当前位置： SCI文献检索 > IMMUNOLOGY LETTERS期刊下所有文献 > Nicotine alters the biological activities of developing mouse bone marrow-derived dendritic cells (DCs).

Nicotine alters the biological activities of developing mouse bone marrow-derived dendritic cells (DCs).

Abstract：

:Cigarette smoke contains nicotine, an immunomodulatory component that is thought to affect immune surveillance and increase the progression of diseases. Dendritic cells (DCs) constitute a family of antigen-presenting (APCs) with inherent abilities to sense and translate environmental cues and to shape host immunity. We recently reported on the effects of nicotine on human DCs and proposed a possible mechanism that links cigarette smoke to higher incidences of respiratory tract infection and asthma. To establish the causal relationship between nicotine-induced DC alterations and immunomodulation in vivo, we translated our in vitro human results to the mouse system and studied the direct effects of nicotine exposure on the biological and functional properties of mouse bone marrow (BM) DCs differentiated in vitro from their precursors. We report that while the presence of nicotine in the microenvironment has no direct effect on competent mouse BM-derived DCs function, it promotes the development of mouse BM DC precursors into DCs (thereafter called nicDCs) with a semi-mature phenotype revealed by higher expression of costimulatory molecules CD80, CD86, CD40, MHC II molecules and the lymph node homing receptor, CCR7. Consistent with their maturational status, these nicDCs have reduced capacity for antigen uptake and produce substantially less Th1-promoting cytokine, IL-12, in response to Th1-polarizing adjuvant, lipopolysaccharide (LPS). Interestingly, we found that nicDCs preferentially support the proliferation and differentiation of ovalbumin (OVA)-specific naïve T cells into effector memory cells, producing significantly less IFN-gamma and more IL-4. These results provide evidence for the similarity in the effects of nicotine on mouse and human DCs, particularly the ability to modulate DC differentiation towards developing Th2 immunity.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Nouri-Shirazi M,Tinajero R,Guinet E

doi

10.1016/j.imlet.2007.02.005

subject

Has Abstract

pub_date

2007-04-15 00:00:00

pages

155-64

issue

2

eissn

0165-2478

issn

1879-0542

pii

S0165-2478(07)00034-X

journal_volume

109

pub_type

杂志文章

相关文献

IMMUNOLOGY LETTERS文献大全
  • A novel prophylaxis with C1-inhibitor concentrate in hereditary angioedema during erythema marginatum.

    abstract：BACKGROUND:Hereditary angioedema with C1-inhibitor deficiency (C1-INH-HAE) is a rare, autosomal dominant disorder. The characteristic episodes of subcutaneous/submucosal edema formation may be preceded by erythema marginatum (EM) - the occurrence of a 'map-like' pattern on the skin. EM can occur as an isolated finding ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2017.05.015

    authors： Kőhalmi KV,Veszeli N,Cervenak L,Varga L,Farkas H

    更新日期：2017-09-01 00:00:00

  • Dispensable role for 4-1BB and 4-1BBL in development of vaccinia virus-specific CD8 T cells.

    abstract：:CD8 T cells are strongly induced in response to certain strains of vaccinia virus (VACV) and the generation of this population is tightly regulated by two Tumor Necrosis Factor (TNF)/TNFR superfamily members, OX40 (CD134) and CD27. In this study, we examined the role of another member of the TNFR superfamily, 4-1BB (C...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2011.10.008

    authors： Zhao Y,Croft M

    更新日期：2012-01-30 00:00:00

  • Graft-versus-host disease in murine bone marrow transplantation. I. Modification of GVHD by preimmunization of recipients with spleen cells of primary recipients undergoing GVHD.

    abstract：:Lethally irradiated (1000 rad) CBA/J mice were transplanted with anti-Thy 1 treated BALB/c bone marrow. Under these conditions, we uniformly observed the development of pathology suggestive of acute graft-vs.-host disease (GVHD), i.e. weight loss, diarrhoea, hypogammaglobulinemia and thymic hypoplasia. If, 2 wk before...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(85)90109-9

    authors： Gorczynski RM,Kennedy M,Robillard M

    更新日期：1985-01-01 00:00:00

  • Soluble ST2 and IL-33: Potential markers of endometriosis in the Tunisian population.

