Abstract：
:The earliest T-cell precursor population in the adult mouse thymus (low CD4 precursors) may be divided into 85% of cells expressing surface Mel-14 (LECAM-1, the lymphocyte homing receptor) and 15% of cells which are Mel-14. To date, this is the only surface marker for which we have found this population to be heterogeneous. The precursor activity of the Mel-14+ and Mel-14- subpopulation was assessed by both intrathymic and intravenous transfer of sorted cells into Ly5 congenic irradiated recipient mice. On both a cell-for-cell and a total activity basis, almost all precursor activity was associated with the Mel-14+ cells. No segregation was seen between T-cell, B-cell and dendritic cell precursor activity of the low CD4 population, all activities being concentrated in the Mel-14+ fraction. This strengthens the hypothesis that one precursor cell has the potential to form all three lineages.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Wu L,D'Amico Adoi
10.1016/0165-2478(94)90177-5subject
Has Abstractpub_date
1994-05-01 00:00:00pages
89-92issue
2eissn
0165-2478issn
1879-0542pii
0165-2478(94)90177-5journal_volume
40pub_type
杂志文章abstract：:Stimulation of tonsillar B-lymphocytes with CD40 antibodies and IL-4 leads to homotypic adhesion, proliferation, and differentiation into Ig-producing cells. It also leads to the production of IL-6, a pleiotropic cytokine involved in B-cell maturation and differentiation. To assess the importance of IL-6 in the differ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00140-5
更新日期：1998-03-01 00:00:00
abstract：:Previous studies have demonstrated that culture supernatants of LPS-stimulated murine splenic B lymphocytes (BLPSSN) are able to inhibit the growth of freshly isolated B cells via an IgM antibody. In this work we investigated the progress of LPS-activated B lymphocytes through the cell cycle in the presence of this an...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(92)90070-5
更新日期：1992-08-01 00:00:00
abstract：:The HIV-1 envelope protein contains several regions with amino acid homology to HLA class I and class II molecules. We evaluated possible changes in antibody responses to those regions during vaccination with rgp 160 produced in a baculovirus system. Forty asymptomatic HIV-infected patients with CD4 cell counts above ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90125-2
更新日期：1994-07-01 00:00:00
abstract：:Antibody-dependent and spontaneous lymphocytotoxicity of blood mononuclear cells from 15 patients with chronic renal failure was studied in allogeneic K-562 and xenogeneic chicken erythrocyte test systems. Both antibody-dependent and spontaneous cytotoxic activities were significantly decreased in uremic patients as c...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(81)90003-1
更新日期：1981-11-01 00:00:00
abstract：:In contrast to defibrinated blood, cells isolated from heparinized blood give lower T-lymphoproliferative responses. Such responses can be also suppressed by addition of heparin to lymphocyte cultures. Platelets inhibit T cell proliferation and B cell differentiation, but their interactions with heparin may produce co...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90115-q
更新日期：1991-05-01 00:00:00
abstract：:In recent years, several investigators have shown that transfer of dendritic cells (DC) prevents diabetes development in non-obese diabetic (NOD) mice. Accumulating evidences showing that DC cultured in medium containing fetal calf serum (FCS) can induce a dominant unspecific immune response in tumor models after i.v....
