Abstract:
:Lymphocytes obtained from thymus and spleens of 1-6 week old White Leghorn cockerels, untreated or immunized twice with sheep red blood cells (SRBC), were cultured with common T-cell mitogens in serial dilutions and/or different concentrations of bovine prolactin (PRL). [3H]Thymidine incorporation in newly synthesized DNA was used as a measure of lymphocyte mitogenic stimulation. Lymphocytes were stimulated by mitogens, as well as by PRL alone, in a dose-dependent way. Cell cultures prepared from immunized and non-immunized donors differed in their response to mitogens or PRL. The present results demonstrate direct PRL action on avian lymphoid cells and resemble those found in the mammalian immune system.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Skwarło-Sońta Kdoi
10.1016/0165-2478(90)90044-qsubject
Has Abstractpub_date
1990-06-01 00:00:00pages
171-7issue
3eissn
0165-2478issn
1879-0542pii
0165-2478(90)90044-Qjournal_volume
24pub_type
杂志文章abstract::In transgenic mice over-expressing CD200 (CD200(tg)) graft survival is associated with increased intra-graft expression of mRNAs for genes associated with altered T cell subset differentiation (Foxp3; TGFβ; IL-10). Grafts are rejected in recipients lacking the inhibitory receptor for CD200, CD200R1. We compared grafts...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2012.11.004
更新日期:2013-01-01 00:00:00
abstract::Serum IgG1 levels are selectively increased in patients with chronic hepatitis C virus (HCV) infection. In 15 patients who received interferon (IFN)-alpha therapy, serum levels of immunoglobulin classes and IgG subclasses were measured during treatment and after it was discontinued. In spite of important individual va...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(96)02681-8
更新日期:1997-01-01 00:00:00
abstract::Cells engulf particles larger than 0.5 μm in diameter by phagocytosis, which is driven by cytoskeletal rearrangements. Phagocytosis by alveolar epithelial cells (AECs) helps to maintain the alveolar homeostasis. Yes-associated protein (YAP), a transcriptional coactivator of the Hippo pathway, affects proliferation, di...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2020.06.009
更新日期:2020-09-01 00:00:00
abstract::After exposure to a concanavalin A (Con A)-unreactive variant of alpha 1-acid glycoprotein (AGP), macrophages released an inhibitor of interleukin-1 (IL-1) proliferative activity in the thymocyte comitogenic assay. This effect was observed with AGP concentrations above 100 micrograms/ml in the macrophage supernatant a...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90184-r
更新日期:1990-10-01 00:00:00
abstract::We examined the alphabeta T cell receptor (TCR) repertoire of naturally occurring CD4+CD25+ regulatory T (Treg) cells isolated from healthy human blood. Three-color FACS analysis demonstrated that the usage of variable region segments of TCRbeta chains by CD4+CD25+ cells did not differ from those of CD4+CD25- cells. C...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2005.02.011
更新日期:2005-07-15 00:00:00
abstract::Transforming growth factor-beta (TGF-beta) is usually known as an immunosuppressive cytokine, but we and others have shown stimulatory effects of TGF-beta on activation of Th2 T-lymphocytes. In the present investigation we have studied the effect of TGF-beta1 on phosphorylation of ERK, a MAP-kinase downstream of the R...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(00)00184-x
更新日期:2000-06-01 00:00:00
abstract::Dendritic cells (DCs) are very important for the generation of long lasting immune responses against pathogens or the induction of anti-tumor responses. Targeting antigen to dendritic cells via monoclonal antibodies specific for DC cell surface receptors such as DEC205 was shown to elicit potent cellular and humoral i...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2010.06.002
更新日期:2010-08-16 00:00:00
abstract::We have previously reported the production of a series of human monoclonal antibodies reacting with mouse mammary tumor viral antigens as well as the human counterpart HuMTV antigen. Against two of these antibodies (B11 and 4.6/6), anti-idiotypic antibodies were generated, which appeared to be the internal image of vi...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90128-w
更新日期:1991-04-01 00:00:00
abstract::Clinical immunology is in the Netherlands a separate clinical specialty within internal medicine and pediatrics. Clinical immunologists work closely together with nephrologists, rheumatologists and many other medical specialists. Apart from research and teaching, clinical immunologists are taking care of patients with...
