Cyclophilin A and an antibody against cyclosporin A resemble each other in their binding sites.


:The three-dimensional structures of cyclosporin A complexed with cyclophilin A or Fab fragment of a monoclonal antibody were compared. In these two complexes conformations of the fragment D-alanine8-N-methylvaline11 in cyclosporin A were in a good agreement. In addition, cyclophilin A and the Fab fragment had related arrangements of the aromatic amino acids in their binding sites, implying that antibody independently utilizes similar structural themes for binding cyclosporin A as cyclophilin A.


Immunol Lett


Immunology letters


Denesyuk AI,Lundell J,Zav'yalov V,Korpela T




Has Abstract


1994-07-01 00:00:00














  • Increased expression of neutral endopeptidase (NEP) and aminopeptidase N (APN) on peripheral blood mononuclear cells in patients with multiple sclerosis.

    abstract::We studied CD10 Ag of neutral endopeptidase (NEP) and CD13 Ag of aminopeptidase N (APN) expression on peripheral blood mononuclear cells (PBMC) as cells activation markers and for their transendothelial migration properties in three groups of MS patients (total 58); with acute exacerbation of MS (n = 18), primary prog...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Ziaber J,Baj Z,Paśnik J,Chmielewski H,Tchórzewski H

    更新日期:2000-02-01 00:00:00

  • Immunoreceptor tyrosine-based inhibition motif-bearing receptors regulate the immunoreceptor tyrosine-based activation motif-induced activation of immune competent cells.

    abstract::ITIM-bearing receptors, a family which only recently has been recognized, play a key role in the regulation of the ITAM-induced activation of immune competent cells. The mechanism of ITM-mediated regulation in various cells was recently clarified. The present review focuses on ITIM bearing membrane proteins that negat...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审


    authors: Gergely J,Pecht I,Sármay G

    更新日期:1999-05-03 00:00:00

  • Role of transmembrane domains in the functions of B- and T-cell receptors.

    abstract::The antigen receptors on the surface of B- and T-lymphocytes are complexes of several integral membrane proteins, essential for their proper expression and function. Recent studies demonstrated that transmembrane (TM) domains of the components of these receptors play a critical role in their association and function. ...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审


    authors: Zidovetzki R,Rost B,Pecht I

    更新日期:1998-12-01 00:00:00

  • Massive infiltration of basophilic cells in inflamed tissue after injection of RANTES.

    abstract::Regulated upon activation normal T expressed and secreted (RANTES) is a new inducible protein member of the human C-C branch of chemokines. RANTES is a potent monocyte and lymphocyte chemoattractant and is a mediator of inflammatory responses. In these studies we found that RANTES 10 ng/50 microl chemoattracts basophi...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Conti P,Reale M,Barbacane RC,Frydas S,Felaco M,Grilli A,Placido FC,Cataldo I,Feliciani C,Di Gioacchino M,Anogianakis G,Dimitriadou D,Vacalis D,Trakatellis A

    更新日期:1997-07-01 00:00:00

  • Interaction between serum amyloid A and leukocytes - a possible role in the progression of vascular complications in diabetes.

    abstract::Diabetes mellitus is associated with an increased incidence of cardiovascular events and microvascular complications. Serum amyloid A (SAA), a HDL apolipoprotein is a risk marker for cardiovascular disease. A permanent increase in SAA plasma levels is observed in diabetics. Because SAA acts on leukocytes, we evaluated...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Hatanaka E,Monteagudo PT,Marrocos MS,Campa A

    更新日期:2007-02-15 00:00:00

  • Phosphatidylinositol metabolism in lymphocytes of chronic alcoholic patients after anti-CD3 stimulation.

    abstract::The immunological alterations observed in chronic alcoholic patients may be due to alterations of signal transduction across the lymphocyte membrane. Upon binding of mitogens or antigens to specific plasma membrane receptors, the activation of phospholipase C leads to the hydrolysis of inositol phospholipids, producin...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Hrelia S,Celadon M,Bordoni A,Castelli E,Foschi FG,Stefanini GF,Rossi CA,Biagi PL

    更新日期:1995-05-01 00:00:00

  • Clinical laboratory standard capillary protein electrophoresis alerted of a low C3 state and lead to the identification of a Factor I deficiency due to a novel homozygous mutation.

