Eosinophil-mediated cellular cytotoxicity induced by zymosan-activated serum.

abstract：:The link between innate and adaptive host immune response to Mycobacterium tuberculosis (M.tb) is driven by dendritic cells (DC). In this study, we examined the ability of prevalent clinical strains from south India (S7, S10) and laboratory strain H37Rv (Rv) to induce maturation of monocyte derived dendritic cells (Mo...

journal_title：Immunology letters

authors： Rajashree P,Das SD

更新日期：2008-05-15 00:00:00

abstract：:Numerous studies have dealt with occurrence of dendritic cells in various nonlymphoid organs such as kidney, liver or heart, whereas lymphocyte patterns in these organs have not been analyzed in detail. In the present study, leukocytes were quantified as cells/mm2 in the perivascular, interstitial and parenchymal tiss...

journal_title：Immunology letters

authors： Holzinger C,Zuckermann A,Reinwald C,Imhof M,Schöllhammer A,Kramer G,Wolner E,Steiner G

更新日期：1996-11-01 00:00:00

abstract：:While the pathophysiology of burn injury is well established in young adults, the factors that contribute to pathogenesis and increased death in elderly burn patients are not defined. The purpose of this study is to determine the effects of burn injury on mesenteric lymph node (MLN) T cell responses in young and aged ...

journal_title：Immunology letters

authors： Choudhry MA,Plackett TP,Schilling EM,Faunce DE,Gamelli RL,Kovacs EJ

更新日期：2003-04-03 00:00:00

abstract：:Maturation of dendritic cells is a key step during induction of adaptive immune responses. Multiple pathways and factors are involved in the regulation of dendritic cell maturation. Alternative splicing of pre-mRNA, which is regulated by splicing factors, plays an important role in many biological processes, including...

journal_title：Immunology letters

authors： Jia R,Li X,Yu C,Fan M,Guo J

更新日期：2013-06-01 00:00:00

abstract：:HLA class II molecules play pivotal roles in antigen presentation to CD4+ T cells. We investigated signaling via HLA-DR molecules expressed on CD4+ T cells. When HLA-DR or CD3 molecules on cloned CD4+ T cells were cross-linked by solid-phase mAbs, T cells proliferated, and this resulted in anergy. Whereas cross-linkin...

journal_title：Immunology letters

authors： Kudo H,Matsuoka T,Mitsuya H,Nishimura Y,Matsushita S

更新日期：2002-04-22 00:00:00

abstract：:Two types of inhibition of basic peptide-induced rat mast cell secretion are reported. Pretreatment of rat peritoneal mast cells with Vibrio comma neuraminidase, an enzyme which cleaves sialic acid from oligosaccharides, led to inhibition of 5-hydroxytryptamine release induced by the basic peptides polylysine, cortico...

journal_title：Immunology letters

authors： Coleman JW

更新日期：1982-10-01 00:00:00

abstract：:IgE-mediated activation of basophil granulocytes and mast cells follows a bell-shaped dose-response curve. The decreased activation at supraoptimal allergen stimulation is thought to be associated with SH2-containing inositol-5'-phosphatase 1 (SHIP-1). SHIP-1 phosphorylation is inversely related to IgE-mediated releas...

journal_title：Immunology letters

authors： Rasmussen P,Spillner E,Hoffmann HJ

更新日期：2019-06-01 00:00:00

abstract：:The presence of specific glutamate receptors on T lymphocytes separated from normal human blood was investigated. Upon study of T lymphocytes interaction with [3H]glutamate the last one was found to bind specifically to these cells, Kd = 2.36 x 10(-7) M. Thirteen unlabelled compounds were tested as potential glutamate...

journal_title：Immunology letters

authors： Kostanyan IA,Merkulova MI,Navolotskaya EV,Nurieva RI

更新日期：1997-08-01 00:00:00

abstract：:The spontaneous migration in vitro, production of T cell migration inhibitory factor (TIF) and the response to TIF of OKT4+ and OKT8+ human T cell subsets were studied. The OKT4+ lymphocytes migrated far better than the OKT8+ cells although the movement of both subsets was comparably inhibited by TIF. The OKT8+ subset...

journal_title：Immunology letters

authors： Kowalczyk D,Pryjma J,Zembala M

更新日期：1986-08-01 00:00:00

abstract：:Isolated inherited deficiency states of almost every complement protein have been recognized. Almost all are autosomal recessive traits. Deficiency of the early-acting components C1, C4 and C2 is associated with increased risk of immune complex disease, particularly systemic lupus erythematosus. Patients with deficien...