journal_title:Immunology letters
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.imlet.2014.10.008
更新日期:2014-12-01 00:00:00
abstract::Incorporation of [3h]thymidine ([3H]TdR) into concanavalin A (Con A)-stimulated murine splenocytes was found to be enhanced by addition of certain concentrations of ethanol, 2-propanol and acetone. The alcohol/acetone-induced enhancement of the Con A response was found to be accompanied by an increase of the percentag...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(82)90057-8
更新日期:1982-06-01 00:00:00
abstract::Lethally irradiated (1000 rad) CBA/J mice were transplanted with anti-Thy 1 treated BALB/c bone marrow. Under these conditions, we uniformly observed the development of pathology suggestive of acute graft-vs.-host disease (GVHD), i.e. weight loss, diarrhoea, hypogammaglobulinemia and thymic hypoplasia. If, 2 wk before...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(85)90109-9
更新日期:1985-01-01 00:00:00
abstract::The effects of interferon-alpha (IFN-alpha), INF-gamma, transforming growth factor beta (TGF-beta) and dexamethasone on low-affinity Fc receptors for IgE (Fc epsilon R2/CD23) expression on a human eosinophilic leukemia cell line, Eol-3, were examined. Fc epsilon R2/CD23 expression was enhanced by both IFN-alpha and IF...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90201-z
更新日期:1990-09-01 00:00:00
abstract::Experiments with malaria in mice suggest that protective immunity depends not only on antibody but also on activation of macrophages. Activated macrophages may cause intra-erythrocytic death of parasites by releasing reactive oxygen intermediates and/or tumour necrosis factor. Macrophage activation for both types of p...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/0165-2478(85)90173-7
更新日期:1985-01-01 00:00:00
abstract::Several studies have implicated a role for the cell surface glycoprotein CD44 in lymphocyte differentiation, adhesion to the matrix, homing, activation and apoptosis. However, the requirement of CD44 in B cell maturation remains elusive. To address this point, we analyzed the generation and activation of B lymphocytes...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.06.004
更新日期:2004-08-15 00:00:00
abstract::The regulatory effect of Z-100 on the balance of Th1/Th2 cell responses in BALB/c mice bearing Meth-A fibrosarcoma was investigated. In tumor bearing mice, Th1 cytokine production (IL-2, IFN-gamma) are suppressed and Th2 cytokine production (IL-4, IL-10) are increased, as compared with those of normal mice. The admini...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(99)00130-3
更新日期:1999-11-01 00:00:00
abstract::To investigate the in vivo role of complement component C5 it is common to compare the inflammatory response between C5-normal and C5-deficient inbred mice strains. Nevertheless, it should be expected that differences in the genetic backgrounds between those strains may affect several physiological parameters, complic...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.02.010
更新日期:2014-05-01 00:00:00
abstract::We have studied the mechanisms involved in the activation or suppression of the immune response by the tumor cells, which is also dependent on the site of tumor transplantation. AK-5 tumor cells when transplanted s.c. activated peritoneal macrophages through the induction of different cytokines, whereas tumor cells wh...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(02)00034-2
更新日期:2002-07-03 00:00:00
abstract::The immunomodulatory and antiviral effects of an extracellular polysaccharide (EPS-2), produced by a strain of Geobacillus thermodenitrificans isolated from a shallow marine vent of Vulcano Island (Italy), were evaluated. In the present study, we show for the first time that EPS-2 treatment hinder HSV-2 replication in...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.03.001
更新日期:2009-04-27 00:00:00
abstract::Dendritic cells (DCs) are highly specialized antigen-presenting cells that play a key role in the initiation and regulation of immune responses. The ability of DCs to process antigens and the outcome of their interaction with T cells are largely dependent on phenotype as well as maturation state of DCs. In this study,...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2005.05.012
更新日期:2005-11-15 00:00:00
