当前位置： SCI文献检索 > IMMUNOLOGY LETTERS期刊下所有文献 > Cells carrying C5b-9 complement complexes in human atherosclerotic wall.

Cells carrying C5b-9 complement complexes in human atherosclerotic wall.

Abstract：

:Fibrous plaques and intimal thickenings of 5 femoral and 5 iliac human arteries obtained at surgery were processed for indirect and double-labeling immunoelectron microscopy using an affinity purified rabbit IgG anti-C5b-9 neoantigen and the EBM 11 monoclonal antibody anti-human macrophages. The C5b-9 complexes were localized in intact cells, disintegrated cells and cell debris enmeshed in the connective tissue matrix. Some of the cell debris bearing C5b-9 deposits was found to be of macrophage origin. Endocyted or exocyted pieces of membrane with pore-forming C5b-9 complexes were also identified. Damage of cells by complement in atherosclerotic lesions may contribute to atherogenesis.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Rus HG,Niculescu F,Poruţiu D,Ghiurca V,Vlaicu R

doi

10.1016/0165-2478(89)90039-4

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

305-10

issue

4

eissn

0165-2478

issn

1879-0542

pii

0165-2478(89)90039-4

journal_volume

20

pub_type

杂志文章

相关文献

IMMUNOLOGY LETTERS文献大全
  • Two genetic variants in the promoter region of the CCL5 gene are associated with the risk of acute coronary syndrome and with a lower plasma CCL5 concentration.

    abstract：:Acute coronary syndrome (ACS) is a multi-factorial condition with a strong inflammatory component, which is immune-mediated by chemokines. The CCL5 is a chemokine that has been suggested to be an important participant in the development of the atherosclerotic plaque. Therefore, in this work, we evaluated whether three...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2020.10.006

    authors： Herrera-Maya G,Vargas-Alarcon G,Ramirez-Bello J,Perez-Mendez O,Posadas-Sanchez R,Lopez-Marure R,Granados J,Nieto-Lima B,Fragoso JM

    更新日期：2020-12-01 00:00:00

  • Eosinophil-mediated cellular cytotoxicity induced by zymosan-activated serum.

    abstract：:The aim of the present work was to develop an in vitro model of eosinophil cytotoxicity which mimics numerous in vivo situations characterized by complement activation through the alternative pathway. Our results demonstrate that eosinophilic granulocytes from patients with parasitic diseases and blood eosinophilia we...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(86)90078-7

    authors： De Simone C,Ferrari M,Pugnaloni L,Ferrarelli G,Rumi C,Sorice F

    更新日期：1986-01-01 00:00:00

  • Coenzyme Q10 suppresses Th17 cells and osteoclast differentiation and ameliorates experimental autoimmune arthritis mice.

    abstract：:Coenzyme Q10 (CoQ10) is a lipid-soluble antioxidant synthesized in human body. This enzyme promotes immune system function and can be used as a dietary supplement. Rheumatoid arthritis (RA) is an autoimmune disease leading to chronic joint inflammation. RA results in severe destruction of cartilage and disability. Thi...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2015.05.012

    authors： Jhun J,Lee SH,Byun JK,Jeong JH,Kim EK,Lee J,Jung YO,Shin D,Park SH,Cho ML

    更新日期：2015-08-01 00:00:00

  • Analysis of dendritic cell trafficking using EGFP-transgenic mice.

    abstract：:Dendritic cells (DCs) are professional antigen presenting cells, well equipped to initiate an immune response. For effective induction of an immune response, DC should migrate from the periphery to the lymph node to present the antigen to T lymphocytes. Currently, tumor-antigen loaded DCs are used in clinical vaccinat...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(03)00105-6

    authors： Eggert AA,van der Voort R,Torensma R,Moulin V,Boerman OC,Oyen WJ,Punt CJ,Diepstra H,de Boer AJ,Figdor CG,Adema GJ

