Cytochrome P450 1A1 and manganese superoxide dismutase genes polymorphisms in ankylosing spondylitis.

abstract：:While the cytoskeletal protein talin binds to the β-chain of LFA-1, the immune cell adaptor SKAP1 (SKAP-55) binds to the α-chain of the same integrin via RapL. Whereas calpain protease cleavage of talin is important for LFA-1 activation, it has been unclear whether SKAP1 can alter the function of talin or its associat...

journal_title：Immunology letters

authors： Lim D,Lu Y,Rudd CE

更新日期：2016-04-01 00:00:00

abstract：UNLABELLED:To study the pathogenic importance of the rheumatoid factor (RF) in rheumatoid arthritis (RA) and to identify genes differentially expressed in patients and healthy individuals, total RNA was isolated from peripheral blood mononuclear cells (PBMC) from eight RF-positive and six RF-negative RA patients, and s...

journal_title：Immunology letters

authors： Bovin LF,Rieneck K,Workman C,Nielsen H,Sørensen SF,Skjødt H,Florescu A,Brunak S,Bendtzen K

更新日期：2004-05-15 00:00:00

abstract：:A CD8+ cytotoxic T-cell clone that recognized HIV p24gag was isolated from an infected individual. The minimal epitope was localized to amino acids 308-316 (QASQEVKNW). Using allogeneic target cells, we found that lysis was restricted by the HLA-Cw0401 molecule. We observed that C1R cells, that express the HLA-Cw0401 ...

journal_title：Immunology letters

authors： Buseyne F,Stevanovic S,Rammensee HG,Rivière Y

更新日期：1997-03-01 00:00:00

abstract：:Administration of opioids that bind to the classical mu opioid receptor has been shown to lead to unintended alterations in immune function. Traditionally, altered immune function has been investigated with circulating immune cells. Effects of mu agonists on intestinal epithelial immune function have not been describe...

journal_title：Immunology letters

authors： Neudeck BL,Loeb JM

更新日期：2002-12-03 00:00:00

abstract：:The aim of the present letter is to propose a rational nomenclature for the d-mannose-binding lectin from seeds of Artocarpus integrifolia. It is justified by the existing confusion in the literature concerning the trivial names used until now to designate the lectin and by the increasing interest in its biomedical ap...

journal_title：Immunology letters

authors： Pereira-da-Silva G,Roque-Barreira MC,Van Damme EJ

更新日期：2008-08-15 00:00:00

abstract：:Thymocyte development requires an integration of extracellular cues to enforce lineage commitment at multiple defined checkpoints in a stage-specific manner. Critical signals from the pre-TCR, Notch, and the receptor for interleukin-7 (IL-7) dictate cellular differentiation from the CD4(-)CD8(-) (double negative) stag...

journal_title：Immunology letters

authors： Juntilla MM,Koretzky GA

更新日期：2008-03-15 00:00:00

abstract：:The effects of recombinant human interleukin 4 (rIL-4) on proliferation and differentiation on human myeloid/monocytic leukemia cell lines were examined. At high concentrations, rIL-4 had a slight enhancing effect on [3H]thymidine incorporation by U937 cells. rIL-4 markedly induced expression of the Fc epsilon recepto...

journal_title：Immunology letters

authors： Noma T,Nakakubo H,Hama K,Honjo T

更新日期：1989-06-15 00:00:00

abstract：:Human natural killer (NK) cell activity was not significantly affected by leukotriene (LT) B4 over a wide concentration range (10(-6)-10(-14) M), whether added directly to the NK cell assay or after preincubation of effector cells for 2 h with the drug before addition of Cr labelled K562 target cells. In addition, LTB...

journal_title：Immunology letters

authors： Hall TJ,Brostoff J

更新日期：1985-01-01 00:00:00

abstract：:Dendritic cells (DC) can direct downstream T-cell responses. Although bacterial adjuvants are strong activators of DC in vitro, the effects of normal enteric bacteria on DC in vivo are not well defined. We used germ-free (GF) mice to determine whether enteric bacteria alter DC phenotype and ability to stimulate naïve ...

journal_title：Immunology letters

authors： Walton KL,He J,Kelsall BL,Sartor RB,Fisher NC

更新日期：2006-01-15 00:00:00

abstract：:In murine models, challenge with different viral and parasitic infection is closely associated with the production of type I interferons (IFN-alpha/beta) and NK cell production of interferon-gamma (IFN-gamma). Therefore, we wished to determine if IFN-alpha/beta had a role in the regulation of NK cell production of IFN...

journal_title：Immunology letters

authors： Hunter CA,Gabriel KE,Radzanowski T,Neyer LE,Remington JS

更新日期：1997-10-01 00:00:00

abstract：:Regulated upon activation normal T expressed and secreted (RANTES) is a new inducible protein member of the human C-C branch of chemokines. RANTES is a potent monocyte and lymphocyte chemoattractant and is a mediator of inflammatory responses. In these studies we found that RANTES 10 ng/50 microl chemoattracts basophi...

