Abstract:
:Tuberculosis is an infectious disease that affects millions of people worldwide with an annual mortality rate of 1.3 million. The mechanisms contributing to the loss of balance of immune responses and progression to active tuberculosis disease are unknown. Although CD4+ and CD8+ T cells and the cytokines they produce are crucial for protection against tuberculosis they have different roles in tuberculosis immunology. The function of CD4+ T cells has been extensively studied; however, less is known about the phenotype and function of CD8+ T cells. This study evaluated the specific expression of IFN-γ, IL-17, IL-10, and TGF-β and ex vivo expression of perforin and granzyme-B by CD8+ T cells from active tuberculosis individuals compared with latent infected individuals and non-latent infected individuals. Tuberculosis responses were correlated with the baciloscopy score. We observed that the presence of IL-10 and TGF-β expression and down-expression of granzyme-B in CD8+ T cells correlated with increased sputum bacillary load in active tuberculosis individuals. These findings provide new insights into the role of CD8+ T cells in Mycobacterium tuberculosis disease.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Silva BDS,Trentini MM,da Costa AC,Kipnis A,Junqueira-Kipnis APdoi
10.1016/j.imlet.2014.03.009subject
Has Abstractpub_date
2014-07-01 00:00:00pages
23-32issue
1eissn
0165-2478issn
1879-0542pii
S0165-2478(14)00055-8journal_volume
160pub_type
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pub_type: 杂志文章
doi:10.1016/j.imlet.2005.08.005
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journal_title:Immunology letters
pub_type: 杂志文章
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2008.01.010
更新日期:2008-05-15 00:00:00
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更新日期:2018-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0165-2478(82)90069-4
更新日期:1982-01-01 00:00:00
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pub_type: 信件
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更新日期:2009-09-22 00:00:00
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doi:10.1016/s0165-2478(00)00177-2
更新日期:2000-05-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2013-11-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2002-05-01 00:00:00
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pub_type: 杂志文章
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