    更新日期：2003-10-09 00:00:00

  • Intestinal dendritic cells: their role in intestinal inflammation, manipulation by the gut microbiota and differences between mice and men.

    abstract：:The intestinal immune system maintains a delicate balance between immunogenicity against invading pathogens and tolerance of the commensal microbiota and food antigens. Dendritic cells (DC) generate primary T-cell responses, and determine whether these responses are immunogenic or tolerogenic. The regulatory role of D...

    journal_title：Immunology letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.imlet.2013.01.007

    authors： Mann ER,Landy JD,Bernardo D,Peake ST,Hart AL,Al-Hassi HO,Knight SC

    更新日期：2013-02-01 00:00:00

  • Human macrophages respond to LPS in a serum-independent, CD14-dependent manner.

    abstract：:Two crucial mediators of monocyte activation by lipopolysaccharide (LPS) are the acute phase plasma factor, lipopolysaccharide binding protein (LBP) and cell-surface-expressed CD14. Whether macrophage (M phi) recognized and respond to LPS in a similar manner is unknown. Here we show that human monocyte-derived M phi r...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(96)02645-4

    authors： Jungi TW,Brcic M,Eperon S

    更新日期：1996-12-01 00:00:00

  • Effect of intestinal epithelial cell cytokines on mucosal B-cell IgA secretion: enhancing effect of epithelial-derived IL-6 but not TGF-beta on IgA+ B cells.

    abstract：:A variety of cell types may be involved in the regulation of IgA secretion at the intestinal mucosa. Intestinal epithelial cells (IEC) are known to have the capacity to secrete several cytokines which may exert an important regulatory effect on local immunoglobulin secretion by mucosal B cells. In this study, we have ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(98)00112-6

    authors： Goodrich ME,McGee DW

    更新日期：1999-03-15 00:00:00

  • Induction of CD69 antigen expression in peripheral blood mononuclear cells on exposure to silica, but not by asbestos/chrysotile-A.

    abstract：:While cases of silicosis are often complicated by various autoimmune disorders, patients with asbestosis develop malignant tumors such as lung cancer and malignant mesothelioma. These differences may derive from different biological effects, particularly on immunological cells, of silica and asbestos. To find differen...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2004.11.005

    authors： Wu P,Hyodoh F,Hatayama T,Sakaguchi H,Hatada S,Miura Y,Takata-Tomokuni A,Katsuyama H,Otsuki T

    更新日期：2005-04-15 00:00:00

  • Mouse NK1.1+ cytotoxic T cells can be generated by IL-2 exposure from lymphocytes which express an intermediate level of T cell receptor.

    abstract：:NK-like T cells which express the NK1.1 molecule and CD3 (or TCR) of intermediate level (CD3int or TCRint cells) were recently demonstrated to be present in various immune organs, and to have NK-like cytotoxic activity against NK target cells. In this study, we investigated whether NK1.1- T cells could express NK1.1. ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/s0165-2478(98)00014-5

    authors： Ikarashi Y,Maruoka H,Shinohara K,Sugimura T,Terada M,Wakasugi H

    更新日期：1998-04-01 00:00:00

  • Monoclonal antibodies against metallothioneins from the human liver.

    abstract：:Six hybridomas secreting monoclonal antibodies directed against human fetal liver metallothioneins (MTs) have been generated and characterized. One antibody, K5A6, was specific for MT-1, the others recognized all isoMTs present in the human fetal liver. Each of these antibodies showed a unique cross-reactivity pattern...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(92)90193-r

    authors： Van Houdt K,Nicasi I,Van Mechelen E,Veulemans B,De Ley M

    更新日期：1992-03-01 00:00:00

  • Differential effect of low molecular weight alcohols on the Con A stimulation of mouse spleen cells.

