Abstract：
:Dendritic cells (DCs) differentiated in the presence of IL-10 preferentially induce regulatory T-cells and tolerance. Whether the tolerogenic properties displayed by these DCs (Tol-DCs) can be overcome has not been fully explored. Here we show for the first time that Tol-DCs express higher levels of TLR5 mRNA, but not TLR4 or TLR9 mRNA relative to DCs differentiated with GM-CSF and IL-4 (BM-DCs). In response to flagellin, a natural TLR-5 ligand, Tol-DCs produced IL-12 but not IL-10. Unlike Tol-DCs stimulated with LPS, which produce high levels of IL-10 and fail to generate a cognate inflammatory response in CD4(+) T-cells, flagellin-stimulated Tol-DCs promoted the differentiation of CD4(+) T cells with a T-helper 1 phenotype. The divergent T-cell outcomes induced by Tol-DCs in response to different TLR-ligands highlights not only their plasticity, but also points to TLR5 ligation as a potential strategy to overcome tolerance in environments that are otherwise conducive to immune unresponsiveness.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Vicente-Suarez I,Brayer J,Villagra A,Cheng F,Sotomayor EMdoi
10.1016/j.imlet.2009.06.007subject
Has Abstractpub_date
2009-08-15 00:00:00pages
114-8issue
2eissn
0165-2478issn
1879-0542pii
S0165-2478(09)00163-1journal_volume
125pub_type
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