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CD55, CD59, factor H and factor H-like 1 gene expression analysis in tumors of the ovary and corpus uteri origin.

Abstract：

:The expression level of complement regulators in ovarian and corpus uteri tumors was not fully established so far. In current manuscript we performed gene expression analysis by the real-time PCR approach to investigate both membrane bound - CD55 and CD59 and fluid phase - factor H and factor H-like 1 complement regulators. We found increased CD55 expression in corpus uteri tumors when compared to control tissues, whereas in ovarian cancer CD55 expression was lower than in control sections. Additionally we found CD59 expression to be more prominent in ovarian cancer than in corpus uteri tumor samples. We observed also the strong positive correlation between the level of expression of the whole group of regulators, which was particularly significant between the expression of factor H and factor H- like 1. In conclusion we present novel results which implicates different role of particular complement inhibitors in the regulation of the complement system in two cancer types examined. Strong positive correlation between examined proteins implicates similar pattern of the regulation which should be taken into consideration with regards to the possible immunotherapy applied as adjuvant therapeutic approach in these two indications. The inhibition of complement regulation may serve as a strategy to potentiate the efficacy of such treatment.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Kapka-Skrzypczak L,Wolinska E,Szparecki G,Wilczynski GM,Czajka M,Skrzypczak M

doi

10.1016/j.imlet.2015.06.017

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

67-71

issue

2

eissn

0165-2478

issn

1879-0542

pii

S0165-2478(15)30004-3

journal_volume

167

pub_type

杂志文章

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