journal_title：Immunology letters

authors： Conti P,Reale M,Barbacane RC,Frydas S,Felaco M,Grilli A,Placido FC,Cataldo I,Feliciani C,Di Gioacchino M,Anogianakis G,Dimitriadou D,Vacalis D,Trakatellis A

更新日期：1997-07-01 00:00:00

abstract：:N-Acetyl-l-cysteine (NAC) is a well-known medication, primarily used as a mucolytic agent in pulmonary disease. Recently, we have found that NAC possesses antipyretic properties. The aim of the present study was to investigate the mechanism by which NAC attenuates fever. The concentration of interleukin (IL)-10 and pr...

journal_title：Immunology letters

authors： Wrotek S,Jędrzejewski T,Piotrowski J,Kozak W

更新日期：2016-09-01 00:00:00

abstract：:The binding of anti-IgM IgG to human monoclonal IgM has been studied calorimetrically and results have been compared with parallel turbidity measurements of the same reaction. In the first series of experiments using the flow calorimeter equipped with a mixing cell, varied flow rates gave identical values for the ther...

journal_title：Immunology letters

authors： Rialdi G,Raffanti S

更新日期：1984-01-01 00:00:00

abstract：:Both, HIV envelope proteins gp120 and gp41 can directly activate complement system, even in the absence of HIV-specific antibodies. During the budding process HIV acquires host membrane-associated molecules among these complement regulatory proteins (CRPs). The presence of CRPs on the viral surface rescues HIV from co...

journal_title：Immunology letters

authors： Bánki Z,Stoiber H,Dierich MP

更新日期：2005-03-15 00:00:00

abstract：:In early seventies "natural killer (NK) cells", a third lymphocyte subset was discovered that revealed an unexpected ability to kill syngeneic and allogeneic tumor targets, thus emerging as the most potent non-specific cytotoxic cells in both human and mouse. Decades of research revealed the multifaceted nature of the...

journal_title：Immunology letters

authors： Bellora F,Castriconi R,Dondero A,Carrega P,Mantovani A,Ferlazzo G,Moretta A,Bottino C

更新日期：2014-10-01 00:00:00

abstract：:Alpha-fetoprotein (AFP), an onco-fetal protein which binds specifically polyunsaturated fatty acids, has been shown to modulate arachidonic acid metabolism in a human T-cell line. In Jurkat lymphoma cells, AFP decreases the synthesis of prostaglandins and increases the release of arachidonic acid and leukotrienes. The...

journal_title：Immunology letters

authors： Aussel C,Fehlmann M

更新日期：1987-01-01 00:00:00

abstract：:Using embryonic chickens treated with testosterone propionate, the effects of congenital absence of the bursa of Fabricius determined by the frequency of J chain-positive cells was examined in the spleen, thymus and bone marrow at the embryonic and newly hatched stages. J chain-positive cells in the chicks without bur...

journal_title：Immunology letters

authors： Moriya O,Ichikawa Y

更新日期：1984-01-01 00:00:00

abstract：:Part of pathogen-associated molecular pattern (PAMP) and damage-associated molecular pattern (DAMP) activate antigen-presenting cells through Toll-like receptors (TLRs) to initiate immune responses. However, controversy remains if TLR4 mediates DAMP signaling due to the confounding effects of potential LPS contaminati...

journal_title：Immunology letters

authors： Lee KM,Seong SY

更新日期：2009-06-30 00:00:00

abstract：:We aimed to investigate if angiopoietin-2 (Ang-2) participates in the septic process and what may be the role of monocytes as a site of release of Ang-2 in sepsis. Concentrations of Ang-2 were estimated in sera and in supernatants of monocytes derived form one already described cohort of 90 patients with septic syndro...

journal_title：Immunology letters

authors： Kranidioti H,Orfanos SE,Vaki I,Kotanidou A,Raftogiannis M,Dimopoulou I,Kotsaki A,Savva A,Papapetropoulos A,Armaganidis A,Giamarellos-Bourboulis EJ

更新日期：2009-06-30 00:00:00

abstract：:Hepatitis B virus (HBV)-specific cytotoxic T lymphocytes (CTLs) are thought to play key roles in viral control and liver damage. We have used HLA-A*02 tetramer complex to human HBV core 18-27 (Tc 18-27), envelope 183-191 (Te 183-191), envelope 335-343 (Te 335-343), and polymerase 575-583 (Tp 575-583) epitopes to chara...

journal_title：Immunology letters

authors： Wu Y,Zhang J,Chen S,Chen A,Wang L,Li J,Zhao T,Zou L,Tang Y,Tingrong L,Wang F

