Abstract：
:The binding of anti-IgM IgG to human monoclonal IgM has been studied calorimetrically and results have been compared with parallel turbidity measurements of the same reaction. In the first series of experiments using the flow calorimeter equipped with a mixing cell, varied flow rates gave identical values for the thermic contribution, indicating that the same quantity of heat was evolved in the different time intervals in which the reaction mixture was in the calorimetric cell. In the second set of experiments a flow-through cell was used. Reactants were mixed outside the calorimeter and no heat was detected upon entry of the pre-mixed reactants into the calorimetric cell. Results suggest that heat is evolved instantaneously upon mixing and no heat is produced during aggregation. Antibody-antigen binding can be followed in the absence of precipitation, as may occur in reactions involving monoclonal antibodies.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Rialdi G,Raffanti Sdoi
10.1016/0165-2478(84)90091-9subject
Has Abstractpub_date
1984-01-01 00:00:00pages
335-8issue
6eissn
0165-2478issn
1879-0542pii
0165-2478(84)90091-9journal_volume
7pub_type
杂志文章abstract：UNLABELLED:To study the pathogenic importance of the rheumatoid factor (RF) in rheumatoid arthritis (RA) and to identify genes differentially expressed in patients and healthy individuals, total RNA was isolated from peripheral blood mononuclear cells (PBMC) from eight RF-positive and six RF-negative RA patients, and s...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.03.018
更新日期：2004-05-15 00:00:00
abstract：:Based on the fact that monoclonal antibody (mAb) 2F5 recognizing ELDKWA-epitope on HIV-1 gp41 separately or in combination with other mAbs showed potent neutralizing activity to a wide range of primary HIV-1 isolates in vivo and in vitro, but this epitope undergoes restricted mutation. ELNKWA is a neutralizing-resista...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00298-4
更新日期：2001-01-01 00:00:00
abstract：:Members of the transforming growth factor beta (TGF-beta) superfamily are soluble factors that regulate a variety of functional responses including proliferation, differentiation, apoptosis and cell cycle, among others, depending not only on the cell type and its differentiation state, but also on the milieu of cytoki...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2006.12.010
更新日期：2007-03-15 00:00:00
abstract：:This report describes an immunoradiometric assay for Plasmodium falciparum in infected blood, based on a cross-reacting monoclonal antibody (mAb) raised against P. berghei. In this assay, binding of the mAb to intact P. berghei parasites coated on microtiter plates is inhibited by solubilized P. falciparum infected re...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90046-x
更新日期：1985-01-01 00:00:00
abstract：:IgE-mediated activation of basophil granulocytes and mast cells follows a bell-shaped dose-response curve. The decreased activation at supraoptimal allergen stimulation is thought to be associated with SH2-containing inositol-5'-phosphatase 1 (SHIP-1). SHIP-1 phosphorylation is inversely related to IgE-mediated releas...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2019.04.003
更新日期：2019-06-01 00:00:00
abstract：:Drosophila has recently become a powerful model organism for studies of innate immunity. The cellular elements of innate immunity in Drosophila, the hemocytes, have been characterized by morphological criteria, molecular markers, and cell-type-specific immunological markers. Here we suggest that an MiET1 GFP-reporter ...
journal_title：Immunology letters
pub_type： 信件
doi：10.1016/j.imlet.2009.08.004
更新日期：2009-09-22 00:00:00
abstract：:The leukocyte common antigen, CD45, is one of the major glycoproteins on cells of hemopoietic origin showing considerable heterogeneity in both structure and expression. Biochemical heterogeneity has been attributed to differences in the primary sequence and glycosylation. In this paper we report an additional basis f...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90198-8
更新日期：1994-04-01 00:00:00
abstract：:HLA-specific antibodies generated by allo-immunization are supposed to be involved in the control of HIV infections by both the neutralizing capacity of HLA-specific antibodies (Abs) and HLA-specific Ab-dependent complement-mediated lysis (CML). We further characterized CML of HIV primary isolates induced by HLA-speci...
