Abstract:
:A consensus motif for a bovine major histocompatibility complex (MHC) class I molecule, A20, was derived from parainfluenza type-3 (PI-3) virus-infected muscle-derived fibroblast cells and peripheral blood leukocytes by extraction of the naturally processed peptides from MHC class I molecules by treatment with TFA and peptide sequencing of the complex mixture. The results showed that the majority of peptides were 9 amino acids long with position 2 occupied by lysine and position 9 occupied by arginine. The arginine at position 9 suggests that cattle, like humans, but unlike the mouse have permissive TAP transporter molecules accepting peptides with positively charged amino acids at their C-terminus. This is the first report of a MHC ligand motif in cattle.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Bamford AI,Douglas A,Friede T,Stevanovic S,Rammensee HG,Adair BMdoi
10.1016/0165-2478(94)00244-lsubject
Has Abstractpub_date
1995-02-01 00:00:00pages
129-36issue
1-2eissn
0165-2478issn
1879-0542pii
0165-2478(94)00244-Ljournal_volume
45pub_type
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