Abstract：
:Between the ages of 2 to approximately 11 days mice respond to a challenge with syngeneic IgE by producing anti-IgE antibodies; by the age of 2 weeks they are unresponsive. Even adult mice, however, produce high titers of anti-IgE antibodies when immunized with a conjugate of syngeneic IgE and a foreign antigen such as keyhole limpet hemocyanin (KLH), indicating that adult tolerance to unconjugated IgE resides in the T-cell compartment. The loss of responsiveness in 2-week-old mice follows closely after the first appearance of IgE-secreting cells and detectable serum IgE. This suggests that the delayed onset of tolerance is attributable to the delay in synthesis of IgE. Data presented here provide support for this hypothesis. A further delay in the initial synthesis of IgE, induced by neonatal administration of anti-IgM antibodies, caused a corresponding extension of the period after birth during which mice remain responsive to unconjugated IgE.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Haba S,Nisonoff Adoi
10.1016/0165-2478(95)00087-3subject
Has Abstractpub_date
1995-09-01 00:00:00pages
205-8issue
3eissn
0165-2478issn
1879-0542pii
0165247895000873journal_volume
47pub_type
杂志文章abstract：:Immunodeficiencies can lead to alterations of the gut microbiome that render it pathogenic and capable of transmitting disease to naïve hosts. Here, we review the role of Toll-like receptor (TLR) 5, the innate receptor for bacterial flagellin, in immune responses to the normal gut microbiota with a focus its role on a...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2014.07.017
更新日期：2014-12-01 00:00:00
abstract：:The CD4+ T-lymphocyte absolute count (CD4ac), CD4+ T-lymphocyte percentage (CD4%) and total lymphocyte count (Løac) were assessed in HIV-seropositive intravenous drug users (IVDU) with reference to their correlation with the clinical categories A, B, and C as stipulated by the Centre of Disease Control and Prevention,...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90219-4
更新日期：1994-12-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90044-q
更新日期：1990-06-01 00:00:00
abstract：:DNA-dependent RNA polymerase was partially purified from wheat germ extract and tested for inhibition by antinuclear autoantibodies from the sera of patients with connective tissue diseases. The enzyme was inhibited by anti-DNA and by autoantibodies to the nuclear ribonucleoprotein nRNP. Autoantibodies to other ribonu...
journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：1983-03-01 00:00:00
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journal_title：Immunology letters
pub_type： 信件
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更新日期：2009-09-22 00:00:00
abstract：:Antigen receptor (AgR) crosslinking by antigens or AgR-specific antibodies induces a cascade of enzymatic events in lymphocytes which involves activation of several non-receptor tyrosine- and serine/threonine kinases, phosphatases, phospholipases, etc. Here we show data demonstrating that a thiol group-reactive protei...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(93)90031-v
更新日期：1993-08-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00102-3
更新日期：1999-02-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.07.014
更新日期：2016-09-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(96)02622-3
更新日期：1996-11-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90044-x
更新日期：1982-05-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.02.011
更新日期：2005-07-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2015.06.017
更新日期：2015-10-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00002-9
更新日期：1998-04-01 00:00:00
abstract：:The administration of protein antigens into earthworms Lumbricus terrestris and Eisenia foetida induces the formation of antigen-binding protein (ABP) with the maximum response occurring between days 4 and 8. High proteolytic activities observed both in coelomocytes and in coelomic fluids cause rapid antigen degradati...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90145-7
更新日期：1994-07-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.03.009
更新日期：2014-07-01 00:00:00
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journal_title：Immunology letters
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0165-2478(01)00224-3
更新日期：2001-08-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.03.001
更新日期：2009-04-27 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)02712-0
更新日期：1997-06-01 00:00:00
abstract：:The observation that protective immunity induced by immunization with radiation attenuated Plasmodium berghei and Plasmodium yoelii sporozoites is dependent on CD8+ T lymphocytes in some strains of mice led us to speculate that immunization with sporozoites induces cytotoxic T lymphocytes (CTL) that recognize malaria ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90087-7
更新日期：1990-08-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(01)00340-6
更新日期：2002-04-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(02)00209-2
更新日期：2003-01-02 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2020.04.006
更新日期：2020-07-01 00:00:00
abstract：:Transforming growth factor-beta (TGF-beta) is usually known as an immunosuppressive cytokine, but we and others have shown stimulatory effects of TGF-beta on activation of Th2 T-lymphocytes. In the present investigation we have studied the effect of TGF-beta1 on phosphorylation of ERK, a MAP-kinase downstream of the R...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00184-x
更新日期：2000-06-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90056-3
更新日期：1987-10-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2018.11.005
更新日期：2019-08-01 00:00:00
abstract：:Partially purified IgE receptor(s) of rat basophilic leukemia cells (RBL) designated R and H and having apparent molecular weight of 45,000 and 55,000 daltons, respectively, were subjected to proteolysis with papain. Polyacrylamide gel electrophoresis of the digests in the presence of sodium dodecyl sulfate revealed a...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90029-3
更新日期：1982-03-01 00:00:00
abstract：:Many alterations of innate and adaptive immunity are common in the aging population, which reflect a deterioration of the immune system, and have lead to the terms "immune aging" or "immunosenescence". Systems Biology aims to the comprehensive knowledge of the structure, dynamics, control and design that define a give...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2014.09.009
更新日期：2014-11-01 00:00:00
abstract：:Six murine monoclonal antibodies, AT-1, 2, 3, 4, 5, and 6 were produced against human recombinant tumor necrosis factor (gamma TNF). AT-1, -2, -3, -4, and -6 were IgG1, and AT-5 was IgG2a. AT-1, -2, and -3 neutralized the activity of gamma TNF (2 X 10(3) U/ml) over a range of dilutions between 5 and 500 micrograms/ml ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(88)90003-x
更新日期：1988-04-01 00:00:00
abstract：:The intestinal immune system maintains a delicate balance between immunogenicity against invading pathogens and tolerance of the commensal microbiota and food antigens. Dendritic cells (DC) generate primary T-cell responses, and determine whether these responses are immunogenic or tolerogenic. The regulatory role of D...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2013.01.007
更新日期：2013-02-01 00:00:00
abstract：:The ability of immune checkpoint inhibitors (ICIs) to reactivate the killing function of the immune system to tumor cells has led to long lasting immune response presenting highly promising clinical advances. Recently, immune checkpoint inhibitors related resistance due to the specialized tumor microenvironment has al...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2019.03.006
更新日期：2020-04-01 00:00:00
