Cellular responses of guinea-pig macrophages to C4a; inhibition of C3a-induced O2- generation by C4a.

abstract：:The monoclonal antibody (mAb) AHT-107 recognized a determinant distal to the interleukin 2 (IL-2) binding site on the p55 subunit of the IL-2 receptor (IL-2R) (the Tac antigen, CD25) of human T lymphoblasts, while the mAb AHT-54 recognized a determinant close to the IL-2 binding site as did the anti-Tac. The AHT-107 i...

journal_title：Immunology letters

authors： Osawa H,Diamantstein T

更新日期：1989-02-01 00:00:00

abstract：:Serum antibodies reactive with intermediate filaments of the cytoskeleton (anti-IF antibodies) are often present in infectious mononucleosis, some other viral diseases, and rheumatoid arthritis. The mechanism of their production is not known, but it is possible that the formation of this and other autoantibodies resul...

journal_title：Immunology letters

authors： Mortazavi-Milani SM,Stierle HE,Holborow EJ

更新日期：1982-10-01 00:00:00

abstract：:Neuraminidases act as a virulence factors for several pathogens that invade the human body through Peyer's patch M-cells. Because of the structural similarity of Aleuria aurantia lectin (AAL) to neuraminidases, we hypothesized that AAL might also target human M-cells. In an in vitro human M-cell co-culture model signi...

journal_title：Immunology letters

authors： Roth-Walter F,Bohle B,Schöll I,Untersmayr E,Scheiner O,Boltz-Nitulescu G,Gabor F,Brayden DJ,Jensen-Jarolim E

更新日期：2005-09-15 00:00:00

abstract：:The diminished expression of HLA-DR on monocytes has been proposed as a reliable marker of immunosuppression occuring during septic shock. The objective of the present observational study was to establish the time-dependent relation between plasma cytokines interleukin (IL)-10, transforming growth factor (TGF)-beta1, ...

journal_title：Immunology letters

authors： Monneret G,Finck ME,Venet F,Debard AL,Bohé J,Bienvenu J,Lepape A

更新日期：2004-09-01 00:00:00

abstract：:Modulation of the IgE response by PHA treatment in relation to animal sex was analysed. Male and female RF mice were immunized with ovalbumin in aluminum hydroxide gel and PHA was injected 1 or 2 days before immunization. Castrated mice were also immunized and received PHA on day -2. The results show that the IgE resp...

journal_title：Immunology letters

authors： Astorquiza MI,Cisternas C,Leal X

更新日期：1987-10-01 00:00:00

abstract：:Replication-competent retroviruses are not known to encode or induce nuclear antigens that are immunogenic in their natural hosts. We describe here the detection of a human T-lymphotropic virus (type I and type II) associated nuclear antigen (HTLV-NA) by an anticomplement immunofluorescence assay. Antibody to HTLV-NA ...

journal_title：Immunology letters

authors： Lee TH,Essex M,Klein E,Klein G

更新日期：1986-08-01 00:00:00

abstract：:A major factor in the ability of the placenta to avoid allograft rejection is the differential expression of MHC class I antigens on its surface. Using monoclonal antibodies and the electron microscopic immunogold technique, we have demonstrated that only the pregnancy-associated (Pa) antigen, which carries a broadly ...

journal_title：Immunology letters

authors： Kanbour A,Macpherson TA,Kunz HW,Gill TJ 3rd

更新日期：1987-12-01 00:00:00

abstract：:Herein, we summarize the steps of a common scientific path taken by the two Guest Editors, an Anesthesiologist (EA) and an Immunologist (AS), and started 25 years ago at the National Cancer Institute in Rome. When in 1980 WHO codified the usage of opioids for cancer pain relief, it was matter of debate whether only di...

journal_title：Immunology letters

authors： Santoni A,Arcuri E

更新日期：2020-10-01 00:00:00

abstract：:The binding of nascent human C3b (i.e. the fragment of C3 just after trypsin cleavage) to mouse peritoneal macrophages was demonstrated by immune adherence. Acceptor-bound C3b could be detected longer than 24 h on the cell membrane. The rosette formation and phagocytosis of SRBC coated with anti-SRBC rat IgG was inhib...

journal_title：Immunology letters

authors： Fábry Z,Erdei A,Gergely J

更新日期：1983-06-01 00:00:00

abstract：:DC are unique antigen presenting cells, and their ability to induce proliferation of T cells in a mixed leukocyte reaction (MLR) assay is commonly used for the evaluation of their function. To determine the mechanisms involved in DC-induced T cell activation in a primary MLR assay, a variety of different agents were e...

journal_title：Immunology letters

authors： Tourkova IL,Yurkovetsky ZR,Shurin MR,Shurin GV

更新日期：2001-09-03 00:00:00

abstract：:The human immune system is a complex machinery involving numerous proteins. Proteins located at the cell surface of immune cells are of particular relevance due not only to their participation in the network of interactions that regulate the immune response but also to their potential as excellent targets for diagnost...