journal_title：Immunology letters

authors： Alper CA

更新日期：1987-02-01 00:00:00

abstract：:Using embryonic chickens treated with testosterone propionate, the effects of congenital absence of the bursa of Fabricius determined by the frequency of J chain-positive cells was examined in the spleen, thymus and bone marrow at the embryonic and newly hatched stages. J chain-positive cells in the chicks without bur...

journal_title：Immunology letters

authors： Moriya O,Ichikawa Y

更新日期：1984-01-01 00:00:00

abstract：:Psoriasis and psoriatic arthritis (PsA) are common diseases associated with considerable morbidity and disability. Their pathophysiology comprises a dysfunctional stromal-immune cell and cytokine network leading to inflammation of skin, entheses and joints. Recent advances in understanding of disease pathogenesis have...

journal_title：Immunology letters

authors： Hueber AJ,McInnes IB

更新日期：2007-12-15 00:00:00

abstract：:T and B cell receptor repertoires are diversified by variable region gene rearrangement and selected based on functionality and lack of self-reactivity. Repertoires can also be defined based on phenotype and function rather than receptor specificity - such as the diversity of T helper cell subsets. Natural killer (NK)...

journal_title：Immunology letters

authors： Mehr R,Sternberg-Simon M,Michaeli M,Pickman Y

更新日期：2012-11-01 00:00:00

abstract：:Using micro-electrode technique we studied the effects of interleukin-2 (50 ng/ml) on bio-electric activity of rat atrial myocardium under normal conditions and after gradual stretching of the tissue. It was shown that interleukin-2 caused increasing in the duration of action potential at the levels of 25, 50, and 90%...

journal_title：Immunology letters

authors： Aksyonov A,Mitrokhin VM,Mladenov MI

更新日期：2015-09-01 00:00:00

abstract：:Cysticercosis caused by Taenia solium is a very common disease in developing countries that seriously affects human health. Diagnosis can only be confirmed with the aid of computerized tomography or nuclear magnetic resonance (NMR) creating obvious difficulties for epidemiological studies. Reliable immunoassays employ...

journal_title：Immunology letters

authors： Hernández M,Beltrán C,García E,Fragoso G,Gevorkian G,Fleury A,Parkhouse M,Harrison L,Sotelo J,Sciutto E

更新日期：2000-01-10 00:00:00

abstract：:Six murine monoclonal antibodies, AT-1, 2, 3, 4, 5, and 6 were produced against human recombinant tumor necrosis factor (gamma TNF). AT-1, -2, -3, -4, and -6 were IgG1, and AT-5 was IgG2a. AT-1, -2, and -3 neutralized the activity of gamma TNF (2 X 10(3) U/ml) over a range of dilutions between 5 and 500 micrograms/ml ...

journal_title：Immunology letters

authors： Shimamoto Y,Chen RL,Bollon A,Chang A,Khan A

更新日期：1988-04-01 00:00:00

abstract：:Cultured T lymphocytes from pig blood can be activated by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA). Activation is additive with that induced by the mitogenic lectin phytohaemagglutinin (PHA). Activation by TPA differs from that induced by PHA or other mitogenic lectins in that it is not inhibited e...

journal_title：Immunology letters

authors： Kay JE,Meehan RT,Benzie CR

更新日期：1983-01-01 00:00:00

abstract：:Conventional indirect haemagglutination test was performed in rhesus monkey sera (collected from Plasmodium knowlesi infected animals) with and without prior treatment of sera with 2-mercapto-ethanol (2-ME). Surprisingly, many sera samples showed significant enhancement of final titre with 2-ME. The 2-ME enhancement e...

journal_title：Immunology letters

authors： Ravindran B,Biswas S,Hussain QZ,Chaudhuri SN

更新日期：1984-01-01 00:00:00

abstract：INTRODUCTION:Intrahepatic injection of alloantigen prolongs allograft survival and inhibits T-lymphocyte release of both IL-2 and IFN-gamma but not IL-4. This suggests that intrahepatic processing of antigen lead to a predominance of Th2 cell population with inhibition of Th1 cell type. This study examines the effects ...

journal_title：Immunology letters

authors： Chen Y,McKenna GJ,Ong C,Mui AL,Chung SW

更新日期：2002-04-01 00:00:00

abstract：:A majority of natural killer (NK) cells constitutively express intermediate affinity IL2 receptors made of beta gamma chains and respond by way of enhanced cytokine secretion. However, alterations in cytokine sensitivity of purified NK cells with respect to cytokine secretion during immunosenescence have not been exam...