    abstract：:Interleukin-33 is an IL-1 family cytokine which signals via its T1/ST2 receptor, and acts as a key regulator of inflammation. This study aims to measure the expression of soluble ST2 (sST2) and IL-33 in endometriosis. We investigated thirty women with laparoscopic and histopathological confirmed endometriosis and 20 c...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2015.05.002

    authors： Mbarik M,Kaabachi W,Henidi B,Sassi FH,Hamzaoui K

    更新日期：2015-07-01 00:00:00

  • Monocyte derived IL 10 and PGE2 are associated with the absence of Th 1 cells and in vitro T cell suppression in lepromatous leprosy.

    abstract：:Our previous studies had shown that the clinicopathological spectrum in leprosy was associated with discrete T cell subsets in circulation, with tuberculoid patients having antigen-induced Th 1, whereas lepromatous leprosy patients with antigen-specific T cell anergy possessed Th 2 cells. The present study shows that ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(95)02455-7

    authors： Misra N,Selvakumar M,Singh S,Bharadwaj M,Ramesh V,Misra RS,Nath I

    更新日期：1995-12-01 00:00:00

  • Peptide motif of a cattle MHC class I molecule.

    abstract：:A consensus motif for a bovine major histocompatibility complex (MHC) class I molecule, A20, was derived from parainfluenza type-3 (PI-3) virus-infected muscle-derived fibroblast cells and peripheral blood leukocytes by extraction of the naturally processed peptides from MHC class I molecules by treatment with TFA and...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(94)00244-l

    authors： Bamford AI,Douglas A,Friede T,Stevanovic S,Rammensee HG,Adair BM

    更新日期：1995-02-01 00:00:00

  • The diversity of T-cell receptor repertoire of peripheral CD4+ lymphocytes in LEC mutant rats.

    abstract：:A novel mutant strain of rats, LEC, exhibits an arrest of T-cell maturation from CD4+CD8+ to CD4+CD8- but not the CD4-CD8+ cells in the thymus. Nevertheless, CD4+T cells arise in lymph nodes of LEC rats, implying extrathymic T-cell maturation. We analyzed the variable (V) and junctional region diversity of T-cell rece...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(94)00254-o

    authors： Muramatsu Y,Agui T,Sakai T,Yamada T,Matsumoto K

    更新日期：1995-03-01 00:00:00

  • Lymphocyte subsets are influenced by positivity levels in healthy subjects before and after mild acute stress.

    abstract：:In the current study, the possible association of positivity (POS), recently defined as general disposition to view life under positive outlook, with immune markers and post-stress modifications, was analyzed. Circulating lymphocyte subsets and serum cytokine levels were evaluated before and after a standard mild acut...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2017.05.012

    authors： Caprara GV,Nisini R,Castellani V,Vittorio P,Alessandri G,Vincenzo Z,Claudia F,Valentina G,Andrea PD,Biondo MI,Milanetti F,Salerno G,Vincenzo V,Mario P,Aniballi E,Simonetta S,Angela S,D'Amelio R

    更新日期：2017-08-01 00:00:00

  • Humoral immune response directed against LEDGF in patients with VKH.

    abstract：:Vogt-Koyanagi-Harada disease is an autoimmune systemic disorder. In Vogt-Koyanagi-Harada disease, inflammatory disorders occur in multiple organs containing melanocytes, including uvea (resulting in acute bilateral panuveitis), skin (resulting in vitiligo and alopecia), central nervous system (resulting in meningitis)...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(01)00243-7

    authors： Yamada K,Senju S,Shinohara T,Nakatsura T,Murata Y,Ishihara M,Nakamura S,Ohno S,Negi A,Nishimura Y

    更新日期：2001-10-01 00:00:00

  • Isotype of antibodies responsible for immune lysis in Trypanosoma cruzi infected mice.

