Abstract:
:In contrast to defibrinated blood, cells isolated from heparinized blood give lower T-lymphoproliferative responses. Such responses can be also suppressed by addition of heparin to lymphocyte cultures. Platelets inhibit T cell proliferation and B cell differentiation, but their interactions with heparin may produce contrasting effects on different immune functions.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Górski A,Wasik M,Stepień-Sopniewska B,Glapiński Tdoi
10.1016/0165-2478(91)90115-qsubject
Has Abstractpub_date
1991-05-01 00:00:00pages
161-5issue
2eissn
0165-2478issn
1879-0542pii
0165-2478(91)90115-Qjournal_volume
28pub_type
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journal_title:Immunology letters
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(01)00194-8
更新日期:2001-05-01 00:00:00
abstract::Pulmonary intraparenchymal leukocytes were purified from normal mice. By flow cytometry, 20-30% of the lymphocytes were positive for the expression of Mac1, a cell-surface antigen largely restricted to macrophages, neutrophils and natural killer (NK) cells. Sorted Mac1+ lung lymphocytes were large and had abundant cyt...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(95)00034-3
更新日期:1995-05-01 00:00:00
abstract::Investigating the functional effects of anti-T cell monoclonal antibodies (obtained through the Second International Workshop on Human Leucocyte Differentiation Antigens), antibodies to the sheep red cell receptor (CD2) were found to block lectin-dependent cytotoxicity. Blocking was seen with all anti-CD2 reagents tes...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(85)90151-8
更新日期:1985-01-01 00:00:00
abstract::DNA-dependent RNA polymerase was partially purified from wheat germ extract and tested for inhibition by antinuclear autoantibodies from the sera of patients with connective tissue diseases. The enzyme was inhibited by anti-DNA and by autoantibodies to the nuclear ribonucleoprotein nRNP. Autoantibodies to other ribonu...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(83)90093-7
更新日期:1983-03-01 00:00:00
abstract::Corticotropin releasing hormone (CRH) is a major regulator of the stress response. This study examined whether CRH regulates interleukin-18 expression on microglia, BV2. Our data show that CRH enhanced IL-18 expression and significantly induced the secretion of functional IL-18 protein. Furthermore, CRH induced IL-18 ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.12.003
更新日期:2005-05-15 00:00:00
abstract::Colonization with Streptococcus pneumoniae (S. pneumoniae) is associated with an increased risk for recurrent wheeze and asthma. Killed S. pneumoniae showed some potential as an effective immunomodulatory therapy in a murine model of asthma. Murine studies demonstrated protection against allergic asthma by symbiotic b...
journal_title:Immunology letters
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更新日期:2015-03-01 00:00:00
abstract::Administration of human recombinant interleukin-2 (RIL-2) into congenitally athymic (nu/nu) mice carrying subcutaneous transplants of HeLa, HU 609T and T24B human carcinoma cells partially inhibited growth of the human tumor xenografts. In vitro activation of nu/nu spleen cells with human RIL-2 resulted in generation ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90013-7
更新日期:1987-04-01 00:00:00
abstract::Mimotopes derived from peptide phage display libraries may reproduce basic functions of epitopes including their antigenicity. In case of toxins, this property makes phage displayed mimotopes highly specific vaccine components free of the toxicity. To explore the potential of mimotopes for vaccine development, their a...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(01)00320-0
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Polygonum orientale L. (family: Polygonaceae), named Hongcao in China, has effects of dispelling wind and dampness, promoting blood circulation, and relieving pain. Our group has already studied and confirmed that POEa and POEe (ethyl acetate and ethyl ether extract of P. orientale, respectively)...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2018.11.009
更新日期:2018-09-01 00:00:00
abstract::The present study was conducted to investigate the mode of cell death of bone marrow cells (BMC) treated in vivo or in vitro with gangliosides (DLG) derived from a T cell lymphoma, designated as Dalton's lymphoma (DL). BMC undergoing cell death showed morphological features characteristic to apoptosis such as cell shr...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(00)00156-5
更新日期:2000-04-03 00:00:00
abstract::At least three B cell subsets, B-1a (Ly-1B), B-1b and B-2, are present in the mouse periphery. B-1a and B1-b cells represent a small population in the adult spleen and are abundant in the peritonial and pleural cavities. It has been demonstrated in our laboratory that B-1b cells spontaneously proliferated in stationar...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(02)00266-3
更新日期:2003-03-03 00:00:00
abstract::The experimental infection of macaques with simian immunodeficiency virus (SIV) has provided strong evidence that it may be possible to develop a vaccine against AIDS. Live attenuated SIV vaccines have been found to confer the most potent protection against challenge with a variety of pathogenic viruses. This article ...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/s0165-2478(98)00153-9
更新日期:1999-03-01 00:00:00
abstract::As shown earlier, the cells transformed in vitro by several different oncogenes, or spontaneously, during in vivo growth in normal hosts would be gradually replaced by the highly-tumorigenic descendants co-expressing high H2O2-catabolizing and PGE2-releasing activities. Acquisition of (H2O2(CA) + PGE(S)) phenotype pro...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(99)00123-6
更新日期:1999-10-01 00:00:00