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2006.11.007
更新日期：2007-02-15 00:00:00
abstract：:Fibrous plaques and intimal thickenings of 5 femoral and 5 iliac human arteries obtained at surgery were processed for indirect and double-labeling immunoelectron microscopy using an affinity purified rabbit IgG anti-C5b-9 neoantigen and the EBM 11 monoclonal antibody anti-human macrophages. The C5b-9 complexes were l...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(89)90039-4
更新日期：1989-03-01 00:00:00
abstract：:Salmonella enterica serovars infect a broad range of mammalian hosts, including humans, causing both gastrointestinal and systemic diseases. Effective immune responses to Salmonella infections depend largely on CD4+ T cell activation by dendritic cells (DCs). Bacteria are internalised by intestinal DCs and respond by ...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2019.01.006
更新日期：2019-11-01 00:00:00
abstract：:A panel of synthetic peptides representing human lymphocyte antigen (HLA) B8, other class I and class II restricted T cell epitopes and two B cell epitopes, were all able to compete with recognition of a HLA B8 restricted epitope by a cytotoxic T cell clone. Competition was obtained when the competitor peptides were a...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90048-f
更新日期：1991-11-01 00:00:00
abstract：:The antigen receptors on the surface of B- and T-lymphocytes are complexes of several integral membrane proteins, essential for their proper expression and function. Recent studies demonstrated that transmembrane (TM) domains of the components of these receptors play a critical role in their association and function. ...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/s0165-2478(98)00100-x
更新日期：1998-12-01 00:00:00
abstract：:IgE-mediated activation of basophil granulocytes and mast cells follows a bell-shaped dose-response curve. The decreased activation at supraoptimal allergen stimulation is thought to be associated with SH2-containing inositol-5'-phosphatase 1 (SHIP-1). SHIP-1 phosphorylation is inversely related to IgE-mediated releas...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2019.04.003
更新日期：2019-06-01 00:00:00
abstract：:Peripheral blood from 11 newly diagnosed patients with insulin-dependent diabetes mellitus (IDDM) was studied for the proportion of monoclonal antibody (HNK 1, Leu 7) defined natural killer (NK) cells using a fluorescence-activated cell sorter analyzer. The proportion of Leu 7+ cells in patients with IDDM (7.0 +/- 4.0...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90056-7
更新日期：1984-01-01 00:00:00
abstract：:Interleukin-18 (IL-18) is a novel pro-inflammatory cytokine which has been implicated to play a pathogenic role in rheumatoid arthritis (RA). Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis in rheumatoid synoviocytes. In present study, we examined the effect of IL-18 on VEGF productio...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.10.020
更新日期：2006-03-15 00:00:00
abstract：:To explore the genetic association of single nucleotide polymorphisms (SNPs) in the coding region of the NOTCH4, exon 3 C+1297T and exon 5 A+3063G, in a case-control analysis of 58 rheumatoid arthritis (RA) and 98 alopecia areata (AA) and 100 ethnically matched healthy subjects. NOTCH4 polymorphisms were genotyped by ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2013.01.002
更新日期：2013-02-01 00:00:00
abstract：:Granulomatous inflammation around parasite eggs is the prominent lesion in human schistosomiasis. Studies have suggested the involvement of a series of suppressive mechanisms in the control of this reaction, such as macrophages, cytokines, idiotypic interactions and immune complexes (IC). The studies examine the role ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00026-1
更新日期：1998-06-01 00:00:00
abstract：:Studies on natural cytotoxicity of peripheral blood monocytes were conducted in patients with acute viral hepatitis B, patients with chronic aggressive hepatitis etiopathogenically linked to viral hepatitis B, and in asymptomatic carriers of HBs antigen. In the majority of cases of viral hepatitis in the acute stage o...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90016-1
更新日期：1985-01-01 00:00:00
abstract：:Apoptosis markers and the rate of lymphocyte apoptosis were followed in the peripheral blood of HIV infected persons at various stages of disease. Our study suggests that the early increase in memory cells following therapy may also be due to a significant decrease in apoptosis in this subset. The intrinsic resistance...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00167-9
更新日期：1999-03-01 00:00:00
abstract：:Human natural killer (NK) cell activity was not significantly affected by leukotriene (LT) B4 over a wide concentration range (10(-6)-10(-14) M), whether added directly to the NK cell assay or after preincubation of effector cells for 2 h with the drug before addition of Cr labelled K562 target cells. In addition, LTB...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90003-3
更新日期：1985-01-01 00:00:00
abstract：:T cell functions are regulated by multiple signaling cascades, including the MKK4-JNK (c-Jun NH2 terminal kinase) pathway. However, the mechanism regulating the MKK4-JNK axis in T cells remains unclear. Herein, we demonstrated that protein acetylation modulates JNK activity induced by T cell receptor (TCR) activation....