    abstract：:Incorporation of [3h]thymidine ([3H]TdR) into concanavalin A (Con A)-stimulated murine splenocytes was found to be enhanced by addition of certain concentrations of ethanol, 2-propanol and acetone. The alcohol/acetone-induced enhancement of the Con A response was found to be accompanied by an increase of the percentag...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(82)90057-8

    authors： Raile A,Hammann KP,Scheiner O,Schulz T,Erdei A,Dierich MP

    更新日期：1982-06-01 00:00:00

  • Lack of effect of LTB4 on human natural killer cell activity and T lymphocyte transformation.

    abstract：:Human natural killer (NK) cell activity was not significantly affected by leukotriene (LT) B4 over a wide concentration range (10(-6)-10(-14) M), whether added directly to the NK cell assay or after preincubation of effector cells for 2 h with the drug before addition of Cr labelled K562 target cells. In addition, LTB...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(85)90003-3

    authors： Hall TJ,Brostoff J

    更新日期：1985-01-01 00:00:00

  • Correction of abnormal T cell subsets by high-dose dexamethasone in patients with chronic idiopathic thrombocytopenic purpura.

    abstract：:Idiopathic thrombocytopenic purpura (ITP) is an acquired autoimmune disorder. Both impaired platelet production and T cell-mediated effects play a role in ITP thrombocytopenia. A Th1 polarization of the immune response, up-regulation of Th17 cells and decreased number of Treg cells have been demonstrated in ITP patien...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2013.08.006

    authors： Li J,Wang Z,Hu S,Zhao X,Cao L

    更新日期：2013-07-01 00:00:00

  • Light and heavy chains specifying a human IgM kappa autoantibody to a T-cell receptor V beta-antigen.

    abstract：:Humans frequently produce serum IgM autoantibodies reactive with T-cell receptor beta chains at a determinant defined by peptides corresponding to the first complementarity determining region. It is likely that this determinant serves as a public idiotype involved in immunoregulation. Following screening of culture su...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(93)90010-y

    authors： Dedeoglu F,Kaymaz H,Klein G,Marchalonis JJ

    更新日期：1993-11-01 00:00:00

  • Fetal calf serum-primed dendritic cells induce a strong anti-fetal calf serum immune response and diabetes protection in the non-obese diabetic mouse.

    abstract：:In recent years, several investigators have shown that transfer of dendritic cells (DC) prevents diabetes development in non-obese diabetic (NOD) mice. Accumulating evidences showing that DC cultured in medium containing fetal calf serum (FCS) can induce a dominant unspecific immune response in tumor models after i.v....

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2006.11.007

    authors： Kadri N,Potiron N,Ouary M,Jegou D,Gouin E,Bach JM,Lieubeau B

    更新日期：2007-02-15 00:00:00

  • Mega-dose Vitamin C modulates T cell functions in Balb/c mice only when administered during T cell activation.

    abstract：:Previously we reported that a mega-dose of Vitamin C enhanced the initial stage of delayed-type hypersensitivity reaction in Balb/c mice. In this study its effects were further evaluated as follows. Mice were administered Vitamin C intraperitoneally at 0.625 mg/day or at 5mg/day for variable days before, during, or af...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2004.10.012

    authors： Noh K,Lim H,Moon SK,Kang JS,Lee WJ,Lee D,Hwang YI

    更新日期：2005-04-15 00:00:00

  • Cyclophilin A and an antibody against cyclosporin A resemble each other in their binding sites.

    abstract：:The three-dimensional structures of cyclosporin A complexed with cyclophilin A or Fab fragment of a monoclonal antibody were compared. In these two complexes conformations of the fragment D-alanine8-N-methylvaline11 in cyclosporin A were in a good agreement. In addition, cyclophilin A and the Fab fragment had related ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(94)90135-x

    authors： Denesyuk AI,Lundell J,Zav'yalov V,Korpela T

    更新日期：1994-07-01 00:00:00

  • CD8+ T-cell protective immunity induced by immunization with Plasmodium berghei CS protein-derived synthetic peptides: evidence that localization of peptide-specific CTLs is crucial for protection against malaria.

