Abstract：
:Drosophila has recently become a powerful model organism for studies of innate immunity. The cellular elements of innate immunity in Drosophila, the hemocytes, have been characterized by morphological criteria, molecular markers, and cell-type-specific immunological markers. Here we suggest that an MiET1 GFP-reporter element insertion in the untranslated region of a gene (l1-atilla) - expressed in a subset of hemocytes, the lamellocytes - allows in vivo investigations of lamellocyte differentiation and facilitates genetic screens.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Honti V,Kurucz E,Csordás G,Laurinyecz B,Márkus R,Andó Idoi
10.1016/j.imlet.2009.08.004subject
Has Abstractpub_date
2009-09-22 00:00:00pages
83-4issue
1-2eissn
0165-2478issn
1879-0542pii
S0165-2478(09)00207-7journal_volume
126pub_type
信件abstract：:Interleukin (IL)-17A is a cytokine that plays an important role in infectious, autoimmune, and inflammatory diseases. In this study, we found that TCRγδ(+)CD4(-)CD8(-) T cells, but not TCRαβ(+)CD4(+) T cells, are the primary producers of IL-17A in the genital tract of female mice in the steady-state condition. High mR...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2012.05.006
更新日期：2012-09-01 00:00:00
abstract：PURPOSE:Benazepril, an angiotensin-converting enzyme (ACE) inhibitor, has been used to treat hypertension, congestive heart failure, and chronic renal failure. However, its biological activity and mechanism of action in inflammation are not fully identified. The present study was designed to determine the in vivo anti-...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2013.05.005
更新日期：2013-05-01 00:00:00
abstract：:Interleukin-21 (IL-21) is a T cell-derived cytokine modulating T cell, B cell, and natural killer cell responses. To determine whether IL-21 contributes to pathologic processes, recombinant IL-21 receptor (R) fusion protein (rhIL-21R-Fc) was examined in mice models of autoimmune arthritis (collagen-induced arthritis)....
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.09.007
更新日期：2015-02-01 00:00:00
abstract：:Apoptosis markers and the rate of lymphocyte apoptosis were followed in the peripheral blood of HIV infected persons at various stages of disease. Our study suggests that the early increase in memory cells following therapy may also be due to a significant decrease in apoptosis in this subset. The intrinsic resistance...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00167-9
更新日期：1999-03-01 00:00:00
abstract：:In the present investigations we aimed to study the effect of Shigella sonnei lipopolysaccharide (LPS) on delayed type hypersensitivity (DTH) to non-bacterial antigen in CBA mice. These experiments showed that intraperitoneal injection of phenol-water extracted LPS and avirulent S. sonnei did not affect the level of D...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(01)00298-x
更新日期：2002-01-01 00:00:00
abstract：:Scid mice develop human EBV-positive B cell tumors after injection with EBV-transformed human B cells or peripheral blood lymphocytes from EBV-seropositive donors. Injection of cytotoxic T cell (CTL) lines, selectively expanded in vitro to recognize autologous EBV-transformed B cells, protected mice against developing...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(96)02602-8
更新日期：1996-09-01 00:00:00
abstract：:Thymocyte development requires an integration of extracellular cues to enforce lineage commitment at multiple defined checkpoints in a stage-specific manner. Critical signals from the pre-TCR, Notch, and the receptor for interleukin-7 (IL-7) dictate cellular differentiation from the CD4(-)CD8(-) (double negative) stag...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2007.12.008
更新日期：2008-03-15 00:00:00
abstract：:The murine pre-B-like cell line, 70Z /3, has been shown to undergo differentiation in response to supernatants derived from concanavalin-A (Con A) stimulated rat spleen cells or ultraviolet light treated P388D1 macrophage cell line. After culture for 24 h with supernatant factors, normally membrane IgM negative 70Z /3...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90085-3
更新日期：1984-01-01 00:00:00
abstract：:Malaria, a major endemic tropical disease, is caused by the infection of blood cells by Plasmodium protozoa. Most patients control their parasitemia by a not fully understood spleen-dependent mechanism. SDF-1alpha is a chemokine produced by stromal cells such as reticular spleen cells. Nitric oxide (NO) has several im...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2003.05.001
