Phosphorylation of threonine-265 in Zipper-interacting protein kinase plays an important role in its activity and is induced by IL-6 family cytokines.


:Zipper-interacting protein kinase (ZIPK) is a widely expressed serine/threonine kinase that has been implicated in cell death and transcriptional regulation, but its mechanism of regulation remains unknown. Here, we identified threonine-265 (Thr265) in ZIPK as a major autophosphorylation site. Mutational analyses revealed that autophosphorylation of Thr265 were essential for its full catalytic activity toward an exogenous substrate as well as for cell death induction. Furthermore, leukemia inhibitory factor (LIF) stimulated Thr265 phosphorylation of ZIPK, thereby leading to phosphorylation and activation of signal transducer and activator of transcription (STAT3). Taken together, our findings demonstrate that ZIPK is positively regulated through Thr265 phosphorylation and that this phosphorylation is essential for its function.


Immunol Lett


Immunology letters


Sato N,Kamada N,Muromoto R,Kawai T,Sugiyama K,Watanabe T,Imoto S,Sekine Y,Ohbayashi N,Ishida M,Akira S,Matsuda T




Has Abstract


2006-03-15 00:00:00














  • Apoptosis and oxidative burst in neutrophils infected with Mycobacterium spp.

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: González-Cortés C,Reyes-Ruvalcaba D,Diez-Tascón C,Rivero-Lezcano OM

    更新日期:2009-09-22 00:00:00

  • CD4 Th1 but not Th2 clones efficiently activate macrophages to eliminate Trypanosoma cruzi through a nitric oxide dependent mechanism.

    abstract::We have recently generated CD4 clones from BALB/c mice immunized with a plasmid DNA containing the gene encoding for the catalytic domain of trans-sialidase, an important enzyme expressed on the surface of Trypanosoma cruzi trypomastigotes. These clones allowed us to study in vitro the interaction between T cells and ...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Rodrigues MM,Ribeirão M,Boscardin SB

    更新日期:2000-07-03 00:00:00

  • Phospholipase D enzymes facilitate IL-17- and TNFα-induced expression of proinflammatory genes in rheumatoid arthritis synovial fibroblasts (RASF).

    abstract::In rheumatoid arthritis, the synovium exhibits fibroblast hyperplasia and dynamic infiltration of activated T cells. Interaction between rheumatoid arthritis synovial fibroblasts (RASF) and T cell subsets such as Th17 cells can stimulate RASF to express IL-6, IL-8, CCL20, and other proinflammatory mediators of joint d...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Friday SC,Fox DA

    更新日期:2016-06-01 00:00:00

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    abstract::MHC tetramers are used to directly enumerate and visualize the antigen-specific T lymphocyte population of interest by flow cytometry, regardless of the T lymphocyte's functional capacity. Assay sensitivity can be hindered by non-specific binding activity, which is due to the inherent interactions of CD8 and MHC. Poin...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Nugent CT,Renteria RO,Kuus-Reichel K,Kumar A

    更新日期:2005-05-15 00:00:00

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Jimenez SA,Rosenbloom J

    更新日期:1985-01-01 00:00:00

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Bianco TM,Abdalla DR,Desidério CS,Thys S,Simoens C,Bogers JP,Murta EFC,Michelin MA

    更新日期:2017-10-01 00:00:00

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Hojo H,Kaneko A,Nanya K,Kayagaki N,Hashimoto Y

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  • Isotype profiles of anti-gp160 antibodies from HIV-infected patients in plasma and culture supernatants.

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Béniguel L,Bégaud E,Peruchon S,Cognasse F,Gabrié P,Marovich M,Lucht F,Genin C,Garraud O

    更新日期:2004-04-30 00:00:00

  • Chloroquine: modes of action of an undervalued drug.

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    journal_title:Immunology letters

    pub_type: 杂志文章,评审


    authors: Thomé R,Lopes SC,Costa FT,Verinaud L

    更新日期:2013-06-01 00:00:00

  • Down-regulation of murine B lymphocyte growth: arrest of B cells in G1 underlies immunosuppression induced by an IgM antibody.

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Uher F,Mihalik R,Alonso ME,Gergely J

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Buseyne F,Stevanovic S,Rammensee HG,Rivière Y

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    journal_title:Immunology letters

    pub_type: 临床试验,杂志文章


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    更新日期:2019-09-01 00:00:00

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Kanbour A,Macpherson TA,Kunz HW,Gill TJ 3rd

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    journal_title:Immunology letters

    pub_type: 杂志文章,评审


    authors: Sikaria S,Aldoss I,Akhtari M

    更新日期:2016-04-01 00:00:00

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    journal_title:Immunology letters

    pub_type: 杂志文章


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    journal_title:Immunology letters

    pub_type: 信件


    authors: Honti V,Kurucz E,Csordás G,Laurinyecz B,Márkus R,Andó I

    更新日期:2009-09-22 00:00:00

  • Rescue of the mature B cell compartment in BAFF-deficient mice by treatment with recombinant Fc-BAFF.