    abstract：:Serum obtained from mice infected with Trypanosoma cruzi have antibodies able to induce immune lysis in presence of complement. Gel filtration in Sephadex G-200 and affinity chromatography with rabbit anti-mouse IgG and protein A-Sepharose showed that the antibodies responsible for the immune serum lytic activity are ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(83)90040-8

    authors： Stefani MM,Takehara HA,Mota I

    更新日期：1983-01-01 00:00:00

  • Multiple effects of human recombinant interleukin 4 on human myeloid monocyte cell lines.

    abstract：:The effects of recombinant human interleukin 4 (rIL-4) on proliferation and differentiation on human myeloid/monocytic leukemia cell lines were examined. At high concentrations, rIL-4 had a slight enhancing effect on [3H]thymidine incorporation by U937 cells. rIL-4 markedly induced expression of the Fc epsilon recepto...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(89)90027-8

    authors： Noma T,Nakakubo H,Hama K,Honjo T

    更新日期：1989-06-15 00:00:00

  • Probing molecular changes induced in DNA by reactive oxygen species with monoclonal antibodies.

    abstract：:Antibodies reactive with native double stranded DNA are characteristic of the chronic inflammatory disease systemic lupus erythematosus. Native DNA is however, a poor immunogen and the mechanism of anti-DNA antibody production is incompletely understood. Modification of DNA can increase its immunogenicity and in infla...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(92)90237-i

    authors： Blount S,Griffiths HR,Staines NA,Lunec J

    更新日期：1992-10-01 00:00:00

  • Attenuation of the Fas-L independent B16BL6 melanoma lymphocidic capacity by H-2K class I molecules.

    abstract：:We have previously reported that the capacity of highly malignant B16BL6 murine melanoma cells to induce cell death in naive syngeneic lymphocytes stems from the absence of major histocompatibility complex (MHC) class I glycoproteins in these melanoma cells. Our present study provides evidence that the above-mentioned...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2005.03.016

    authors： Kellman-Pressman S,Fishman D,Tsory S,Segal S

    更新日期：2005-09-15 00:00:00

  • Characterization of factor H-related cell membrane molecules expressed by human B lymphocytes and neutrophil granulocytes.

    abstract：:The human factor H protein family comprises six plasma glycoproteins. Earlier we described a membranal factor H-related (mFHR) molecule that is expressed by human B lymphoblastoid cell lines and exerts cofactor activity. In our present study we screened human blood cells for the presence of mFHR proteins and further c...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(01)00194-8

    authors： Józsi M,Kapus A,Kerekes K,Kármán J,Bajtay Z,Zipfel PF,Erdei A

    更新日期：2001-05-01 00:00:00

  • Reduced expression of granule proteins during extended survival of eosinophils in splenocyte culture with GM-CSF.

    abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multifaceted hematopoietic cytokine and the culture of mouse bone marrow with GM-CSF produces a variety of myeloid cells including granulocytes, macrophages, and dendritic cells. In the present study, we cultured mouse splenocytes with GM-CSF and examined ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2016.03.003

    authors： Ryu SH,Na HY,Sohn M,Han SM,Choi W,In H,Hong S,Jeon H,Seo JY,Ahn J,Park CG

    更新日期：2016-05-01 00:00:00

  • Control of mouse graft-versus-host disease following allogeneic bone marrow transplantation by blocking the CD28/B7 signaling pathway with lentiviral vector-mediated RNA interference.

    abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective way to cure hematological malignancies. However, graft-versus-host disease (GVHD) following transplantation limits the clinical application to some extent. The donor T lymphocytes play a central role in the occurrence and development of GVH...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2011.01.010

    authors： Sang W,Zhou C,Cheng N,Li Z,Zeng L,Xu K

    更新日期：2011-05-01 00:00:00

  • Modulation of C3 gene expression in HepG2 human hepatoma cells.