journal_title：Immunology letters

authors： Díaz-Ramos MC,Engel P,Bastos R

更新日期：2011-01-30 00:00:00

abstract：:Accumulating evidence has demonstrated the importance of cytotoxic T lymphocytes (CTLs) and helper T lymphocytes in controlling HIV-1 replication. We have elicited immune responses in rhesus monkeys utilizing DNA vaccines augmented by the administration of IL-2/Ig, a fusion protein consisting of interleukin-2 and the ...

journal_title：Immunology letters

authors： Barouch DH,Fu TM,Montefiori DC,Lewis MG,Shiver JW,Letvin NL

更新日期：2001-11-01 00:00:00

abstract：:Tuberculosis (TB) is a highly infectious disease and its early and precise diagnosis is essential to reduce morbidity and mortality of patients. Since the routine diagnostic tests (like Monteux, AFB smear microscopy, chest X-Ray) do not give infallible results, additional tests are always recommended. Therefore to add...

journal_title：Immunology letters

authors： Tripathi DK,Srivastava K,Nagpal KL,Shukla PK,Srivastava KK

更新日期：2019-05-01 00:00:00

abstract：:ErbB2, a member of the EGF receptor family of tyrosine kinases is overexpressed on many tumor cells of epithelial origin and is the molecular target of trastuzumab (Herceptin), the first humanized antibody used in the therapy of solid tumors. Trastuzumab, which is thought to act, at least in part, by downregulating Er...

journal_title：Immunology letters

authors： Zsebik B,Citri A,Isola J,Yarden Y,Szöllosi J,Vereb G

更新日期：2006-04-15 00:00:00

abstract：:Leukaemic blood lymphocytes from patients with B prolymphocytic leukaemia express the common acute lymphoblastic leukaemia antigen (CALLA). The in vitro incubation of prolymphocytes with leucocyte conditioned medium produced the acquisition of plasma cell morphology, of intracytoplasmic immunoglobulins and the simulta...

journal_title：Immunology letters

authors： de Paoli P,Battistin S,Fantin O,Nimis R,Reitano M,Santini G

更新日期：1985-01-01 00:00:00

abstract：:The mast cell function-associated antigen (MAFA) is a type II membranal glycoprotein expressed by rat mast cells and basophils. MAFA clustering by its specific monoclonal antibody, (mAb) G63, efficiently inhibits the FcvarepsilonRI induced secretory response of mucosal-type mast cells of the RBL-2H3 line, as well as b...

journal_title：Immunology letters

authors： Abramson J,Pecht I

更新日期：2002-06-03 00:00:00

abstract：:The aim of the present work was to develop an in vitro model of eosinophil cytotoxicity which mimics numerous in vivo situations characterized by complement activation through the alternative pathway. Our results demonstrate that eosinophilic granulocytes from patients with parasitic diseases and blood eosinophilia we...

journal_title：Immunology letters

authors： De Simone C,Ferrari M,Pugnaloni L,Ferrarelli G,Rumi C,Sorice F

更新日期：1986-01-01 00:00:00

abstract：:We report here that Trichosanthin (Tk), a primary active component isolated from a Chinese traditional medicinal herb, Trichosanthes kirilowii, potently inhibits lymphocyte proliferative response in vitro. We found that Tk treatment increased production of the interleukins IL-4 and IL-10, while production of IL-2 and ...

journal_title：Immunology letters

authors： Zhou X,Yang N,Lu L,Ding Q,Jiao Z,Zhou Y,Chou KY

更新日期：2007-05-15 00:00:00

abstract：:Administration of human recombinant interleukin-2 (RIL-2) into congenitally athymic (nu/nu) mice carrying subcutaneous transplants of HeLa, HU 609T and T24B human carcinoma cells partially inhibited growth of the human tumor xenografts. In vitro activation of nu/nu spleen cells with human RIL-2 resulted in generation ...

journal_title：Immunology letters

authors： Bubeník J,Kieler J,Tromholt V,Indrová M,Lotzová E

更新日期：1987-04-01 00:00:00

abstract：:Naive CD4 T cells differentiate into functionally distinct T helper (Th) cells subsets or into regulatory T (Treg) cells in response to the cytokine milieu in which they encounter antigen. A recurring theme in post-thymic CD4 T cell differentiation is the cross-regulation of lineage choice by cytokines and transcripti...

journal_title：Immunology letters

authors： Hadjur S,Bruno L,Hertweck A,Cobb BS,Taylor B,Fisher AG,Merkenschlager M

更新日期：2009-01-29 00:00:00

abstract：:T helper17 (Th17) cells have been demonstrated to participate in the pathogenesis of hepatitis B virus (HBV) associated liver damage. However, the contribution of Th17 cells to immune activation and disease aggravation in patients with HBV infection is not fully clear. In this study, we investigated the Th17 cells fre...