    abstract::Complement factor I (CFI) deficiency is typically associated to recurrent infections with encapsulated microorganisms and, less commonly, to autoimmunity. We report a 53-years old male who, in a routine control for non-alcoholic fatty liver disease, presented a flat beta-2 fraction at the capillary protein electropher...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Franco-Jarava C,Colobran R,Mestre-Torres J,Vargas V,Pujol-Borrell R,Hernández-González M

    更新日期:2016-06-01 00:00:00

  • Neurotransmitters regulate the migration and cytotoxicity in natural killer cells.

    abstract::Natural killer (NK) cells and cytotoxic T lymphocytes (CTL), the functional coordination of which are governed by various signal substances, are crucial in the body's defense of tumor and virus-infected cells. We investigated the role of various neurotransmitters and hormones on the regulation of functional parameters...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Lang K,Drell TL,Niggemann B,Zänker KS,Entschladen F

    更新日期:2003-12-15 00:00:00

  • Modulation of proliferation, differentiation and cytokine secretion of murine B-1b cells by proteins of the extracellular matrix.

    abstract::At least three B cell subsets, B-1a (Ly-1B), B-1b and B-2, are present in the mouse periphery. B-1a and B1-b cells represent a small population in the adult spleen and are abundant in the peritonial and pleural cavities. It has been demonstrated in our laboratory that B-1b cells spontaneously proliferated in stationar...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Ferreira KS,Almeida SR,Ribeiro CH,Mariano M,Lopes JD

    更新日期:2003-03-03 00:00:00

  • Mycobacterial 3-hydroxyacyl-l-thioester dehydratase Y derived from Mycobacterium tuberculosis induces COX-2 expression in mouse macrophages through MAPK-NF-κB pathway.

    abstract::Tuberculosis (TB) is a leading cause of global mortality due to infectious diseases. Expression of cyclooxygenase-2 (COX-2) acts as an important influencing factor favoring bacillary survival during TB infection. In this study, we investigated the Mycobacterium tuberculosis proteins recognized by sera from TB patient ...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Zhao JW,Sun ZQ,Zhang XY,Zhang Y,Liu J,Ye J,Chen CC,Samten B,Wang HH,Guo XK,Zhang SL

    更新日期:2014-09-01 00:00:00

  • Cytokine-deficient mice as a model for generation of autologous anti-cytokine monoclonal antibodies.

    abstract::The possibility of inducing immune responses to murine interleukin-4 (IL-4) and IL-13 and generating anti-cytokine monoclonal antibodies (mAbs) was studied in IL-4- and IL-13-knockout mice. The minimal doses of IL-4 or IL-13 that could induce significant anti-cytokine responses with titers of 5000-10,000 were 20 micro...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Shichkin VP,Spivak NY

    更新日期:2006-02-15 00:00:00

  • TIM-1 regulates macrophage cytokine production and B7 family member expression.

    abstract::T-cell immunoglobulin mucin-1 (TIM-1) is associated with the regulation of T helper type 2 (Th2) immune responses and has been associated with asthma susceptibility. Previous studies have shown that administration of TIM-1 results in T cell hyperproliferation and increased Th2 cytokine secretion. TIM-1 has also been s...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Hein RM,Woods ML

    更新日期:2007-01-15 00:00:00

  • Multiple effects of human recombinant interleukin 4 on human myeloid monocyte cell lines.

    abstract::The effects of recombinant human interleukin 4 (rIL-4) on proliferation and differentiation on human myeloid/monocytic leukemia cell lines were examined. At high concentrations, rIL-4 had a slight enhancing effect on [3H]thymidine incorporation by U937 cells. rIL-4 markedly induced expression of the Fc epsilon recepto...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Noma T,Nakakubo H,Hama K,Honjo T

    更新日期:1989-06-15 00:00:00

  • Characterization of a cytotoxic factor produced by rat bladder cancer cell line: its identity to TNF alpha.

    abstract::Clone C19 derived from a rat bladder cancer cell line BC31ad constitutively released cytotoxic factor RCF. The serum-free C19-conditioned medium was partially purified by DEAE-Sephacel, Sephacryl S-200 and MonoQ-FPLC chromatographies to the specific activity of 6.4 x 10(6) U/mg protein (LM assay). RCF was a 17-kDa pro...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Hojo H,Kaneko A,Nanya K,Kayagaki N,Hashimoto Y

