Abstract:
:The presence of specific glutamate receptors on T lymphocytes separated from normal human blood was investigated. Upon study of T lymphocytes interaction with [3H]glutamate the last one was found to bind specifically to these cells, Kd = 2.36 x 10(-7) M. Thirteen unlabelled compounds were tested as potential glutamate competitors. It was shown that only quisqualate (a structural analogue of glutamate) and dipeptides Ala-Glu, Glu-Ala, Glu-Glu competed with [3H]glutamate in binding to a common binding site. The experiments on binding of labelled and unlabelled glutamate bulky conjugates with dextran have demonstrated that both conjugated and free glutamate interacted with the common binding sites on the outer cell membrane. By this means it was shown that T lymphocytes exposed quisqualate-sensitive glutamate receptors on the outer surface of the plasma membrane.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Kostanyan IA,Merkulova MI,Navolotskaya EV,Nurieva RIdoi
10.1016/s0165-2478(97)00086-2subject
Has Abstractpub_date
1997-08-01 00:00:00pages
177-80issue
3eissn
0165-2478issn
1879-0542pii
S0165-2478(97)00086-2journal_volume
58pub_type
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