更新日期：2003-10-31 00:00:00
abstract：:CD103(+)CD11b(+) dendritic cells (DC) are the major migratory DC subset in the small intestine lamina propria (siLP) and their survival is dependent on the transcription factor interferon regulatory factor 4 (IRF4). Mice with a DC-specific deletion of irf4 (CD11c-cre.Irf4 mice) have reduced mucosal CD103(+)CD11b(+) DC...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.05.012
更新日期：2016-08-01 00:00:00
abstract：:Administration of cyclosporin A (CS-A; 25 mg/kg daily) to rats from the time of immunization with ovalbumin (OVA) in complete Freund's adjuvant abolished the production of anti-OVA antibodies, including IgE. Cyclophosphamide (Cy; 150 mg/kg) given 2 days before immunization also inhibited specific antibody production b...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90017-3
更新日期：1985-01-01 00:00:00
abstract：:Chagas' disease is accompanied by severe anemia and oxidative stress, which may contribute to mortality. In this study, we investigated the role of 5-lipoxygenase (5-LO) in the control of parasitism and anemia associated with oxidative damage of erythrocytes in experimental Trypanosoma cruzi infection. Wild-type C57BL...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.02.002
更新日期：2009-03-24 00:00:00
abstract：:While cases of silicosis are often complicated by various autoimmune disorders, patients with asbestosis develop malignant tumors such as lung cancer and malignant mesothelioma. These differences may derive from different biological effects, particularly on immunological cells, of silica and asbestos. To find differen...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.11.005
更新日期：2005-04-15 00:00:00
abstract：:In this study, we examined the cytokine production by human peripheral blood mononuclear cells (PBM) from recipients of orthotopic liver transplants which had been stimulated by donor-specific alloantigen. Levels of interleukin (IL)-2, IL-4, interferon (IFN)-gamma, IL-10 and transforming growth factor (TGF)-beta produ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00061-3
更新日期：1998-09-01 00:00:00
abstract：:It is widely known that mast cells and cytokine TNF-alpha are both involved in inflammatory reactions. Therefore, we have studied whether TNF-alpha can cause histamine secretion from human adenoidal and cutaneous mast cells. The experiments were performed in vitro on mast cells isolated from tissues by enzymatic dispe...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00115-6
更新日期：1997-12-01 00:00:00
abstract：:The inflammatory response plays an important role during the induction of several neonatal diseases. Previous studies have shown that during newborn infections, the natural imbalance between pro- and anti-inflammatory responses shifts toward the production of pro-inflammatory cytokines. In this study, we employed an a...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2015.12.004
更新日期：2016-02-01 00:00:00
abstract：:Corticotropin releasing hormone (CRH) is a major regulator of the stress response. This study examined whether CRH regulates interleukin-18 expression on microglia, BV2. Our data show that CRH enhanced IL-18 expression and significantly induced the secretion of functional IL-18 protein. Furthermore, CRH induced IL-18 ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.12.003
更新日期：2005-05-15 00:00:00
abstract：:In spite of impressive results in the treatment of acute lymphoblastic B cell leukemia (B-ALL) with chimeric antigen receptor (CAR) T cells, the clinical outcome of some hematological cancers like follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL) has not been very promising likely due to immunosuppressiv...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2020.04.005
更新日期：2020-07-01 00:00:00
abstract：:ITIM-bearing receptors, a family which only recently has been recognized, play a key role in the regulation of the ITAM-induced activation of immune competent cells. The mechanism of ITM-mediated regulation in various cells was recently clarified. The present review focuses on ITIM bearing membrane proteins that negat...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/s0165-2478(99)00024-3
更新日期：1999-05-03 00:00:00