    更新日期:1994-06-01 00:00:00

  • Effect of intestinal epithelial cell cytokines on mucosal B-cell IgA secretion: enhancing effect of epithelial-derived IL-6 but not TGF-beta on IgA+ B cells.

    abstract::A variety of cell types may be involved in the regulation of IgA secretion at the intestinal mucosa. Intestinal epithelial cells (IEC) are known to have the capacity to secrete several cytokines which may exert an important regulatory effect on local immunoglobulin secretion by mucosal B cells. In this study, we have ...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Goodrich ME,McGee DW

    更新日期:1999-03-15 00:00:00

  • Global gene expression changes in type 1 diabetes: insights into autoimmune response in the target organ and in the periphery.

    abstract::Type 1 diabetes (T1D) is an autoimmune disease caused by the selective destruction of the insulin-producing β cells. Research into the pathogenesis of T1D has been hindered by the lack of detection of the autoimmune process during the asymptomatic period and by the inaccessibility to the target tissue. Therefore curre...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审


    authors: Planas R,Pujol-Borrell R,Vives-Pi M

    更新日期:2010-10-30 00:00:00

  • Identification of cytokines which enhance (CSF-1, IL-3) or restrict (IFN-gamma) growth of intramacrophage Listeria monocytogenes.

    abstract::Murine peritoneal macrophages were isolated by adherence and their listericidal activity assessed in the presence or absence of selected cytokines. Untreated macrophages were not highly listericidal, showing moderate killing in the first 2 h after infection, and allowed progressive microbial growth thereafter (up to 9...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Denis M,Gregg EO

    更新日期:1991-03-01 00:00:00

  • IL4 blockade of inducible regulatory T cell differentiation: the role of Th2 cells, Gata3 and PU.1.

    abstract::Naive CD4 T cells differentiate into functionally distinct T helper (Th) cells subsets or into regulatory T (Treg) cells in response to the cytokine milieu in which they encounter antigen. A recurring theme in post-thymic CD4 T cell differentiation is the cross-regulation of lineage choice by cytokines and transcripti...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Hadjur S,Bruno L,Hertweck A,Cobb BS,Taylor B,Fisher AG,Merkenschlager M

    更新日期:2009-01-29 00:00:00

  • SH2D1A expression reflects activation of T and NK cells in cord blood lymphocytes infected with EBV and treated with the immunomodulator PSK.

    abstract::We infected umbilical cord blood lymphocytes (CBL) with EBV in vitro. Analysis of the cell population in 3- and 6-day-old cultures showed a relative increase of B cells and outgrowth of B cells after prolonged culture period. The immunomodulator PSK was added to parallel cultures. In these cultures, B cell growth was ...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Liu A,Klein G,Bandobashi K,Klein E,Nagy N

    更新日期:2002-03-01 00:00:00

  • Modulation of human macrophage functions by gangliosides.

    abstract::In human tumors of neuroectodermal origin cell surface expression of individual gangliosides is either increased or decreased relative to comparable normal cells. We have previously shown that gangliosides shed from melanoma cells can immunomodulate T cell activity. Monocytes/macrophages (m/m) are known to play an imp...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Hoon DS,Jung T,Naungayan J,Cochran AJ,Morton DL,McBride WH

    更新日期:1989-03-01 00:00:00

  • Immunoselection screening methods for detection of the free heavy chains.

    abstract::Immunoselection screening methods were developed for the detection of the free heavy chain determinants of biological fluids. The optimal sensitivity range of the electrosyneresis and electroimmunoassay type methods lies between 400 ng and 2 micrograms/ml and between 3 micrograms and 1 mg/ml for immunoglobulins. The s...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Ottó S,Végh Z,Kocsis G

    更新日期:1984-01-01 00:00:00

  • The production of human monoclonal anti-MMTV antibodies by in vitro immunization with anti-idiotypic antibodies.

    abstract::We have previously reported the production of a series of human monoclonal antibodies reacting with mouse mammary tumor viral antigens as well as the human counterpart HuMTV antigen. Against two of these antibodies (B11 and 4.6/6), anti-idiotypic antibodies were generated, which appeared to be the internal image of vi...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Blank M,Smorodinsky IN,Keydar I,Chaitchik S,Shoenfeld Y

    更新日期:1991-04-01 00:00:00

  • FT-2 antigen for distinguishing lymphocyte subpopulations in the developing thymus.

