Abstract:
:In the present study, short tandem repeats (STR) polymorphism within the first intron of IFN-gamma gene in connection with HLA-DRB1*03 specificities was analysed in 43 sarcoidosis patients, 14 of which presented with Löfgren's syndrome (LS). Four out of 5 known IFN-gamma alleles with 12-15 CA repeats, respectively were detected in sarcoidosis patients. IFN-gamma 3,3 homozygosity was found to constitute a risk factor associating with LS manifestation (0.50 versus 0.19, OD = 4.18, P = 0.014). As expected, DRB1*03 prevailed in LS cases (9/14 versus 7/29, P = 0.014 LS versus non-LS cases and 9/14 versus 35/162, OD = 6.20, P = 0.001, LS patients versus controls). However, we also showed the presence of a combined association between DRB1*03 and IFN-gamma 3,3 in sarcoidosis (P = 0.017) and LS patients (P = 0.001).
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Wysoczanska B,Bogunia-Kubik K,Suchnicki K,Mlynarczewska A,Lange Adoi
10.1016/j.imlet.2003.11.005subject
Has Abstractpub_date
2004-02-15 00:00:00pages
127-31issue
2-3eissn
0165-2478issn
1879-0542pii
S0165247803002591journal_volume
91pub_type
杂志文章abstract::The effect of B cell depletion on the induction and severity of murine experimental autoimmune thyroiditis was investigated. Thirteen CBA mice were given repeated intraperitoneal doses of 700 micrograms purified rabbit anti-mouse Ig antibody from 24 hours to 8 weeks after birth. Controls were given normal rabbit IgG (...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(89)90063-1
更新日期:1989-01-15 00:00:00
abstract::In early seventies "natural killer (NK) cells", a third lymphocyte subset was discovered that revealed an unexpected ability to kill syngeneic and allogeneic tumor targets, thus emerging as the most potent non-specific cytotoxic cells in both human and mouse. Decades of research revealed the multifaceted nature of the...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2013.12.009
更新日期:2014-10-01 00:00:00
abstract::Natural killer (NK) cells and cytotoxic T lymphocytes (CTL), the functional coordination of which are governed by various signal substances, are crucial in the body's defense of tumor and virus-infected cells. We investigated the role of various neurotransmitters and hormones on the regulation of functional parameters...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2003.09.004
更新日期:2003-12-15 00:00:00
abstract::CD24 is an extensively glycosylated membrane protein that is linked to the membrane via a glycosyl-phosphatidylinositol (GPI)-anchor. In mice, CD24 is expressed by hematopoietic and non-hematopoietic cells. CD24-/- mice do not have gross immunological defects, but detailed analysis revealed strongly reduced responses ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.06.004
更新日期:2014-09-01 00:00:00
abstract::Idiopathic thrombocytopenic purpura (ITP) is an acquired autoimmune disorder. Both impaired platelet production and T cell-mediated effects play a role in ITP thrombocytopenia. A Th1 polarization of the immune response, up-regulation of Th17 cells and decreased number of Treg cells have been demonstrated in ITP patien...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.08.006
更新日期:2013-07-01 00:00:00
abstract::Naive CD4 T cells differentiate into functionally distinct T helper (Th) cells subsets or into regulatory T (Treg) cells in response to the cytokine milieu in which they encounter antigen. A recurring theme in post-thymic CD4 T cell differentiation is the cross-regulation of lineage choice by cytokines and transcripti...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2008.11.001
更新日期:2009-01-29 00:00:00
abstract::Type 1 diabetes (T1D) is an autoimmune disease caused by the selective destruction of the insulin-producing β cells. Research into the pathogenesis of T1D has been hindered by the lack of detection of the autoimmune process during the asymptomatic period and by the inaccessibility to the target tissue. Therefore curre...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2010.08.001
更新日期:2010-10-30 00:00:00
abstract::Molecular chaperones (heat shock proteins, Hsp-s) play a pleiotropic role in immunological functions. Hsp-s participate in the presentation of peptide antigens, folding of several immunologically important proteins, such as the MHC, and in the maintenance of the activation-competent conformation of key signaling molec...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2003.11.025
更新日期:2004-03-29 00:00:00