journal_title：Immunology letters
pub_type： 信件
doi：10.1016/j.imlet.2009.08.005
更新日期：2009-09-22 00:00:00
abstract：:Within the 3' end of nucleotide sequence of human adult T-cell leukaemia virus (ATLV) four small open frames in various phases were found previously. The frames code for 10,000-, 11,000-, 12,000- and 27,000-dalton polypeptides, one of which can be responsible for virus transforming activity. By means of methods of pre...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90093-9
更新日期：1987-01-01 00:00:00
abstract：:Although there is growing evidence that NKT cells play an important role in various immune responses through the invariant T cell receptor, other cell surface molecules responsible for their function are not fully understood. Here we study the role of ICOS, the third member of the CD28 family of costimulatory receptor...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.11.002
更新日期：2010-01-18 00:00:00
abstract：:An automated biosensor system designed for measuring molecular interactions in real time and without any labelling of the reactants has been used to study the interaction of two animal viruses (vaccinia virus and poliovirus) and two plant viruses (cowpea mosaic virus and tobacco mosaic virus) with monoclonal antibodie...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(92)90011-c
更新日期：1992-01-01 00:00:00
abstract：:Properly balanced cellular responses require both the mutual interactions of soluble factors with cell surface receptors and the crosstalk of intracellular molecules. In particular, immune cells exposed unceasingly to an array of positive and negative stimuli must distinguish between what has to be tolerated and attac...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2017.08.011
更新日期：2017-10-01 00:00:00
abstract：:Lyophilized bacterial lysates, which actively stimulate the immune response, are widely used as vaccines or 'biological response modifiers' in subjects with recurrent bacterial respiratory infections. Since vaccines are indicated in the absence or in the presence of a weak constitutive immune response activity, a bett...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(02)00290-0
更新日期：2003-03-03 00:00:00
abstract：:Even though IgA is considered to play an important role in immunity, surprisingly little is known about the presence of IgA Fc receptor (Fc alpha R)-expressing effector cells in tissues. Difficulties in obtaining human tissue macrophages, led us to study peritoneal macrophages in a human Fc alpha RI transgenic (Tg) mo...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(99)00034-6
更新日期：1999-05-03 00:00:00
abstract：:This paper describes functional and genetic studies on the macrophage resistance gene Lsh/Ity/Bcg first described almost two decades ago. Working in vitro with resident peritoneal, liver (Kupffer cells) and bone marrow derived macrophages from congenic B10 (LshS) and B10.L-LshR mice it has been possible to demonstrate...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/0165-2478(91)90032-6
更新日期：1991-10-01 00:00:00
abstract：UNLABELLED:Helicobacter pylori infection in humans causes gastritis. The infection elicits a complex immune response in which the activation of mast cells and histamine release is of particular importance. Histamine further promotes the immune response and stimulates gastric acid secretion. The inflammatory effects of ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.05.005
更新日期：2004-07-15 00:00:00
abstract：:The purpose of this study is to show that anti-Leu M1 antibody (anti-CD15), which has different staining characteristics in lymphoid and non-lymphoid cells, reacted against the surface antigen of a defined monoclonal B cell line. This antibody recognizes the sugar moiety, lacto-N-fucopentaose (LNF-III), which is linke...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(89)90153-3
更新日期：1989-11-01 00:00:00
abstract：:Lymphocytes obtained from thymus and spleens of 1-6 week old White Leghorn cockerels, untreated or immunized twice with sheep red blood cells (SRBC), were cultured with common T-cell mitogens in serial dilutions and/or different concentrations of bovine prolactin (PRL). [3H]Thymidine incorporation in newly synthesized...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90044-q
更新日期：1990-06-01 00:00:00
abstract：:An autoreactive T lymphocyte clone, designated as F1C4 was established from an autoimmune mouse strain (NZB/NZW)F1. This clone proliferated in the presence of mitomycin C-treated splenic adherent cells (MMC-SAC) from syngeneic mice. This response was dependent on the numbers of MMC-SAC. The specificity of F1C4 for I-A...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(88)90175-7