    abstract::The surface phenotypes of lymphoid cells in the developing embryonic thymus were characterized by using monoclonal antibodies. FT-2 antigen thus defined was predominantly expressed on thymocytes in the earlier embryonic stages in all the inbred mouse strains tested. The immunofluorescence and immunoperoxidase tests in...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Takashi T,Kasai M,Tanaka N,Takahashi T,Tokunaga T

    更新日期:1985-01-01 00:00:00

  • Benazepril inhibited the NF-κB and TGF-β networking on LV hypertrophy in rats.

    abstract:PURPOSE:Benazepril, an angiotensin-converting enzyme (ACE) inhibitor, has been used to treat hypertension, congestive heart failure, and chronic renal failure. However, its biological activity and mechanism of action in inflammation are not fully identified. The present study was designed to determine the in vivo anti-...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Yan SH,Zhao NW,Zhu XX,Wang Q,Wang HD,Fu R,Sun Y,Li QY

    更新日期:2013-05-01 00:00:00

  • Immunogenicity of Sm32 synthetic peptides derived from the Schistosoma mansoni adult worm.

    abstract::The previously called "hemoglobinase" Sm32 molecule of the adult worm of Schistosoma mansoni was chemically synthesized in 22 polymeric peptides based on the t-boc strategy. Their immunogenicity was evaluated in rabbits to which a mixture of five to six peptides of 20 amino acids long were given in three doses with Fr...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Noya O,Alarcón de Noya B,Guzmán F,Bermúdez H

    更新日期:2003-09-08 00:00:00

  • Targeting antigens to murine and human M-cells with Aleuria aurantia lectin-functionalized microparticles.

    abstract::Neuraminidases act as a virulence factors for several pathogens that invade the human body through Peyer's patch M-cells. Because of the structural similarity of Aleuria aurantia lectin (AAL) to neuraminidases, we hypothesized that AAL might also target human M-cells. In an in vitro human M-cell co-culture model signi...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Roth-Walter F,Bohle B,Schöll I,Untersmayr E,Scheiner O,Boltz-Nitulescu G,Gabor F,Brayden DJ,Jensen-Jarolim E

    更新日期:2005-09-15 00:00:00

  • Novel intranasal pertussis vaccine based on bacterium-like particles as a mucosal adjuvant.

    abstract::Pertussis, or whooping cough, has recently reemerged as a major public health threat despite high levels of vaccination. The development of a novel pertussis vaccine, especially an intranasal (i.n.) vaccine is undoubtedly necessary, and mucosal adjuvants have been explored to enhance the immune response. In the presen...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Shi W,Kou Y,Jiang H,Gao F,Kong W,Su W,Xu F,Jiang C

    更新日期:2018-06-01 00:00:00

  • Post-translational control of chemokines: a role for decoy receptors?

    abstract::It is well-established that chemokines play a critical role in the orchestration of inflammation and immunity. Interactions between chemokines and their receptors are essential for the homing of specific subsets of leukocytes to their functional microenvironments. They also influence other diverse biological processes...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审


    authors: Comerford I,Nibbs RJ

    更新日期:2005-01-31 00:00:00

  • New B-cell CD molecules.

    abstract::B cells not only play a pivotal role in humoral immunity, but also are involved in a broad spectrum of immune responses, including antigen presentation and T-cell function regulation. The identification of cell-surface CD molecules derived from a series of Human Leukocyte Differentiation Antigens (HLDA) Workshops has ...

    journal_title:Immunology letters

    pub_type: 杂志文章


    authors: Matesanz-Isabel J,Sintes J,Llinàs L,de Salort J,Lázaro A,Engel P

    更新日期:2011-01-30 00:00:00

  • Regulation of tyrosine-containing activation motif-dependent cell signalling by Fc gamma RII.

    abstract::Crosslinking of the B-cell receptor (BCR) for antigen to low-affinity receptors for IgG (Fc gamma RII) inhibits B-cell activation induced by BCR aggregation. The cell-triggering properties of the BCR depend on tyrosine-containing activation motifs (TAM), in the intracytoplasmic domain of its Ig alpha and Ig beta subun...

    journal_title:Immunology letters

    pub_type: 杂志文章,评审


    authors: Daëron M,Malbec O,Latour S,Espinosa E,Pina P,Fridman WH

    更新日期:1995-01-01 00:00:00