abstract::CD24 is a heavy glycosylated protein that is overexpressed in numerous cancer and cancer stem cells. It is involved in the development, invasion, and metastasis of the cancer cells. CD24 can be considered in targeted cancer therapy as a new target. Here, phage display technology was used for the identification of nove...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2017.08.028
更新日期:2017-10-01 00:00:00
abstract::In the H-2-incompatible donor-recipient combination (BALB/c----CBA/H) local administration of cyclosporin allows a 4-fold reduction in a single dose prolonging survival of heart tissue allografts. These results suggest that local administration of cyclosporin may be useful for certain grafts. ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90067-z
更新日期:1990-02-01 00:00:00
abstract::African swine fever (ASF) virus has been reported to infect cells of the monocyte family, probably macrophage-like cells, but there is variation in the apparent susceptibility of these cells. We have demonstrated that the phenotype and activity of porcine monocytic cells varies between different isolations and also up...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90136-p
更新日期:1993-07-01 00:00:00
abstract::A survey of the appearance of natural antibodies in C57BL/6 mice, measured by a complement-dependent cytotoxicity test against syngeneic radiation leukemia virus-induced lymphoma, was performed. Activity could be detected in sera from 5- to 14-month-old animals. This activity could be attributed mainly to IgM antibodi...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(81)90074-2
更新日期:1981-10-01 00:00:00
abstract:BACKGROUND:Previous studies have reported an association between polymorphisms in Il17A and IL17F genes and the prevalence of rheumatoid arthritis (RA) in Caucasian populations. The aim of the current study was to investigate that polymorphisms in both genes may affect RA susceptibility in the Tunisian population and t...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2017.01.013
更新日期:2017-03-01 00:00:00
abstract::Lyophilized bacterial lysates, which actively stimulate the immune response, are widely used as vaccines or 'biological response modifiers' in subjects with recurrent bacterial respiratory infections. Since vaccines are indicated in the absence or in the presence of a weak constitutive immune response activity, a bett...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(02)00290-0
更新日期:2003-03-03 00:00:00
abstract::NK-like T cells which express the NK1.1 molecule and CD3 (or TCR) of intermediate level (CD3int or TCRint cells) were recently demonstrated to be present in various immune organs, and to have NK-like cytotoxic activity against NK target cells. In this study, we investigated whether NK1.1- T cells could express NK1.1. ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(98)00014-5
更新日期:1998-04-01 00:00:00
abstract::A docile substrain of lymphocytic choriomeningitis virus (LCMV) causes a persistent infection in adult C3HeB mice and induces a severe autoimmune hemolytic anemia (AIHA) which is maximal around three weeks post infection (PI). Evaluations of serum immunoglobulin levels of these mice demonstrated grossly elevated IgG2a...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90126-9
更新日期:1992-02-15 00:00:00
abstract::The antischistosomal property of a short course of cyclosporin A (CsA), administered at the time of infection was demonstrated in the rat. In comparison with vehicle-treated controls, no schistosomes were recovered from CsA-treated animals, 18-19 days post infection. Flow cytometric analysis of blood and spleen lympho...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(88)90086-7
更新日期:1988-02-01 00:00:00
abstract::The assessment strategy for implementation of the Union of European Medical Specialists' (UEMS) Immunology curriculum is based on a combination of formative and summative assessments. The strategy comprises a combination of workplace-based assessments and knowledge-based assessments designed to ensure acquisition of k...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.05.010
更新日期:2009-06-30 00:00:00
abstract::The purpose of this study is to show that anti-Leu M1 antibody (anti-CD15), which has different staining characteristics in lymphoid and non-lymphoid cells, reacted against the surface antigen of a defined monoclonal B cell line. This antibody recognizes the sugar moiety, lacto-N-fucopentaose (LNF-III), which is linke...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(89)90153-3
更新日期:1989-11-01 00:00:00
