Abstract：
:A CD8+ cytotoxic T-cell clone that recognized HIV p24gag was isolated from an infected individual. The minimal epitope was localized to amino acids 308-316 (QASQEVKNW). Using allogeneic target cells, we found that lysis was restricted by the HLA-Cw0401 molecule. We observed that C1R cells, that express the HLA-Cw0401 allele are able to present the peptide to the cytotoxic clone, but with reduced efficiency. Other B-cell lines, that have been genotyped as HLA-Cw0401+ were unable to present the peptide to the clone, suggesting the existence of other variants of HLA-Cw0401 or a loss of cell surface expression of this molecule.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Buseyne F,Stevanovic S,Rammensee HG,Rivière Ydoi
10.1016/s0165-2478(97)02696-5subject
Has Abstractpub_date
1997-03-01 00:00:00pages
145-9issue
3eissn
0165-2478issn
1879-0542pii
S0165-2478(97)02696-5journal_volume
55pub_type
杂志文章abstract：:Homogeneous IgG fractions were obtained by chromatography of the sera of patients with multiple sclerosis (MS) on Protein G-Sepharose under conditions that remove non-specifically bound proteins. These IgGs contained several chelated metals, the relative amount of which decreases in the order: Fe>or=Ca>Cu>or=Zn>or=Mg>...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.10.018
更新日期：2006-02-28 00:00:00
abstract：:Potential endogenous ligands for the cysteine rich domain of the murine mannose receptor (MR) have been detected in marginal zone metallophilic macrophages in spleen and subcapsular sinus macrophages in lymph nodes of naive mice by immunohistochemistry using a Fc chimeric protein. Additional labelling was observed in ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00117-5
更新日期：1999-01-01 00:00:00
abstract：:Atopic dermatitis (AD) and allergic contact dermatitis (ACD) are common skin inflammatory conditions. B and T cells are strongly implicated in allergic contact hypersensitivity (CHS) conditions. Activation of IgD B-cell receptor (BCR) by anti-IgD stimulation depletes mature B cells and modulates T-helper cell type 1/2...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2018.09.008
更新日期：2018-11-01 00:00:00
abstract：:Interleukin-21 (IL-21) is a T cell-derived cytokine modulating T cell, B cell, and natural killer cell responses. To determine whether IL-21 contributes to pathologic processes, recombinant IL-21 receptor (R) fusion protein (rhIL-21R-Fc) was examined in mice models of autoimmune arthritis (collagen-induced arthritis)....
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.09.007
更新日期：2015-02-01 00:00:00
abstract：:In human tumors of neuroectodermal origin cell surface expression of individual gangliosides is either increased or decreased relative to comparable normal cells. We have previously shown that gangliosides shed from melanoma cells can immunomodulate T cell activity. Monocytes/macrophages (m/m) are known to play an imp...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(89)90034-5
更新日期：1989-03-01 00:00:00
abstract：:As a cytokine adjuvant, granulocyte-macrophage colony-stimulating factor (GM-CSF) has been demonstrated to play central roles in the enhancement of the immune response and protection elicited by experimental vaccines. However, in our previous work, the co-administration of GM-CSF produced untoward effects on the immun...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.08.005
更新日期：2014-11-01 00:00:00
abstract：:Transforming growth factor-beta (TGF-beta) is usually known as an immunosuppressive cytokine, but we and others have shown stimulatory effects of TGF-beta on activation of Th2 T-lymphocytes. In the present investigation we have studied the effect of TGF-beta1 on phosphorylation of ERK, a MAP-kinase downstream of the R...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00184-x
更新日期：2000-06-01 00:00:00
abstract：:A quantitative approach was applied to the study of in vivo expression of foreign genes introduced into mice by ballistic transfection. Because in some cases one must take into account both the level of synthesized protein and that of antibodies to it, we derived the equation which allows to calculate the exact quanti...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00269-8
更新日期：2000-11-01 00:00:00
abstract：BACKGROUND:Takayasu's arteritis (TA) is a chronic inflammation that affects the large vessels; however, its etiology is still unknown. Human serum paraoxonase hydrolyzes oxidized lipids into low-density lipoproteins and could therefore be associated with the prevalence of inflammation processes. Therefore, the purpose ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2013.04.005