    abstract：:Inflammation elicits an acute phase response, which includes changes in plasma concentrations of a number of cytokines, reflecting changes in their gene transcription in the liver. In this study, the induction of complement factor 3 (C3) was investigated in HepG2 cells, a human hepatoma cell line often used as a model...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(01)00180-8

    authors： Wright MS,Sund NJ,Abrahamsen TG

    更新日期：2001-03-01 00:00:00

  • Immune reactivity during COVID-19: Implications for treatment.

    abstract：:Clinical symptoms of COVID-19 include fever, cough, and fatigue which may progress to acute respiratory distress syndrome (ARDS). The main hematological laboratory findings associated with the severe form of disease are represented by lymphopenia and eosinopenia which mostly occur in the elderly population characteriz...

    journal_title：Immunology letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.imlet.2021.01.001

    authors： Napoli C,Benincasa G,Criscuolo C,Faenza M,Liberato C,Rusciano M

    更新日期：2021-01-06 00:00:00

  • Interaction between serum amyloid A and leukocytes - a possible role in the progression of vascular complications in diabetes.

    abstract：:Diabetes mellitus is associated with an increased incidence of cardiovascular events and microvascular complications. Serum amyloid A (SAA), a HDL apolipoprotein is a risk marker for cardiovascular disease. A permanent increase in SAA plasma levels is observed in diabetics. Because SAA acts on leukocytes, we evaluated...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2006.12.005

    authors： Hatanaka E,Monteagudo PT,Marrocos MS,Campa A

    更新日期：2007-02-15 00:00:00

  • Heparin and platelet interactions influence alloantigen-induced proliferative responses of human T lymphocytes and immunoglobulin synthesis in vivo.

    abstract：:In contrast to defibrinated blood, cells isolated from heparinized blood give lower T-lymphoproliferative responses. Such responses can be also suppressed by addition of heparin to lymphocyte cultures. Platelets inhibit T cell proliferation and B cell differentiation, but their interactions with heparin may produce co...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(91)90115-q

    authors： Górski A,Wasik M,Stepień-Sopniewska B,Glapiński T

    更新日期：1991-05-01 00:00:00

  • Identification of the polymorphisms in IFITM1 gene and their association in a Korean population with ulcerative colitis.

    abstract：:Interferon inducible transmembrane protein (IFITM) family genes have been implicated in several cellular processes such as the homotypic cell adhesion functions of IFNs and cellular anti-proliferative activities. We previously showed that the IFITM3 single nucleotide polymorphisms (SNPs) associated with susceptibility...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2013.09.026

    authors： Mo JS,Na KS,Yu JI,Chae SC

    更新日期：2013-11-01 00:00:00

  • Long-term omalizumab efficacy in allergic rhinitis.

    abstract：BACKGROUND:Omalizumab therapy was found to be safe and effective as an add-on therapy for patients with poorly controlled severe asthma. Although several studies over the last decade have demonstrated its efficacy in other Immunoglobulin E related diseases, its use in such conditions is off-label. OBJECTIVE:This study...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2020.08.002

    authors： Cavaliere C,Begvarfaj E,Incorvaia C,Sposato B,Brunori M,Ciofalo A,Greco A,de Vincentiis M,Masieri S

    更新日期：2020-11-01 00:00:00

  • Cross-linking HLA-DR molecules on Th1 cells induces anergy in association with increased level of cyclin-dependent kinase inhibitor p27(Kip1).

    abstract：:HLA class II molecules play pivotal roles in antigen presentation to CD4+ T cells. We investigated signaling via HLA-DR molecules expressed on CD4+ T cells. When HLA-DR or CD3 molecules on cloned CD4+ T cells were cross-linked by solid-phase mAbs, T cells proliferated, and this resulted in anergy. Whereas cross-linkin...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(01)00341-8

    authors： Kudo H,Matsuoka T,Mitsuya H,Nishimura Y,Matsushita S

    更新日期：2002-04-22 00:00:00

  • Abrogation of tumor induced Ly49 expression on mouse spleen cells by mitomycin C.