journal_title：Immunology letters

authors： Krishnaraj R,Bhooma T

更新日期：1996-04-01 00:00:00

abstract：:CD70, the ligand of CD27, is a member of the TNF family, which includes molecules essential in the regulation of lymphocyte growth and survival. It is absent on resting lymphocytes but can be induced in vitro with activating stimuli. To extend information about its expression by different T-cell subpopulations, and it...

journal_title：Immunology letters

authors： Brugnoni D,Airò P,Marino R,Notarangelo LD,van Lier RA,Cattaneo R

更新日期：1997-02-01 00:00:00

abstract：:The monoclonal antibody 3A35 which binds mouse polymorphonuclear leucocytes (PMN) and monocytes was injected intravenously (i.v.) into normal mice. A great diminution of circulating PMN was observed. The percentage of PMN passed through a minimum (2.5%) 20 min after antibody injection and returned to normal value (18....

journal_title：Immunology letters

authors： Beurton D,Collet B,Martin A,Toujas L,Bourel D,Genetet B

更新日期：1985-01-01 00:00:00

abstract：:Allogeneic, H-2-incompatible irradiation chimeras (H-2d leads to H-2b) constructed with normal, unmanipulated bone marrow and with marrow-derived factors live long and do not manifest a GvH disease. Their response to primary immunization is deficient but their alloreactivity is normal. This chimeric allotolerance cann...

journal_title：Immunology letters

authors： Pierpaoli W,Maestroni GJ

更新日期：1983-04-01 00:00:00

abstract：:The T cell receptor of gamma delta is normally expressed on a small percentage of peripheral lymphocytes. Although the role of gamma delta T cells in the physiologic immune response is still unknown, there is accumulating evidence that gamma delta T cells may participate in the immune response to mycobacterial and oth...

journal_title：Immunology letters

authors： Ho M,Webster HK,Tongtawe P,Pattanapanyasat K,Weidanz WP

更新日期：1990-08-01 00:00:00

abstract：:Disease-modifying osteoarthritis (OA) therapy is not yet available. Several adjuvant therapies have demonstrated promising results in the treatment of OA. The present study aimed to investigate the therapeutic effects and underlying mechanisms of a combination of Lactobacillus acidophilus, vitamin B, and curcumin in t...

journal_title：Immunology letters

authors： Jhun J,Min HK,Na HS,Kwon JY,Ryu J,Cho KH,Choi J,Jung K,Lee SY,Kim SJ,Yang CW,Park SH,Cho ML

更新日期：2020-12-01 00:00:00

abstract：:The experimental infection of macaques with simian immunodeficiency virus (SIV) has provided strong evidence that it may be possible to develop a vaccine against AIDS. Live attenuated SIV vaccines have been found to confer the most potent protection against challenge with a variety of pathogenic viruses. This article ...

journal_title：Immunology letters

authors： Almond N,Stott J

更新日期：1999-03-01 00:00:00

abstract：:Small soluble IgG aggregates of defined size were prepared from pooled human IgG by gel filtration chromatography, and examined by analytical ultracentrifugation. Three such fractions, dimer-rich, trimer-rich and 25S aggregate were used to inhibit IgG monomer binding in a study of the influence of aggregation in the b...

journal_title：Immunology letters

authors： Ratcliffe A,Stanworth DR

更新日期：1983-01-01 00:00:00

abstract：:Mice lacking suppressor of cytokine signaling 1 (SOCS1) accumulate CD8(+) T lymphocytes in the thymus and in the periphery. Whereas IL-7 and IL-15 promote the generation of CD8 single positive (SP) thymocytes, IL-15 drives the expansion of CD8 T cells in the periphery. Here, we investigated whether increased productio...

journal_title：Immunology letters

authors： Ilangumaran S,Gagnon J,Leblanc C,Poussier P,Ramanathan S

更新日期：2010-08-16 00:00:00

abstract：:The protozoan parasite Trypanosoma cruzi is able to replicate in the cytoplasm of primary resident macrophages, but is killed by activated macrophages. Pretreatment of human macrophages with recombinant IFN-gamma and to a lesser extent with TNF-alpha, induced a significant trypanocidal activity. Furthermore, TNF-alpha...

journal_title：Immunology letters

authors： Muñoz-Fernández MA,Fernández MA,Fresno M

更新日期：1992-06-01 00:00:00

abstract：:This report describes an immunoradiometric assay for Plasmodium falciparum in infected blood, based on a cross-reacting monoclonal antibody (mAb) raised against P. berghei. In this assay, binding of the mAb to intact P. berghei parasites coated on microtiter plates is inhibited by solubilized P. falciparum infected re...

journal_title：Immunology letters

authors： Pass A,Avidor B,Golenser J,Laskov R,Sulitzeanu D

更新日期：1985-01-01 00:00:00