更新日期：1988-08-01 00:00:00
abstract：:This article has been withdrawn at the request of the authors and Guest Editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.09.015
更新日期：2009-10-04 00:00:00
abstract：:CD8+CD28- regulatory T cells (Tregs) play important roles in chronic viral infections. Programmed death 1 (PD-1) is highly expressed on hepatitis C virus (HCV)-specific CTLs. However, little is known regarding the role of CD8+CD28-PD1+ T cells in hepatitis C. Herein, we found that the frequency of CD8+CD28-PD1+, but n...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2018.07.008
更新日期：2018-10-01 00:00:00
abstract：:The attenuated androgen Danazol can partially reverse the biochemical defect and prevent angioedema in patients with inherited C1-inhibitor (C1-INH) deficiency (hereditary angioedema, HAE). Though its clinical effectiveness is independent from significant increase of C1-INH plasma levels, its mechanism of action remai...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(03)00029-4
更新日期：2003-05-01 00:00:00
abstract：:Monoclonal antibodies (mAb) reacting with native (TA5, TB12) and denatured (T33, T35) plant toxin mistletoe lectin I (MLI) from Viscum album have been obtained. The interaction between mAbs and native toxin with ML isoforms (MLII, MLIII) has been investigated. An immunological cross-reaction has been shown to take pla...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)00181-p
更新日期：1995-01-01 00:00:00
abstract：:The earliest T-cell precursor population in the adult mouse thymus (low CD4 precursors) may be divided into 85% of cells expressing surface Mel-14 (LECAM-1, the lymphocyte homing receptor) and 15% of cells which are Mel-14. To date, this is the only surface marker for which we have found this population to be heteroge...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90177-5
更新日期：1994-05-01 00:00:00
abstract：:Our previous studies had shown that the clinicopathological spectrum in leprosy was associated with discrete T cell subsets in circulation, with tuberculoid patients having antigen-induced Th 1, whereas lepromatous leprosy patients with antigen-specific T cell anergy possessed Th 2 cells. The present study shows that ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(95)02455-7
更新日期：1995-12-01 00:00:00
abstract：:Adult T-cell leukemia-derived factor (ADF)/human thioredoxin (TRX) has thiol-dependent reducing activities and is known to have regulatory roles on the DNA-protein interaction and cell activation. Inducive effect of ultraviolet (UV) has been indicated because of the enhanced expression of ADF/TRX in epidermal cells of...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(95)00213-o
更新日期：1995-01-01 00:00:00
abstract：:Interleukin-21 (IL-21) is a T cell-derived cytokine modulating T cell, B cell, and natural killer cell responses. To determine whether IL-21 contributes to pathologic processes, recombinant IL-21 receptor (R) fusion protein (rhIL-21R-Fc) was examined in mice models of autoimmune arthritis (collagen-induced arthritis)....
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.09.007
更新日期：2015-02-01 00:00:00
abstract：:Over the last two decades HIV-1 has spread worldwide and has now surpassed malaria as the leading cause of infectious disease mortality in adults (http://www.who.int/infectious-disease-report/pages/ch1text.html). The clinical course and outcome of HIV-1 infection are highly variable among individuals. Most individuals...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/s0165-2478(01)00275-9
更新日期：2001-11-01 00:00:00
abstract：:Multiple sclerosis (MS) is a debilitating neurological disorder of the central nervous system (CNS), characterized by activation and infiltration of leukocytes and dendritic cells into the CNS. In the initial phase of MS and its animal model, experimental autoimmune encephalomyelitis (EAE), peripheral macrophages infi...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2014.03.006
更新日期：2014-07-01 00:00:00
abstract：:DC are unique antigen presenting cells, and their ability to induce proliferation of T cells in a mixed leukocyte reaction (MLR) assay is commonly used for the evaluation of their function. To determine the mechanisms involved in DC-induced T cell activation in a primary MLR assay, a variety of different agents were e...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(01)00235-8
更新日期：2001-09-03 00:00:00