    abstract：:Mouse spleen cells were activated with IL2 for 4 days in the presence or absence of paraformaldehyde fixed YAC (PFY) tumor cells (spleen cell: PFY ratio 100:1). Fresh spleen cells had poor expression of Ly49A but the expression was significantly upregulated by IL2 activation. Addition of PFYs resulted in a further boo...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(01)00206-1

    authors： Das A,Saxena RK

    更新日期：2001-06-01 00:00:00

  • A novel monoclonal antibody recognizing human thymocytes and B-cell chronic lymphocytic leukemia cells.

    abstract：:This paper describes a new murine monoclonal antibody, UN5, raised against human thymocytes. This antibody recognizes a molecule of approximately 45 kDa on thymocytes. Flow cytometric analysis reveals a high intensity of labeling with the majority of thymocytes, whereas only CD20+ cells from peripheral whole-blood sam...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(94)90098-1

    authors： Tassone P,Bonelli P,Tuccillo F,Bond HM,Turco MC,Morrone G,Cecco L,Cerra M,Venuta S

    更新日期：1994-02-01 00:00:00

  • Disparity in the percentage of CD4+ T lymphocytes and prognosis of HIV-infected intravenous drug users in Malaysia.

    abstract：:The CD4+ T-lymphocyte absolute count (CD4ac), CD4+ T-lymphocyte percentage (CD4%) and total lymphocyte count (Løac) were assessed in HIV-seropositive intravenous drug users (IVDU) with reference to their correlation with the clinical categories A, B, and C as stipulated by the Centre of Disease Control and Prevention,...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(94)90219-4

    authors： Norazmi MN,Suarn S

    更新日期：1994-12-01 00:00:00

  • The involvement of multifunctional TGF-β and related cytokines in pathogenesis of endometriosis.

    abstract：PURPOSE:Transforming growth factor β (TGF-β) is one of the major immune and inflammation factors responsible for regulating cell proliferation, differentiation, angiogenesis, and immune responses. Deregulated TGF-β activity, especially its influence in peritoneal cytokine cross-talk, has been implicated in pathologies ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2018.10.011

    authors： Sikora J,Smycz-Kubańska M,Mielczarek-Palacz A,Bednarek I,Kondera-Anasz Z

    更新日期：2018-09-01 00:00:00

  • Unravelling novel functions of the endosomal transporter mannose 6-phosphate/insulin-like growth factor receptor (CD222) in health and disease: An emerging regulator of the immune system.

    abstract：:Properly balanced cellular responses require both the mutual interactions of soluble factors with cell surface receptors and the crosstalk of intracellular molecules. In particular, immune cells exposed unceasingly to an array of positive and negative stimuli must distinguish between what has to be tolerated and attac...

    journal_title：Immunology letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.imlet.2017.08.011

    authors： Leksa V,Ilková A,Vičíková K,Stockinger H

    更新日期：2017-10-01 00:00:00

  • Presentation of the Plasmodium falciparum antigen Pf155/RESA to human T cells. Variations in responsiveness induced by antigen presenting cells from different but MHC class II identical donors.

    abstract：:The antibody response in humans naturally primed to a malaria vaccine candidate antigen (Pf155/RESA) is genetically regulated. Here, the impact of antigen presenting cells (APC) on the control of in vitro T-cell responses induced by Pf155/RESA or synthetic peptides corresponding to its major Pf155/RESA epitopes was st...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(94)00163-4

    authors： Troye-Blomberg M,Lepers JP,Sjöberg K,Rahalimalala L,Larsson A,Olerup O,Perlmann P

    更新日期：1994-12-01 00:00:00

  • Targeting PPAR ligands as possible approaches for metabolic reprogramming of T cells in cancer immunotherapy.

    abstract：:Despite the prominent progress in understanding cancer immunosurveillance mechanisms, there are some types of problems which have been identified to hinder effective and successful immunotherapy of cancers. Such problems have been ascribed to the tumor abilities in the creation of a tolerant milieu that can impair imm...

    journal_title：Immunology letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.imlet.2020.01.006

    authors： Bahrambeigi S,Molaparast M,Sohrabi F,Seifi L,Faraji A,Fani S,Shafiei-Irannejad V

    更新日期：2020-04-01 00:00:00