abstract::The basic functions of the immune system are protection from pathogens and maintenance of tolerance to self. The maintenance of commensal microbiota at mucosal surfaces adds a layer of complexity to these basic functions. Recent reports suggest follicular helper T cells (Tfh), a CD4(+) T cell subset specialized to pro...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2014.07.015
更新日期:2014-12-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90050-x
更新日期:1992-05-01 00:00:00
abstract::Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective way to cure hematological malignancies. However, graft-versus-host disease (GVHD) following transplantation limits the clinical application to some extent. The donor T lymphocytes play a central role in the occurrence and development of GVH...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2011.01.010
更新日期:2011-05-01 00:00:00
abstract::We have recently generated CD4 clones from BALB/c mice immunized with a plasmid DNA containing the gene encoding for the catalytic domain of trans-sialidase, an important enzyme expressed on the surface of Trypanosoma cruzi trypomastigotes. These clones allowed us to study in vitro the interaction between T cells and ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(00)00205-4
更新日期:2000-07-03 00:00:00
abstract::Flt3 ligand, a recently described growth factor affecting early hematopoietic progenitor cells, can also support the expansion of dendritic cells secreting IL-12. Its potential use in a clinical setting has been suggested. Here, we studied the effect of in situ delivery of Flt3 ligand plasmid (FL) on the antibody resp...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(02)00039-1
更新日期:2002-05-01 00:00:00
abstract::The physiological role(s) of fetuin, a protein present in plasma and many tissues of developing animals at levels much higher than in the adult, is unknown. Here we show that fetuin can modify the responses of macrophages to lipopolysaccharide (LPS) stimulation. At concentrations of fetuin in the medium, corresponding...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(97)00126-0
更新日期:1998-01-01 00:00:00
abstract::While the pathophysiology of burn injury is well established in young adults, the factors that contribute to pathogenesis and increased death in elderly burn patients are not defined. The purpose of this study is to determine the effects of burn injury on mesenteric lymph node (MLN) T cell responses in young and aged ...
journal_title:Immunology letters
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更新日期:2003-04-03 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(95)00087-3
更新日期:1995-09-01 00:00:00
abstract::A murine monoclonal antibody (IgG) has been generated that binds to DNA modified with osmium tetroxide in the presence of 2,2'-bipyridine and does not interact with unmodified DNA. Reactivity of the antibody was tested by gel retardation assay, ELISA, dot-binding assay and immunoblotting. The results obtained suggest ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90084-n
更新日期:1991-09-01 00:00:00
abstract::Proliferation of mouse lymph node lymphocytes in response to concanavalin A in serum-free medium is normally dependent upon the presence of transferrin. In the absence of transferrin, little proliferation occurred, but the response was restored by addition of the iron complex of pyridoxal isonicotinoyl hydrazone (FePI...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90071-x
更新日期:1987-05-01 00:00:00
abstract::The antibody response in humans naturally primed to a malaria vaccine candidate antigen (Pf155/RESA) is genetically regulated. Here, the impact of antigen presenting cells (APC) on the control of in vitro T-cell responses induced by Pf155/RESA or synthetic peptides corresponding to its major Pf155/RESA epitopes was st...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)00163-4
更新日期:1994-12-01 00:00:00
abstract::Tuberculosis is an infectious disease that affects millions of people worldwide with an annual mortality rate of 1.3 million. The mechanisms contributing to the loss of balance of immune responses and progression to active tuberculosis disease are unknown. Although CD4+ and CD8+ T cells and the cytokines they produce ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.03.009
更新日期:2014-07-01 00:00:00
abstract::Activation of the NF-κB pathway is causally linked to initiation and progression of diverse cancers. Therefore, IKKβ, the key regulatory kinase of the canonical NF-κB pathway, should be a logical target for cancer treatment. However, existing IKKβ inhibitors are known to induce paradoxical immune activation, which lim...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2015.10.011
更新日期:2015-12-01 00:00:00
abstract::Leukaemic blood lymphocytes from patients with B prolymphocytic leukaemia express the common acute lymphoblastic leukaemia antigen (CALLA). The in vitro incubation of prolymphocytes with leucocyte conditioned medium produced the acquisition of plasma cell morphology, of intracytoplasmic immunoglobulins and the simulta...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(85)90005-7
更新日期:1985-01-01 00:00:00
abstract::This study aimed to investigate the influence of physical activity in innate immunity to conduce to an effective antitumoral immune response analyzing the phenotype and activation status of infiltrating cells. We analysed the intracellular cytokines and the transcription factors of tumor infiltrating lymphocytes (TILS...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2017.08.007
更新日期:2017-10-01 00:00:00
abstract::To test whether apoptotic thymocytes can be identified by altered packing of lipids in their plasma membranes, thymocytes were isolated from mice injected with hydrocortisone and stained with merocyanine 540 (MC540), a fluorescent probe sensitive to lipid packing. At 9-10 h after injection, a subpopulation of H2-Klo c...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90101-7
更新日期:1993-06-01 00:00:00