Abstract:
:The cellular source of murine LAIF detected by an indirect leukocyte adherence inhibition (LAI) assay using capillary tubes was investigated using non-inducing peritoneal cells (PC) from normal and spindle-cell sarcoma-bearing A/J mice. Cell populations containing greater than 95% T-cells, B-cells or macrophages were prepared from PC using a series of elimination and enrichment procedures. The in vitro incubation of enriched T-cell populations (less than 0.05% macrophages) from tumor-bearing mice with the specific soluble tumor antigen did not result in the release of detectable levels of LAIF; however, the addition of 10% normal isologous macrophages to the T-cells resulted in a significant release of LAIF. Enriched B-cell populations did not release LAIF either by themselves of when 10% normal isologous macrophages were added. Cell populations containing both T-cells and B-cells produced significant levels of LAIF, but only when suitable numbers of macrophages were present. Treatment with anti-Thy-1.2 alloantiserum and complement resulted in the abrogation of LAIF production by mixed cell populations. Using Lyt-1.2 and Lyt-2.2 alloantisera and complement to prepare either Lyt-1.2 or Lyt-2.2 depleted T-cell populations, it was found that the Lyt-1.2 subpopulation was responsible for the release of LAIF in this test system. LAIF was found to be effective in reducing the glass adherence of macrophages but not of T-cells or B-cells.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Myers WL,O'Keefe ML,Gregory Sdoi
10.1016/0165-2478(81)90005-5subject
Has Abstractpub_date
1981-11-01 00:00:00pages
277-82issue
5eissn
0165-2478issn
1879-0542pii
0165-2478(81)90005-5journal_volume
3pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1998-04-01 00:00:00
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更新日期:2017-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0165-2478(91)90172-7
更新日期:1991-08-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90092-3
更新日期:1992-06-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2013.12.009
更新日期:2014-10-01 00:00:00
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doi:10.1016/j.imlet.2005.07.001
更新日期:2006-01-15 00:00:00
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pub_type: 杂志文章
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journal_title:Immunology letters
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更新日期:2005-01-31 00:00:00
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journal_title:Immunology letters
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更新日期:1984-01-01 00:00:00
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更新日期:2000-01-10 00:00:00
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更新日期:2015-07-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(86)90122-7
更新日期:1986-08-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1991-09-01 00:00:00