    abstract：:Immunization of BALB/c mice (H-2d) with a mixture of major histocompatibility complex (MHC) class I- and MHC class II-restricted synthetic peptides emulsified in incomplete Freund's adjuvant (IFA) induced a high level of specific cytotoxic T lymphocyte (CTL) activity. Peptides 249-260 or 252-260, derived from the circ...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(95)00043-5

    authors： Renggli J,Valmori D,Romero JF,Eberl G,Romero P,Betschart B,Corradin G

    更新日期：1995-05-01 00:00:00

  • Cell surface markers, inositol phosphate levels and membrane potential of lymphocytes from young and old human patients.

    abstract：:It is well known that most physiological functions change with aging, including the immune response. Data concerning the aging of lymphocyte subpopulations are conflicting. The antigen density of peripheral blood lymphocytes has been determined by fluorescently tagged OKT-3, OKT-4, OKT-8, OKT-11 and OKM1 monoclonal an...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(90)90072-x

    authors： Varga Z,Bressani N,Zaia AM,Bene L,Fülöp T,Leövey A,Fabris N,Damjanovich S

    更新日期：1990-02-01 00:00:00

  • Peptide-primed CD4+ cells and malaria sporozoites.

    abstract：:We have mapped a T cell epitope in the circumsporozoite (CS) protein of the murine malaria parasite, Plasmodium yoelii. A 21-mer synthetic peptide corresponding to the amino acid positions 59-79 (referred to as Py1), induced specific proliferation in BALB/c and C57BL/6 mice, and provided help for the production of ant...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(90)90092-5

    authors： Del Giudice G,Grillot D,Rénia L,Müller I,Corradin G,Louis JA,Mazier D,Lambert PH

    更新日期：1990-08-01 00:00:00

  • Combined association between IFN-gamma 3,3 homozygosity and DRB1*03 in Löfgren's syndrome patients.

    abstract：:In the present study, short tandem repeats (STR) polymorphism within the first intron of IFN-gamma gene in connection with HLA-DRB1*03 specificities was analysed in 43 sarcoidosis patients, 14 of which presented with Löfgren's syndrome (LS). Four out of 5 known IFN-gamma alleles with 12-15 CA repeats, respectively wer...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2003.11.005

    authors： Wysoczanska B,Bogunia-Kubik K,Suchnicki K,Mlynarczewska A,Lange A

    更新日期：2004-02-15 00:00:00

  • Cellular responses of guinea-pig macrophages to C4a; inhibition of C3a-induced O2- generation by C4a.

    abstract：:We have investigated the cellular responses of guinea-pig macrophages to human C4a. C4a induced a biphasic Ca2+ mobilization; a rapid temporary Ca2+ mobilization from intracellular Ca2+ pool followed by a weak Ca2+ influx of extracellular Ca2+. Although the C4a-treated macrophages did not respond again to C4a, that is...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(93)90104-a

    authors： Murakami Y,Yamamoto T,Imamichi T,Nagasawa S

    更新日期：1993-06-01 00:00:00

  • Considering genetic profiles in functional studies of immune responsiveness to HIV-1.

    abstract：:Over the last two decades HIV-1 has spread worldwide and has now surpassed malaria as the leading cause of infectious disease mortality in adults (http://www.who.int/infectious-disease-report/pages/ch1text.html). The clinical course and outcome of HIV-1 infection are highly variable among individuals. Most individuals...

    journal_title：Immunology letters

    pub_type： 杂志文章,评审

    doi：10.1016/s0165-2478(01)00275-9

    authors： Carrington M,Nelson G,O'Brien SJ

    更新日期：2001-11-01 00:00:00

  • Critical roles of the PI3K/Akt signaling pathway in T cell development.

    abstract：:Thymocyte development requires an integration of extracellular cues to enforce lineage commitment at multiple defined checkpoints in a stage-specific manner. Critical signals from the pre-TCR, Notch, and the receptor for interleukin-7 (IL-7) dictate cellular differentiation from the CD4(-)CD8(-) (double negative) stag...