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.12.002
更新日期：2018-02-01 00:00:00
abstract：:Crohn's disease and ulcerative colitis, known together as inflammatory bowel disease (IBD), are severe autoimmune disorders now causing gut inflammation and ulceration, among other symptoms, in up to 1 in 250 people worldwide. Incidence and prevalence of IBD have been increasing dramatically over the past several deca...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2014.07.014
更新日期：2014-12-01 00:00:00
abstract：:A consensus motif for a bovine major histocompatibility complex (MHC) class I molecule, A20, was derived from parainfluenza type-3 (PI-3) virus-infected muscle-derived fibroblast cells and peripheral blood leukocytes by extraction of the naturally processed peptides from MHC class I molecules by treatment with TFA and...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)00244-l
更新日期：1995-02-01 00:00:00
abstract：:To monitor genetically-controlled cytokine-producing ability in mice in vitro, we developed a high-density cell culture system, which is preferable for inducing CD4+ T cell-dependent self-priming responses without any antigenic stimulation. When BALB/c spleen cells were cultured at high density (over 1.0 x 10(7) cells...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(99)00143-1
更新日期：1999-12-01 00:00:00
abstract：:Both CD8 and CD2 are T cell surface receptors involved in physical cell interaction and in transmembrane signalling. The present paper addresses their role in the induction of two different functions of the cloned murine cytotoxic T cell C196: target cell lysis and IFN-gamma production. These functions were induced in...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90018-6
更新日期：1991-10-01 00:00:00
abstract：:To elucidate the role of macrophage migration inhibitory factor (MIF) in ocular inflammation, we examined the localization of MIF in the normal anterior uveal tract of rats. Immunohistochemistry using an anti-MIF antibody revealed that MIF was present in non-pigment epithelial cells of the ciliary body and the epithel...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(96)02600-4
更新日期：1996-10-01 00:00:00
abstract：:The phenomenon of virus neutralization is a function of three variables: the antibody (Ab), the virus and the target cell. Variation in any one of these parameters may drastically affect the results of assays for neutralization. In focusing on the virus as a variable in assays for the neutralization of HIV-1, it has b...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/0165-2478(96)02560-6
更新日期：1996-06-01 00:00:00
abstract：:Toll-like receptors (TLR) are critical in the activation of macrophages by bacterial products. It has been shown that TLR2 and TLR4 mediate lipopolysaccharide (LPS) and lipoproteins signal transduction, respectively. Regulation of TLR2 and TLR4 expression by LPS was considered to be one of the mechanisms to control th...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(02)00010-x
更新日期：2002-05-01 00:00:00
abstract：:Natural killer (NK) cells and cytotoxic T lymphocytes (CTL), the functional coordination of which are governed by various signal substances, are crucial in the body's defense of tumor and virus-infected cells. We investigated the role of various neurotransmitters and hormones on the regulation of functional parameters...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2003.09.004
更新日期：2003-12-15 00:00:00
abstract：:In rheumatoid arthritis, the synovium exhibits fibroblast hyperplasia and dynamic infiltration of activated T cells. Interaction between rheumatoid arthritis synovial fibroblasts (RASF) and T cell subsets such as Th17 cells can stimulate RASF to express IL-6, IL-8, CCL20, and other proinflammatory mediators of joint d...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.04.001
更新日期：2016-06-01 00:00:00
abstract：:While the spleen is an active site for myelopoiesis during the late embryonal and perinatal stages, the activity is gradually lost later. However, myelopoiesis in the adult spleen can be reactivated by irradiation or various stimulants. In this study we investigated factors which determine the myelopoiesis-supporting ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(93)90091-f
更新日期：1993-02-01 00:00:00
abstract：:Seroma is a frequent complication of breast cancer surgery, the etiology of which remains indefinite. It represents a subcutaneous accumulation of fluid frequently reported after surgical procedures such as axillary lymph node dissection. Despite previous studies have associated seroma fluid to an inflammatory exudate...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2010.03.002
更新日期：2010-06-15 00:00:00