abstract::This paper describes functional and genetic studies on the macrophage resistance gene Lsh/Ity/Bcg first described almost two decades ago. Working in vitro with resident peritoneal, liver (Kupffer cells) and bone marrow derived macrophages from congenic B10 (LshS) and B10.L-LshR mice it has been possible to demonstrate...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/0165-2478(91)90032-6
更新日期:1991-10-01 00:00:00
abstract::In spite of impressive results in the treatment of acute lymphoblastic B cell leukemia (B-ALL) with chimeric antigen receptor (CAR) T cells, the clinical outcome of some hematological cancers like follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL) has not been very promising likely due to immunosuppressiv...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2020.04.005
更新日期:2020-07-01 00:00:00
abstract::The tryptophan fluorescence properties of two different peptide complexes of the single-chain H-2Kd (SC-Kd) were studied by means of the single-photon counting technique. The latter enables time-resolved measurements of fluorescence intensity and anisotropy decay parameters relevant to structural and dynamic propertie...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90183-x
更新日期:1994-05-01 00:00:00
abstract::As one studies more and more the immune systems of invertebrates their multiplicity and diversity increase. On one hand, the number of different local and systemic innate mechanisms (or cascades of mechanisms) increases with every phylum studied, on the other hand the diversity increases within each system as multiple...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2003.10.012
更新日期:2004-03-29 00:00:00
abstract::A new method of panning for B lymphocytes is described in which the ability of the sIg+ cells to adhere depends on the nature and concentration of nonspecific protein used rather than on the use of anti-immunoglobulin. Rat lymph node cells were suspended in 3% bovine serum albumin in Tris-buffered Hanks' and incubated...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90130-1
更新日期:1987-08-01 00:00:00
abstract::Clone C19 derived from a rat bladder cancer cell line BC31ad constitutively released cytotoxic factor RCF. The serum-free C19-conditioned medium was partially purified by DEAE-Sephacel, Sephacryl S-200 and MonoQ-FPLC chromatographies to the specific activity of 6.4 x 10(6) U/mg protein (LM assay). RCF was a 17-kDa pro...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90051-5
更新日期:1994-06-01 00:00:00
abstract::Nervous and immune systems share specific recognition molecules for signals that originate in both systems. The information substances are polypeptides and their receptors. They comprise the multi-directional information exchange network whereby brain and nervous system function including mood and emotion can be integ...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/0165-2478(87)90171-4
更新日期:1987-12-01 00:00:00
abstract::Cell surface molecules are present on several lymphocyte subsets and are differentially expressed during lymphocyte development and activation. Human Leukocyte Differentiation Antigen (HLDA) Workshops have played an essential role in the identification and characterization of the molecules found in the membrane of hem...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2010.10.009
更新日期:2011-01-30 00:00:00
abstract::Interferon inducible transmembrane protein (IFITM) family genes have been implicated in several cellular processes such as the homotypic cell adhesion functions of IFNs and cellular anti-proliferative activities. We previously showed that the IFITM3 single nucleotide polymorphisms (SNPs) associated with susceptibility...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.09.026
更新日期:2013-11-01 00:00:00
abstract::We studied isotype profiles of anti-HIV antibodies (Ab) in HIV-1-infected African patients with high viral loads and major B cell dysfunction. We focussed on IgG1, IgG3, and IgA as these classes and subclasses tend to support neutralizing functions against HIV. Total IgG1, IgG3 and IgA were detected in the plasma of b...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.02.004
更新日期:2004-04-30 00:00:00
abstract::It was attempted to monitor the immunological response of monoclonal antibodies directed to human alkaline phosphatase in ancient Egyptian bones from the ptolemeic period. The intactness of the respective epitopes of the bone enzyme was successfully demonstrated in an ELISA. Fortunately, the mummified bone was not con...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(95)02467-0
更新日期:1995-12-01 00:00:00