue) and non-self antigens (such as those that arise as a result of mutations in normal cellular genes or in the case of some tumors, viral antigens). Immune responses to both types of antigen have been ...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/s0165-2478(02)00240-7
更新日期:2003-01-22 00:00:00
abstract::Protective immunity against Salmonella infection is known to require CD4 Th1 cells and B cells, but the role of MHC class-I-restricted CD8 T cells is less clear. Previous studies have suggested that CD8 T cells participate in secondary, but not primary, bacterial clearance. However, these studies have used experimenta...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2012.10.009
更新日期:2012-12-17 00:00:00
abstract::Bisphenol A (BPA) is a widely used plasticizer, which came into focus because of its genotoxic and sensitizing potential. Besides its toxic properties, BPA is also well-known for its antioxidant chemical properties. This in vitro study investigated the interference of BPA with interferon-γ (IFN-γ)-induced tryptophan b...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2015.10.006
更新日期:2015-12-01 00:00:00
abstract::Conventional indirect haemagglutination test was performed in rhesus monkey sera (collected from Plasmodium knowlesi infected animals) with and without prior treatment of sera with 2-mercapto-ethanol (2-ME). Surprisingly, many sera samples showed significant enhancement of final titre with 2-ME. The 2-ME enhancement e...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(84)90090-7
更新日期:1984-01-01 00:00:00
abstract::Humans frequently produce serum IgM autoantibodies reactive with T-cell receptor beta chains at a determinant defined by peptides corresponding to the first complementarity determining region. It is likely that this determinant serves as a public idiotype involved in immunoregulation. Following screening of culture su...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90010-y
更新日期:1993-11-01 00:00:00
abstract::Maturation of dendritic cells is a key step during induction of adaptive immune responses. Multiple pathways and factors are involved in the regulation of dendritic cell maturation. Alternative splicing of pre-mRNA, which is regulated by splicing factors, plays an important role in many biological processes, including...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.06.004
更新日期:2013-06-01 00:00:00
abstract::The question is still unresolved whether in insulin-dependent (type I) diabetes T-lymphocytes mediate an autoimmune response towards pancreatic islets. We now present direct evidence in an animal model for autoimmune T-lymphocytes with specificity for islet antigens. Mice of strain C57BL/6 were immunized repeatedly wi...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(85)90090-2
更新日期:1985-01-01 00:00:00
abstract::Leukaemic blood lymphocytes from patients with B prolymphocytic leukaemia express the common acute lymphoblastic leukaemia antigen (CALLA). The in vitro incubation of prolymphocytes with leucocyte conditioned medium produced the acquisition of plasma cell morphology, of intracytoplasmic immunoglobulins and the simulta...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(85)90005-7
更新日期:1985-01-01 00:00:00
abstract::The link between innate and adaptive host immune response to Mycobacterium tuberculosis (M.tb) is driven by dendritic cells (DC). In this study, we examined the ability of prevalent clinical strains from south India (S7, S10) and laboratory strain H37Rv (Rv) to induce maturation of monocyte derived dendritic cells (Mo...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2008.01.009
更新日期:2008-05-15 00:00:00
abstract::When murine BALB/c splenocytes are pretreated for 2 h with different concentrations of 25-hydroxycholesterol (25-HC) or 7 beta-hydroxycholesterol (7-HC), washed and stimulated either with irradiated C57BL/6 splenocytes or with Con A, IL-2 secretion is inhibited in a dose-dependent way as well as the subsequent cell pr...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(86)90067-2
更新日期:1986-11-03 00:00:00