Combined association between IFN-gamma 3,3 homozygosity and DRB1*03 in Löfgren's syndrome patients.

Abstract:

:In the present study, short tandem repeats (STR) polymorphism within the first intron of IFN-gamma gene in connection with HLA-DRB1*03 specificities was analysed in 43 sarcoidosis patients, 14 of which presented with Löfgren's syndrome (LS). Four out of 5 known IFN-gamma alleles with 12-15 CA repeats, respectively were detected in sarcoidosis patients. IFN-gamma 3,3 homozygosity was found to constitute a risk factor associating with LS manifestation (0.50 versus 0.19, OD = 4.18, P = 0.014). As expected, DRB1*03 prevailed in LS cases (9/14 versus 7/29, P = 0.014 LS versus non-LS cases and 9/14 versus 35/162, OD = 6.20, P = 0.001, LS patients versus controls). However, we also showed the presence of a combined association between DRB1*03 and IFN-gamma 3,3 in sarcoidosis (P = 0.017) and LS patients (P = 0.001).

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Wysoczanska B,Bogunia-Kubik K,Suchnicki K,Mlynarczewska A,Lange A

doi

10.1016/j.imlet.2003.11.005

subject

Has Abstract

pub_date

2004-02-15 00:00:00

pages

127-31

issue

2-3

eissn

0165-2478

issn

1879-0542

pii

S0165247803002591

journal_volume

91

pub_type

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