abstract：:The intestinal immune system maintains a delicate balance between immunogenicity against invading pathogens and tolerance of the commensal microbiota and food antigens. Dendritic cells (DC) generate primary T-cell responses, and determine whether these responses are immunogenic or tolerogenic. The regulatory role of D...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2013.01.007
更新日期：2013-02-01 00:00:00
abstract：:Bisphenol A (BPA) is a widely used plasticizer, which came into focus because of its genotoxic and sensitizing potential. Besides its toxic properties, BPA is also well-known for its antioxidant chemical properties. This in vitro study investigated the interference of BPA with interferon-γ (IFN-γ)-induced tryptophan b...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2015.10.006
更新日期：2015-12-01 00:00:00
abstract：:Silicosis is clinically characterized not only by respiratory disorders but by immunological abnormalities such as the appearance of autoantibodies and complications of autoimmune diseases. Dysregulation of apoptosis, particularly in the Fas/Fas ligand (FasL) pathway, has been considered to play a role in the pathogen...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00177-2
更新日期：2000-05-01 00:00:00
abstract：:This study tested the hypothesis that the Vδ3 subset of human γδ T cells, like their Vδ2 counterparts, can influence differentiation, antibody secretion and cytokine production by B cells. Vδ3 T cells constitute a minor subset of peripheral blood lymphocytes but are enriched in the liver and gut and are expanded in pa...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2018.02.002
更新日期：2018-04-01 00:00:00
abstract：:The presence of specific glutamate receptors on T lymphocytes separated from normal human blood was investigated. Upon study of T lymphocytes interaction with [3H]glutamate the last one was found to bind specifically to these cells, Kd = 2.36 x 10(-7) M. Thirteen unlabelled compounds were tested as potential glutamate...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00086-2
更新日期：1997-08-01 00:00:00
abstract：:Naive CD4 T cells differentiate into functionally distinct T helper (Th) cells subsets or into regulatory T (Treg) cells in response to the cytokine milieu in which they encounter antigen. A recurring theme in post-thymic CD4 T cell differentiation is the cross-regulation of lineage choice by cytokines and transcripti...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2008.11.001
更新日期：2009-01-29 00:00:00
abstract：:Atopic dermatitis (AD) and allergic contact dermatitis (ACD) are common skin inflammatory conditions. B and T cells are strongly implicated in allergic contact hypersensitivity (CHS) conditions. Activation of IgD B-cell receptor (BCR) by anti-IgD stimulation depletes mature B cells and modulates T-helper cell type 1/2...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2018.09.008
更新日期：2018-11-01 00:00:00
abstract：:Using embryonic chickens treated with testosterone propionate, the effects of congenital absence of the bursa of Fabricius determined by the frequency of J chain-positive cells was examined in the spleen, thymus and bone marrow at the embryonic and newly hatched stages. J chain-positive cells in the chicks without bur...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90037-3
更新日期：1984-01-01 00:00:00
abstract：:Early diagnosis and immediately started appropriate treatment are mandatory for the prevention of radiographic progression, functional disability and unfavourable disease outcome in rheumatoid arthritis (RA). The current classification criteria for RA include two different types of biomarkers representing inflammatory...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2017.05.010
更新日期：2017-09-01 00:00:00
abstract：:The assessment strategy for implementation of the Union of European Medical Specialists' (UEMS) Immunology curriculum is based on a combination of formative and summative assessments. The strategy comprises a combination of workplace-based assessments and knowledge-based assessments designed to ensure acquisition of k...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.05.010
更新日期：2009-06-30 00:00:00
abstract：:A survey of the appearance of natural antibodies in C57BL/6 mice, measured by a complement-dependent cytotoxicity test against syngeneic radiation leukemia virus-induced lymphoma, was performed. Activity could be detected in sera from 5- to 14-month-old animals. This activity could be attributed mainly to IgM antibodi...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(81)90074-2
更新日期：1981-10-01 00:00:00
