Cyclophilin A and an antibody against cyclosporin A resemble each other in their binding sites.

Abstract:

:The three-dimensional structures of cyclosporin A complexed with cyclophilin A or Fab fragment of a monoclonal antibody were compared. In these two complexes conformations of the fragment D-alanine8-N-methylvaline11 in cyclosporin A were in a good agreement. In addition, cyclophilin A and the Fab fragment had related arrangements of the aromatic amino acids in their binding sites, implying that antibody independently utilizes similar structural themes for binding cyclosporin A as cyclophilin A.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Denesyuk AI,Lundell J,Zav'yalov V,Korpela T

doi

10.1016/0165-2478(94)90135-x

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

213-6

issue

2-3

eissn

0165-2478

issn

1879-0542

pii

0165-2478(94)90135-X

journal_volume

41

pub_type

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