更新日期：2004-04-15 00:00:00

abstract：:A broad array of biological responses including cell polarization, movement, immune and inflammatory responses, as well as prevention of HIV-1 infection, are triggered by the chemokines, a family of secreted and structurally related chemoattractant proteins that bind to class A-specific seven-transmembrane receptors l...

journal_title：Immunology letters

authors： Muñoz LM,Holgado BL,Martínez-A C,Rodríguez-Frade JM,Mellado M

更新日期：2012-07-30 00:00:00

abstract：:The leukocyte common antigen, CD45, is one of the major glycoproteins on cells of hemopoietic origin showing considerable heterogeneity in both structure and expression. Biochemical heterogeneity has been attributed to differences in the primary sequence and glycosylation. In this paper we report an additional basis f...

journal_title：Immunology letters

authors： Oravecz T,Monostori E,Adrian O,Kurucz E,Andó I

更新日期：1994-04-01 00:00:00

abstract：:The role of the immune system in the defense against cancer, a process termed tumor immunosurveillance, has been extensively studied. Evidence is accumulating that the molecular organization of proteins and lipids in the plasma membrane of immune cells is of critical importance. Tetraspanin proteins are expressed in t...

journal_title：Immunology letters

authors： Veenbergen S,van Spriel AB

更新日期：2011-08-30 00:00:00

abstract：:It remains unclear whether lipopolysaccharide (LPS) pre-treatment, which prevents Th2-type responses via Toll-like receptor 4 (TLR4), inhibits anaphylaxis. To determine the dose-dependent effects of LPS pre-treatment on anaphylactic decreases in rectal temperature caused by ovalbumin (OVA) re-exposure in immunized mic...

journal_title：Immunology letters

authors： Shiva D,Matsumoto T,Kremenik MJ,Kato Y,Yano H

更新日期：2008-06-15 00:00:00

abstract：:Inflammatory bowel disease (IBD) is caused by chronic inflammation of the gastrointestinal tract. The pathogenesis of IBD remains unclear. The inflammation is associated with activation of T helper (Th) lymphocytes and chronic production of inflammatory cytokines. Ro60 suppresses the expression of tumor necrosis facto...

journal_title：Immunology letters

authors： Kim SY,Park MJ,Kwon JE,Choi SY,Seo HB,Jung KA,Choi JW,Baek JA,Lee HH,Lee BI,Park SH,Cho ML

更新日期：2018-09-01 00:00:00

abstract：:The first step in the clearance of apoptotic cells is chemotactic migration of macrophages towards the apoptotic cells guided by find-me signals provided by the dying cells. Upon sensing the chemotactic signals, macrophages release ATP. ATP is then degraded to ADP, AMP and adenosine to trigger purinergic receptors con...

journal_title：Immunology letters

authors： Joós G,Jákim J,Kiss B,Szamosi R,Papp T,Felszeghy S,Sághy T,Nagy G,Szondy Z

更新日期：2017-03-01 00:00:00

abstract：:MHC tetramers are used to directly enumerate and visualize the antigen-specific T lymphocyte population of interest by flow cytometry, regardless of the T lymphocyte's functional capacity. Assay sensitivity can be hindered by non-specific binding activity, which is due to the inherent interactions of CD8 and MHC. Poin...

journal_title：Immunology letters

authors： Nugent CT,Renteria RO,Kuus-Reichel K,Kumar A

更新日期：2005-05-15 00:00:00

abstract：:The question is still unresolved whether in insulin-dependent (type I) diabetes T-lymphocytes mediate an autoimmune response towards pancreatic islets. We now present direct evidence in an animal model for autoimmune T-lymphocytes with specificity for islet antigens. Mice of strain C57BL/6 were immunized repeatedly wi...

journal_title：Immunology letters

authors： Kolb H,Ben-Nun A,Cohen IR,Barberena I,Kiesel U

更新日期：1985-01-01 00:00:00

abstract：:Mimotopes derived from peptide phage display libraries may reproduce basic functions of epitopes including their antigenicity. In case of toxins, this property makes phage displayed mimotopes highly specific vaccine components free of the toxicity. To explore the potential of mimotopes for vaccine development, their a...

journal_title：Immunology letters

authors： Hernández R,Gazarian TG,Hérion PS,Gazarian KG

更新日期：2002-02-01 00:00:00

abstract：:The spontaneous migration in vitro, production of T cell migration inhibitory factor (TIF) and the response to TIF of OKT4+ and OKT8+ human T cell subsets were studied. The OKT4+ lymphocytes migrated far better than the OKT8+ cells although the movement of both subsets was comparably inhibited by TIF. The OKT8+ subset...

journal_title：Immunology letters

authors： Kowalczyk D,Pryjma J,Zembala M

更新日期：1986-08-01 00:00:00