    journal_title：Immunology letters

    pub_type： 杂志文章,评审

    doi：10.1016/j.imlet.2007.12.008

    authors： Juntilla MM,Koretzky GA

    更新日期：2008-03-15 00:00:00

  • Presentation of the Plasmodium falciparum antigen Pf155/RESA to human T cells. Variations in responsiveness induced by antigen presenting cells from different but MHC class II identical donors.

    abstract：:The antibody response in humans naturally primed to a malaria vaccine candidate antigen (Pf155/RESA) is genetically regulated. Here, the impact of antigen presenting cells (APC) on the control of in vitro T-cell responses induced by Pf155/RESA or synthetic peptides corresponding to its major Pf155/RESA epitopes was st...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(94)00163-4

    authors： Troye-Blomberg M,Lepers JP,Sjöberg K,Rahalimalala L,Larsson A,Olerup O,Perlmann P

    更新日期：1994-12-01 00:00:00

  • Homeostatic and functional analysis of mature B cells in lambda5-deficient mice.

    abstract：:The peripheral B-cell pool is in dynamic equilibrium and is controlled by a variety of factors. The rate of generation of B cells can influence both the composition and size of the peripheral B-cell compartment. Mice deficient for lambda5 gene expression have a block in early B-cell development leading to a markedly r...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2005.05.013

    authors： Harfst E,Andersson J,Grawunder U,Ceredig R,Rolink AG

    更新日期：2005-11-15 00:00:00

  • Pneumococcal pneumonia suppresses allergy development but preserves respiratory tolerance in mice.

    abstract：:Colonization with Streptococcus pneumoniae (S. pneumoniae) is associated with an increased risk for recurrent wheeze and asthma. Killed S. pneumoniae showed some potential as an effective immunomodulatory therapy in a murine model of asthma. Murine studies demonstrated protection against allergic asthma by symbiotic b...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2014.12.001

    authors： Hartmann C,Behrendt AK,Henken S,Wölbeling F,Maus UA,Hansen G

    更新日期：2015-03-01 00:00:00

  • Neuraminidase- and benzalkonium chloride-dependent inhibition of basic peptide-induced rat mast cell secretion.

    abstract：:Two types of inhibition of basic peptide-induced rat mast cell secretion are reported. Pretreatment of rat peritoneal mast cells with Vibrio comma neuraminidase, an enzyme which cleaves sialic acid from oligosaccharides, led to inhibition of 5-hydroxytryptamine release induced by the basic peptides polylysine, cortico...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(82)90134-1

    authors： Coleman JW

    更新日期：1982-10-01 00:00:00

  • Infectivity of Leishmania promastigotes is associated with surface antigenic expression.

    abstract：:Differentiation between a non-infective and an infective Leishmania promastigote population was demonstrated. Promastigotes in the stationary phase (day 5) were found to be highly infective in vitro to BALB/c mouse peritoneal macrophages, compared with those of the logarithmic phase (day 3). The infective promastigote...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/0165-2478(85)90114-2

    authors： Rizvi FS,Afchain D,Sherlock I,Sadigursky M,Capron A,Santoro F

    更新日期：1985-01-01 00:00:00

  • Adoptive transfer of mast cells does not enhance the impaired survival of Kit(W)/Kit(W-v) mice in a model of low dose intraperitoneal infection with bioluminescent Salmonella typhimurium.

    abstract：:Mast cells are important effector cells in IgE-associated immune responses, but also can contribute to host defense in certain examples of bacterial infection. We found that genetically mast cell-deficient WBB6F1-Kit(W)/Kit(W-v) mice exhibited more bacterial CFUs per spleen by 6 days after intraperitoneal injection of...

    journal_title：Immunology letters

    pub_type： 杂志文章

    doi：10.1016/j.imlet.2005.02.015

    authors： Chatterjea D,Burns-Guydish SM,Sciuto TE,Dvorak A,Contag CH,Galli SJ

    更新日期：2005-06-15 00:00:00