journal_title：Immunology letters

authors： Yang B,Wang Y,Zhao C,Yan W,Che H,Shen C,Zhao M

更新日期：2013-01-01 00:00:00

abstract：:The leukocyte common antigen, CD45, is one of the major glycoproteins on cells of hemopoietic origin showing considerable heterogeneity in both structure and expression. Biochemical heterogeneity has been attributed to differences in the primary sequence and glycosylation. In this paper we report an additional basis f...

journal_title：Immunology letters

authors： Oravecz T,Monostori E,Adrian O,Kurucz E,Andó I

更新日期：1994-04-01 00:00:00

abstract：:It has been shown that engraftment of human peripheral blood lymphocytes (PBL) from Epstein-Barr virus (EBV) seropositive donors in C.B-17/SCID mice is associated with a high incidence of human B cell tumors. More recently, we described a new approach enabling engraftment of human PBL in normal strains of mice or rats...

journal_title：Immunology letters

authors： Marcus H,Burakova T,Shezen E,David M,Canaan A,Lubin I,Reisner Y

更新日期：1996-03-01 00:00:00

abstract：:Silicosis is clinically characterized not only by respiratory disorders but by immunological abnormalities such as the appearance of autoantibodies and complications of autoimmune diseases. Dysregulation of apoptosis, particularly in the Fas/Fas ligand (FasL) pathway, has been considered to play a role in the pathogen...

journal_title：Immunology letters

authors： Otsuki T,Sakaguchi H,Tomokuni A,Aikoh T,Matsuki T,Isozaki Y,Hyodoh F,Kawakami Y,Kusaka M,Kita S,Ueki A

更新日期：2000-05-01 00:00:00

abstract：:B cell activating factor belonging to the TNF family (BAFF, also called BLyS, TALL-1, THANK, or zTNF4) is an important survival factor for B cells, and is able to regulate T cell activation. Recently, we have demonstrated that human soluble BAFF (hsBAFF) potently elevates NK cell activity of murine splenic cells in vi...

journal_title：Immunology letters

authors： Zhang W,Wen L,Huang X,Liang J,Gao W,Zhang S,Chen L

更新日期：2008-10-30 00:00:00

abstract：:Th1 and Th2 cytokine response has been confirmed to be correlated with the pathogenesis of HCV infection. The aim of the study is to investigate the Th1 and Th2 cytokine profiles induced by HCV alternate reading frame protein (F protein) in chronic hepatitis C patients. We assessed the immune responses specific to HCV...

journal_title：Immunology letters

authors： Yue M,Deng X,Zhai X,Xu K,Kong J,Zhang J,Zhou Z,Yu X,Xu X,Liu Y,Zhu D,Zhang Y

更新日期：2013-05-01 00:00:00

abstract：:While the cytoskeletal protein talin binds to the β-chain of LFA-1, the immune cell adaptor SKAP1 (SKAP-55) binds to the α-chain of the same integrin via RapL. Whereas calpain protease cleavage of talin is important for LFA-1 activation, it has been unclear whether SKAP1 can alter the function of talin or its associat...

journal_title：Immunology letters

authors： Lim D,Lu Y,Rudd CE

更新日期：2016-04-01 00:00:00

abstract：:Aging is associated to dysfunctional changes in the immune system, a process termed immunosenescence. Elderly individuals usually present chronic low level inflammation, likely as the consequence of continued exposure to antigens combined with poor immune function, increases in production of pro-inflammatory cytokines...

journal_title：Immunology letters

authors： Campos C,Pera A,Lopez-Fernandez I,Alonso C,Tarazona R,Solana R

更新日期：2014-11-01 00:00:00

abstract：:The quasimonoclonal (QM) mouse provides a model to analyze B cell selection because major B cell antigen receptors (BCR) are composed of the knockin V(H)DJ(H) 17.2.25 (V(H)T) encoded H chain and the lambda1 or lambda2 L chain, thereby being specific for (4-hydoxy-3-nitrophenyl)acetyl (NP). We have reported that during...

journal_title：Immunology letters

authors： Kouyama E,Nishikawa Y,Okazawa T,Magari M,Ohmori H,Kanayama N

更新日期：2007-03-15 00:00:00

abstract：:In spite of impressive results in the treatment of acute lymphoblastic B cell leukemia (B-ALL) with chimeric antigen receptor (CAR) T cells, the clinical outcome of some hematological cancers like follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL) has not been very promising likely due to immunosuppressiv...

journal_title：Immunology letters

authors： Fallah-Mehrjardi K,Mirzaei HR,Masoumi E,Jafarzadeh L,Rostamian H,Khakpoor-Koosheh M,Alishah K,Noorbakhsh F,Hadjati J

更新日期：2020-07-01 00:00:00