Abstract：
:T cells recognize with a single receptor both a product of antigens processed by antigen presenting cells (APC1) and a self-marker molecule, encoded by the major histocompatibility complex (MHC, a property termed MHC-restricted recognition of antigen). During their differentiation in the thymus, T cells "learn" what to regard as self-MHC molecules, and only the cells once able to recognize antigen in the context of self-MHC will be "positively selected" to exit the thymus. The cells, once capable of reacting to self molecules, do not exit the thymus. They are "negatively selected" (deleted). Both "positive" and "negative" selection depends on the T-cell-receptor (TCR) specificity. Furthermore, the TCR specificity determines the final phenotype of the mature T cells; namely, the cells with receptors specific for the MHC-class I molecule will acquire the CD4-CD8+ phenotype, while the cells with receptors specific for the MHC-class II molecule will acquire the CD4+CD8- phenotype. However, a few mature T cells in the periphery do not follow the rule: CD4 expression class II restriction and CD8 expression class I restriction. We believe that these T lymphocytes have a receptor with very high affinity for one class of MHC molecules and cross-react with another class of MHC molecules (with somewhat lower affinity). The majority of T lymphocytes with such receptors bind the thymic MHC molecule, for which they have the highest affinity. Since this affinity is too high for further differentiation, such clones are deleted in the thymus. However, a small fraction of these cells bind the alternative class of MHC molecules, due to cross-reactivity of their receptors.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Marusić-Galesić S,Pavelić Kdoi
10.1016/0165-2478(90)90040-wsubject
Has Abstractpub_date
1990-06-01 00:00:00pages
149-54issue
3eissn
0165-2478issn
1879-0542pii
0165-2478(90)90040-Wjournal_volume
24pub_type
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更新日期：1996-06-01 00:00:00
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更新日期：2014-05-01 00:00:00
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pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2013-01-01 00:00:00
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pub_type： 杂志文章
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：2008-10-30 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：1997-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00126-0
更新日期：1998-01-01 00:00:00