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Swee LK,Tardivel A,Schneider P,Rolink A

    更新日期:2010-06-15 00:00:00

  • Cellular responses of guinea-pig macrophages to C4a; inhibition of C3a-induced O2- generation by C4a.

    abstract::We have investigated the cellular responses of guinea-pig macrophages to human C4a. C4a induced a biphasic Ca2+ mobilization; a rapid temporary Ca2+ mobilization from intracellular Ca2+ pool followed by a weak Ca2+ influx of extracellular Ca2+. Although the C4a-treated macrophages did not respond again to C4a, that is...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Murakami Y,Yamamoto T,Imamichi T,Nagasawa S

    更新日期:1993-06-01 00:00:00

  • New B-cell CD molecules.

    abstract::B cells not only play a pivotal role in humoral immunity, but also are involved in a broad spectrum of immune responses, including antigen presentation and T-cell function regulation. The identification of cell-surface CD molecules derived from a series of Human Leukocyte Differentiation Antigens (HLDA) Workshops has ...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Matesanz-Isabel J,Sintes J,Llinàs L,de Salort J,Lázaro A,Engel P

    更新日期:2011-01-30 00:00:00

  • C3d-mediated negative and positive signals on the proliferation of human B cells separated from blood.

    abstract::Soluble C3d applied to human blood-derived B lymphocytes inhibited anti-mu, T cell-produced growth factor, and EBV-induced DNA synthesis in serum-free culture. C3d added to the B cell cultures 1 and 2 days after the stimulus, still exerted inhibition, though with gradually diminishing efficiency. C3d, fixed on zymosan...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Kuraya M,Nilsson B,Nilsson-Ekdahl K,Klein E

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  • A specific type of membrane microdomains is involved in the maintenance and translocation of kinase active Lck to lipid rafts.

    abstract::Lck is the principal signal-generating tyrosine kinase of the T cell activation mechanism. We have previously demonstrated that induced Lck activation outside of lipid rafts (LR) results in the rapid translocation of a fraction of Lck to LR. While this translocation predicates the subsequent production of IL-2, the me...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Ballek O,Broučková A,Manning J,Filipp D

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Janelidze S,Enell K,Visse E,Darabi A,Salford LG,Siesjö P

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  • A novel prophylaxis with C1-inhibitor concentrate in hereditary angioedema during erythema marginatum.

    abstract:BACKGROUND:Hereditary angioedema with C1-inhibitor deficiency (C1-INH-HAE) is a rare, autosomal dominant disorder. The characteristic episodes of subcutaneous/submucosal edema formation may be preceded by erythema marginatum (EM) - the occurrence of a 'map-like' pattern on the skin. EM can occur as an isolated finding ...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Kőhalmi KV,Veszeli N,Cervenak L,Varga L,Farkas H

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  • Inherited deficiencies of complement components in man.

    abstract::Isolated inherited deficiency states of almost every complement protein have been recognized. Almost all are autosomal recessive traits. Deficiency of the early-acting components C1, C4 and C2 is associated with increased risk of immune complex disease, particularly systemic lupus erythematosus. Patients with deficien...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Alper CA

    更新日期:1987-02-01 00:00:00

  • Intramuscular co-injection of naked DNA encoding HBV core antigen and Flt3 ligand suppresses anti-HBc antibody response.

    abstract::Flt3 ligand, a recently described growth factor affecting early hematopoietic progenitor cells, can also support the expansion of dendritic cells secreting IL-12. Its potential use in a clinical setting has been suggested. Here, we studied the effect of in situ delivery of Flt3 ligand plasmid (FL) on the antibody resp...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Kwon TK,Park JW

    更新日期:2002-05-01 00:00:00

  • Light-chain profiles in sera from patients with subacute sclerosing panencephalitis.

    abstract::Sera from 2 subacute sclerosing panencephalitis (SSPE) patients were absorbed with a concentrated preparation of measles virus. Measles-specific IgG was eluted from the precipitates containing measles antigen-antibody complex. These IgGs, when subjected to immunofixation after isoelectric focusing showed a number of o...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Mehta PD,Thormar H

    更新日期:1982-02-01 00:00:00

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Garraud O,Daculsi R,Merlio JP,Lobera A,Legrand E

    更新日期:1987-05-01 00:00:00

  • Genetic regulation of macrophage priming/activation: the Lsh gene story.

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    journal_title:Immunology letters

    pub_type: 杂志文章,评审


    authors: Blackwell JM,Roach TI,Atkinson SE,Ajioka JW,Barton CH,Shaw MA

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  • Local pulmonary immune stimulation by the Toll-like receptor 2 and 6 ligand MALP-2 in rats is age dependent.

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Lührmann A,Grote K,Stephan M,Tschernig T,Pabst R

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    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Choremi-Papadopoulou E,Faure GC,Malenica B,Misbah SA,Zlabinger GJ

    更新日期:2009-06-30 00:00:00