Abstract:
:Donor-reactive memory T cells mediated accelerated rejection is known as a barrier to the survival of transplanted organs. We investigated the combination of different monoclonal antibodies (mAbs) and donor-specific transfusion (DST) in memory T cells-based adoptive mice model. In the presence of donor-reactive memory T cells, the mean survival time (MST) of grafts in the anti-CD40L/LFA-1/DST group was 49.8d. Adding anti-CD44/CD70 mAbs to anti-CD40L/LFA-1/DST treatment. The MST was more than 100 d (MST>100 d). Compared with anti-CD40L/LFA-1/DST group, anti-CD40L/LFA-1/CD44/CD70/DST group notably reduced the expansion of memory T cells, enhanced the proportion of CD4+Foxp3+ regulatory T cells (Tregs) and suppressed donor-specific responses. Our data suggest that anti-CD40L/LFA-1/CD44/CD70mAbs and DST can synergistically inhibit accelerated rejection mediated by memory T cells to induce long-lived heart allograft acceptance in mice.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Shao W,Chen J,Dai H,Peng Y,Wang F,Xia J,Thorlacius H,Zhu Q,Qi Zdoi
10.1016/j.imlet.2011.03.009subject
Has Abstractpub_date
2011-08-30 00:00:00pages
122-8issue
2eissn
0165-2478issn
1879-0542pii
S0165-2478(11)00096-4journal_volume
138pub_type
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journal_title:Immunology letters
pub_type: 杂志文章
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doi:10.1016/j.imlet.2006.01.005
更新日期:2006-05-15 00:00:00
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journal_title:Immunology letters
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journal_title:Immunology letters
pub_type: 信件
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更新日期:2009-09-22 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90103-9
更新日期:1987-02-01 00:00:00
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