Abstract：
:The human immune system is a complex machinery involving numerous proteins. Proteins located at the cell surface of immune cells are of particular relevance due not only to their participation in the network of interactions that regulate the immune response but also to their potential as excellent targets for diagnostic and therapeutic interventions. The main objective of this project is to generate a comprehensive database of the human cell-surface proteins expressed in immune cells and lymphoid tissues. For this purpose, we have integrated information collected from primary literature, databases and electronic information sources. This manually curated database includes the gene symbol and name of the protein, describes the family that each protein belongs to, indicates their type of extracellular domains, and compiles data regarding their expression. Thus far we have identified and catalogued 1015 genes and proteins. The largest families in this compendium are the Ig superfamily with 195 members (~20%) and the G-protein coupled receptor superfamily with 147 members (~14%). Other abundant families include the C-type lectin and the cytokine receptor families with 43 and 42 members respectively (4%). About 25% of the proteins belong to minor families and approximately 4% lack any clear family assignment. More than 60% of the genes encode proteins without a CD number. This database will serve to boost the production of new monoclonal antibodies and to stimulate studies aimed at characterizing the function of these proteins in the immune system as well as identifying potential new biomarkers and therapeutic targets.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Díaz-Ramos MC,Engel P,Bastos Rdoi
10.1016/j.imlet.2010.09.016subject
Has Abstractpub_date
2011-01-30 00:00:00pages
183-7issue
2eissn
0165-2478issn
1879-0542pii
S0165-2478(10)00252-Xjournal_volume
134pub_type
杂志文章abstract：:Conventional indirect haemagglutination test was performed in rhesus monkey sera (collected from Plasmodium knowlesi infected animals) with and without prior treatment of sera with 2-mercapto-ethanol (2-ME). Surprisingly, many sera samples showed significant enhancement of final titre with 2-ME. The 2-ME enhancement e...
journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：1984-01-01 00:00:00
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journal_title：Immunology letters
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更新日期：2002-06-03 00:00:00
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更新日期：2007-02-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
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更新日期：2002-11-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：2005-02-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00298-4
更新日期：2001-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(89)90069-2
更新日期：1989-01-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90048-9
更新日期：1986-09-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.04.014
更新日期：2016-06-01 00:00:00
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journal_title：Immunology letters
pub_type： 临床试验,杂志文章
doi：10.1016/j.imlet.2019.03.003
更新日期：2019-09-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(89)90039-4
更新日期：1989-03-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2014.03.006
更新日期：2014-07-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2006.12.009
更新日期：2007-03-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(81)90005-5
更新日期：1981-11-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2013.09.026
更新日期：2013-11-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90158-7
更新日期：1991-03-01 00:00:00
abstract：:Rabbit anti-ovalbumin antibodies were found to bind to Swiss NIH 3T3 fibroblasts by indirect immunofluorescence, and to induce DNA synthesis when these cells were arrested in G0 phase of their replicating cycle (G0-S activity). The proof that these effects were related to the ovalbumin paratopes is based on the follow...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90069-1
更新日期：1987-05-01 00:00:00
abstract：:Despite the prominent progress in understanding cancer immunosurveillance mechanisms, there are some types of problems which have been identified to hinder effective and successful immunotherapy of cancers. Such problems have been ascribed to the tumor abilities in the creation of a tolerant milieu that can impair imm...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2020.01.006
更新日期：2020-04-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2011.03.009
更新日期：2011-08-30 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90067-2
更新日期：1986-11-03 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90037-3
更新日期：1984-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2018.01.004
更新日期：2018-04-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(95)02478-6
更新日期：1996-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90114-2
更新日期：1985-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.03.012
更新日期：2017-05-01 00:00:00
abstract：:The complement system is a protein cascade capable of neutralizing invading pathogens. One of its activation pathways is the lectin pathway which is dependent on the binding of MBL or the ficolins. The specificity of L-ficolin binding has been investigated previously and it was observed that binding is dependent on ac...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2008.03.014
更新日期：2008-06-30 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2020.08.002
更新日期：2020-11-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(96)02681-8
更新日期：1997-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00314-x
更新日期：2001-02-01 00:00:00
abstract：:Malaria, a major endemic tropical disease, is caused by the infection of blood cells by Plasmodium protozoa. Most patients control their parasitemia by a not fully understood spleen-dependent mechanism. SDF-1alpha is a chemokine produced by stromal cells such as reticular spleen cells. Nitric oxide (NO) has several im...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2003.05.001
更新日期：2003-10-31 00:00:00