更新日期：2013-04-01 00:00:00
abstract：:Wistar rats submitted to 3 intravenous (i.v.) or intraperitoneal (i.p.) immunizations with saline extract of rat male accessory glands (RAG) associated to liposomes developed a delayed type hypersensitivity (DTH) response to RAG after the first immunization, a remission state after the second immunization and a specif...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90125-t
更新日期：1991-04-01 00:00:00
abstract：:Several recent studies have shown that the antigen receptors (mIgM and mIgD) on normal B cell surfaces are part of larger multimolecular complexes, as each is noncovalently coupled to at least two other proteins whose phosphorylation is inducible upon G protein activation. However, B cell receptor complexes appear to ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(92)90050-x
更新日期：1992-05-01 00:00:00
abstract：:In a previous study we have shown that, in response to electrical stimulation, there is a substantial release of noradrenaline (NA) from the sympathetic nerve terminals of the rat thymus which is of axonal, vesicular origin. In the present study neurochemical evidence was obtained that the release of NA is subject to ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(95)00085-j
更新日期：1995-07-01 00:00:00
abstract：:Cross-linking of BCR rapidly induces protection of B cells from Fas-mediated apoptosis, which has been assumed one of the important survival mechanisms of B cells during antigen stimulation. In the mouse B cell line A20, which is sensitive to Fas-mediated apoptosis, stimulation of BCR inhibited apoptosis induced via F...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2006.12.009
更新日期：2007-03-15 00:00:00
abstract：:In early seventies "natural killer (NK) cells", a third lymphocyte subset was discovered that revealed an unexpected ability to kill syngeneic and allogeneic tumor targets, thus emerging as the most potent non-specific cytotoxic cells in both human and mouse. Decades of research revealed the multifaceted nature of the...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2013.12.009
更新日期：2014-10-01 00:00:00
abstract：:We determined the degree of activation of the TNF alpha system and the levels of IL-8 in HIV-1 infection. TNF alpha is one of the most potent agents for the induction of IL-8. TNF alpha may be cleared rapidly from the circulation, however soluble tumor necrosis factor receptor (sTNFR) p75 which is more stable may refl...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(96)02583-7
更新日期：1996-08-01 00:00:00
abstract：:It remains unclear whether lipopolysaccharide (LPS) pre-treatment, which prevents Th2-type responses via Toll-like receptor 4 (TLR4), inhibits anaphylaxis. To determine the dose-dependent effects of LPS pre-treatment on anaphylactic decreases in rectal temperature caused by ovalbumin (OVA) re-exposure in immunized mic...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2008.03.001
更新日期：2008-06-15 00:00:00
abstract：:Flt3 ligand, a recently described growth factor affecting early hematopoietic progenitor cells, can also support the expansion of dendritic cells secreting IL-12. Its potential use in a clinical setting has been suggested. Here, we studied the effect of in situ delivery of Flt3 ligand plasmid (FL) on the antibody resp...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(02)00039-1
更新日期：2002-05-01 00:00:00
abstract：:Interleukin-18 (IL-18) plays a central role in the immune response by acting on Th1 cell differentiation, cell-mediated cytotoxicity and inflammation. The role of IL-18 in cancers and inflammatory diseases is discussed in the light of our investigations on IL-18 synthesis in normal colonic mucosa, colonic cancer and C...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/s0165-2478(00)00285-6
更新日期：2000-12-01 00:00:00
abstract：:In the H-2-incompatible donor-recipient combination (BALB/c----CBA/H) local administration of cyclosporin allows a 4-fold reduction in a single dose prolonging survival of heart tissue allografts. These results suggest that local administration of cyclosporin may be useful for certain grafts. ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90067-z
更新日期：1990-02-01 00:00:00