abstract::BAFF deficiency in mice impairs B cell development beyond the transitional stage 1 in the spleen and thus severely reduces the size of follicular and marginal zone B cell compartments. Moreover, humoral immune responses in these mice are dramatically impaired. We now addressed the question whether the decrease in matu...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2010.03.007
更新日期:2010-06-15 00:00:00
abstract::Although several components of the microbial wall of gram-positive bacteria and fungi possess immunostimulatory properties, their pathogenetic role remains incompletely evaluated. The purpose of this study was to assess the basic immune status of patients susceptible to infections and their capability for cytokine pro...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.12.014
更新日期:2014-05-01 00:00:00
abstract:INTRODUCTION:Considering the role of interleukin (IL)-9 and IL-9-producing Th9 cells in pathogenesis of autoimmune diseases, this study aimed to evaluate serum IL-9 levels in patients with Behçet's disease (BD) compared to healthy subjects and to assess whether there is an association between serum IL-9 levels and dise...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2019.05.007
更新日期:2019-07-01 00:00:00
abstract::We have previously reported the production of a series of human monoclonal antibodies reacting with mouse mammary tumor viral antigens as well as the human counterpart HuMTV antigen. Against two of these antibodies (B11 and 4.6/6), anti-idiotypic antibodies were generated, which appeared to be the internal image of vi...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90128-w
更新日期:1991-04-01 00:00:00
abstract::Cysticercosis caused by Taenia solium is a very common disease in developing countries that seriously affects human health. Diagnosis can only be confirmed with the aid of computerized tomography or nuclear magnetic resonance (NMR) creating obvious difficulties for epidemiological studies. Reliable immunoassays employ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(99)00166-2
更新日期:2000-01-10 00:00:00
abstract::A direct role for delayed hypersensitivity in organized granuloma formation has been emphasized in the literature, but some clinical and experimental studies have suggested a more complicated relationship. In order to further evaluate T-cell function in cutaneous granulomatous inflammation, hepatic granulomas isolated...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(86)90021-0
更新日期:1986-11-17 00:00:00
abstract::Salmonella enterica serovars infect a broad range of mammalian hosts, including humans, causing both gastrointestinal and systemic diseases. Effective immune responses to Salmonella infections depend largely on CD4+ T cell activation by dendritic cells (DCs). Bacteria are internalised by intestinal DCs and respond by ...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2019.01.006
更新日期:2019-11-01 00:00:00
abstract::This study was to investigate the role of macrophage migration inhibitory factor (MIF) in mouse acute otitis media (AOM), we hypothesize that blocking MIF activity will relieve mouse AOM. A mouse AOM model was constructed by injecting lipopolysaccharide (LPS) into the middle ear of C57BL/6 mice through the tympanic me...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.07.013
更新日期:2014-11-01 00:00:00
abstract::Adult B-acute lymphoblastic leukemia (B-ALL) does not share the favorable prognosis seen in pediatric patients with the same disease. Less than 50% of patients experience long-term survival and for those adults over age 60, long-term survival is only 10%. At time of relapse, 5-year prognosis is a dismal 7%. Novel and ...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2016.02.014
更新日期:2016-04-01 00:00:00
abstract::Human Clq, a subcomponent of the first component of complement interacts with human fibronectin. Using ELISA methodology fixation of Clq to solid phase fibronectin, as well as fibronectin to solid phase Clq has been demonstrated. Cl in its native macromolecular form displays little reactivity for fibronectin, nor does...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(82)90075-x
更新日期:1982-01-01 00:00:00
abstract::The antibody response in humans naturally primed to a malaria vaccine candidate antigen (Pf155/RESA) is genetically regulated. Here, the impact of antigen presenting cells (APC) on the control of in vitro T-cell responses induced by Pf155/RESA or synthetic peptides corresponding to its major Pf155/RESA epitopes was st...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)00163-4
更新日期:1994-12-01 00:00:00