abstract：:Two types of inhibition of basic peptide-induced rat mast cell secretion are reported. Pretreatment of rat peritoneal mast cells with Vibrio comma neuraminidase, an enzyme which cleaves sialic acid from oligosaccharides, led to inhibition of 5-hydroxytryptamine release induced by the basic peptides polylysine, cortico...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90134-1
更新日期：1982-10-01 00:00:00
abstract：:Zipper-interacting protein kinase (ZIPK) is a widely expressed serine/threonine kinase that has been implicated in cell death and transcriptional regulation, but its mechanism of regulation remains unknown. Here, we identified threonine-265 (Thr265) in ZIPK as a major autophosphorylation site. Mutational analyses reve...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.10.015
更新日期：2006-03-15 00:00:00
abstract：OBJECTIVE:Behçet's disease (BD) is a chronic multi-factorial inflammatory disease with the important role of genetic in activation of its inflammatory response. Interleukin (IL)-33 is a member of the IL-1 family of cytokines that affects innate and adaptive immune systems to promote inflammatory responses. In the curre...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2018.11.005
更新日期：2019-08-01 00:00:00
abstract：:Drosophila has recently become a powerful model organism for studies of innate immunity. The cellular elements of innate immunity in Drosophila, the hemocytes, have been characterized by morphological criteria, molecular markers, and cell-type-specific immunological markers. Here we suggest that an MiET1 GFP-reporter ...
journal_title：Immunology letters
pub_type： 信件
doi：10.1016/j.imlet.2009.08.004
更新日期：2009-09-22 00:00:00
abstract：:Direct interaction between Fusobacterium nucleatum and human neutrophils resulted in the secretion of a neutrophil self-regulatory factor(s). The secretion of this factor was bacteria specific, and depended on the integrity of the bacteria cell surface. Factor secretion occurred within 15 min of bacteria--neutrophil i...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90086-1
更新日期：1987-01-01 00:00:00
abstract：:Galectin-1 (Gal-1) has been implicated in tumor progression partly via the induction of T-cell apoptosis. However the mechanism of Gal-1 induced T-cell death was mostly studied using recombinant, soluble Gal-1 producing controversial results. To explore the true mechanism of Gal-1 and hence tumor cell-induced T-cell d...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.10.003
更新日期：2010-01-04 00:00:00
abstract：:We have utilized a limiting dilution assay, involving a minimum of in vitro culture, to determine the frequencies of CD4+ T cells which have the capacity to secrete IL-2 (Th1), IL-4 (Th2) or IL-2 and IL-4 (Th0). CD4+ lymph node cells obtained from unimmunized mice were found to contain 40% Th1, 34% Th2, and 26% Th0 ce...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90197-x
更新日期：1990-01-01 00:00:00
abstract：:HLA-specific antibodies generated by allo-immunization are supposed to be involved in the control of HIV infections by both the neutralizing capacity of HLA-specific antibodies (Abs) and HLA-specific Ab-dependent complement-mediated lysis (CML). We further characterized CML of HIV primary isolates induced by HLA-speci...
journal_title：Immunology letters
pub_type： 信件
doi：10.1016/j.imlet.2009.08.005
更新日期：2009-09-22 00:00:00
abstract：:Cysticercosis caused by Taenia solium is a very common disease in developing countries that seriously affects human health. Diagnosis can only be confirmed with the aid of computerized tomography or nuclear magnetic resonance (NMR) creating obvious difficulties for epidemiological studies. Reliable immunoassays employ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(99)00166-2
更新日期：2000-01-10 00:00:00
abstract：:Isolation of recombinant antibodies from antibody libraries is commonly performed by different molecular display formats including phage display and ribosome display or different cell-surface display formats. We describe a new method which allows the selection of Escherichia coli cells producing the required single ch...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2013.02.005
更新日期：2013-03-01 00:00:00
abstract：:In the present study, short tandem repeats (STR) polymorphism within the first intron of IFN-gamma gene in connection with HLA-DRB1*03 specificities was analysed in 43 sarcoidosis patients, 14 of which presented with Löfgren's syndrome (LS). Four out of 5 known IFN-gamma alleles with 12-15 CA repeats, respectively wer...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2003.11.005
更新日期：2004-02-15 00:00:00
