Variable effects of the co-administration of a GM-CSF-expressing plasmid on the immune response to flavivirus DNA vaccines in mice.

abstract：:Immunodeficiencies can lead to alterations of the gut microbiome that render it pathogenic and capable of transmitting disease to naïve hosts. Here, we review the role of Toll-like receptor (TLR) 5, the innate receptor for bacterial flagellin, in immune responses to the normal gut microbiota with a focus its role on a...

journal_title：Immunology letters

authors： Leifer CA,McConkey C,Li S,Chassaing B,Gewirtz AT,Ley RE

更新日期：2014-12-01 00:00:00

abstract：:CD8 T cells are strongly induced in response to certain strains of vaccinia virus (VACV) and the generation of this population is tightly regulated by two Tumor Necrosis Factor (TNF)/TNFR superfamily members, OX40 (CD134) and CD27. In this study, we examined the role of another member of the TNFR superfamily, 4-1BB (C...

journal_title：Immunology letters

authors： Zhao Y,Croft M

更新日期：2012-01-30 00:00:00

abstract：:A fragment of non-glycosylated E2 antigen of classical swine fever virus (CSFV), lacking the trans-membrane anchor (TM-) of the native glycoprotein, was produced in recombinant Escherichia coli strain BL21(DE3) in the form of inclusion bodies. These inclusion bodies isolated from the bacteria cells were administrated ...

journal_title：Immunology letters

authors： Kesik M,Saczyńska V,Szewczyk B,Płucienniczak A

更新日期：2004-02-15 00:00:00

abstract：:Recent advances in next-generation sequencing have enabled rapid and efficient evaluation of the mutational landscape of cancers. As a result, many cancer-specific neoantigens, which can generate antitumor cytotoxic T-cells inside tumors, have been identified. Previously, we reported a metastatic melanoma case with hi...

journal_title：Immunology letters

authors： Nonomura C,Otsuka M,Kondou R,Iizuka A,Miyata H,Ashizawa T,Sakura N,Yoshikawa S,Kiyohara Y,Ohshima K,Urakami K,Nagashima T,Ohnami S,Kusuhara M,Mitsuya K,Hayashi N,Nakasu Y,Mochizuki T,Yamaguchi K,Akiyama Y

更新日期：2019-04-01 00:00:00

abstract：:It is known that the receptors for the Fc portion of IgG molecules (Fc gamma R) are widely distributed in cells of the immune system. The expression of Fc gamma R enables monocytes and neutrophils to destroy antibody-coated target cells through the antibody-dependent cell-mediated cytotoxicity (ADCC) mechanism. In add...

journal_title：Immunology letters

authors： Isturiz MA,Geffner JR,Pizzolato MA

更新日期：1991-08-01 00:00:00

abstract：:N-Acetyl-l-cysteine (NAC) is a well-known medication, primarily used as a mucolytic agent in pulmonary disease. Recently, we have found that NAC possesses antipyretic properties. The aim of the present study was to investigate the mechanism by which NAC attenuates fever. The concentration of interleukin (IL)-10 and pr...

journal_title：Immunology letters

authors： Wrotek S,Jędrzejewski T,Piotrowski J,Kozak W

更新日期：2016-09-01 00:00:00

abstract：:Nervous and immune systems share specific recognition molecules for signals that originate in both systems. The information substances are polypeptides and their receptors. They comprise the multi-directional information exchange network whereby brain and nervous system function including mood and emotion can be integ...

journal_title：Immunology letters

authors： Wiedermann CJ

更新日期：1987-12-01 00:00:00

abstract：:In contrast to defibrinated blood, cells isolated from heparinized blood give lower T-lymphoproliferative responses. Such responses can be also suppressed by addition of heparin to lymphocyte cultures. Platelets inhibit T cell proliferation and B cell differentiation, but their interactions with heparin may produce co...

journal_title：Immunology letters

authors： Górski A,Wasik M,Stepień-Sopniewska B,Glapiński T

更新日期：1991-05-01 00:00:00

abstract：:Herein, we summarize the steps of a common scientific path taken by the two Guest Editors, an Anesthesiologist (EA) and an Immunologist (AS), and started 25 years ago at the National Cancer Institute in Rome. When in 1980 WHO codified the usage of opioids for cancer pain relief, it was matter of debate whether only di...

journal_title：Immunology letters

authors： Santoni A,Arcuri E

更新日期：2020-10-01 00:00:00

abstract：:In addition to expressing inhibitory cytokines and suppressive molecules, Treg cells could downplay inflammation by releasing cytotoxic molecules and eliminating proinflammatory immune cells. Colorectal cancer (CRC) is a common malignancy that has led to many cancer-related deaths. In this study, we investigated the c...

journal_title：Immunology letters

authors： Sun B,Liu M,Cui M,Li T

更新日期：2020-01-01 00:00:00

abstract：:Several recent studies have shown that the antigen receptors (mIgM and mIgD) on normal B cell surfaces are part of larger multimolecular complexes, as each is noncovalently coupled to at least two other proteins whose phosphorylation is inducible upon G protein activation. However, B cell receptor complexes appear to ...

journal_title：Immunology letters

authors： Chang CC,Alhasan S,Rosenspire AJ

更新日期：1992-05-01 00:00:00

abstract：:This study tested the hypothesis that the Vδ3 subset of human γδ T cells, like their Vδ2 counterparts, can influence differentiation, antibody secretion and cytokine production by B cells. Vδ3 T cells constitute a minor subset of peripheral blood lymphocytes but are enriched in the liver and gut and are expanded in pa...

journal_title：Immunology letters

authors： Petrasca A,Melo AM,Breen EP,Doherty DG

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:Benazepril, an angiotensin-converting enzyme (ACE) inhibitor, has been used to treat hypertension, congestive heart failure, and chronic renal failure. However, its biological activity and mechanism of action in inflammation are not fully identified. The present study was designed to determine the in vivo anti-...

journal_title：Immunology letters

authors： Yan SH,Zhao NW,Zhu XX,Wang Q,Wang HD,Fu R,Sun Y,Li QY

更新日期：2013-05-01 00:00:00

abstract：:Cysticercosis caused by Taenia solium is a very common disease in developing countries that seriously affects human health. Diagnosis can only be confirmed with the aid of computerized tomography or nuclear magnetic resonance (NMR) creating obvious difficulties for epidemiological studies. Reliable immunoassays employ...

journal_title：Immunology letters

authors： Hernández M,Beltrán C,García E,Fragoso G,Gevorkian G,Fleury A,Parkhouse M,Harrison L,Sotelo J,Sciutto E

更新日期：2000-01-10 00:00:00

abstract：:Common γ chain (γC) cytokines, namely IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 are important for the proliferation, differentiation, and survival of lymphocytes that display antitumor activity, thus stimulating considerable interest for the use of cytokines in cancer immunotherapy. In this review, we will focus on the...

journal_title：Immunology letters

authors： Pulliam SR,Uzhachenko RV,Adunyah SE,Shanker A

更新日期：2016-01-01 00:00:00

abstract：:Malaria vaccine development has traditionally concentrated on careful molecular, biochemical, and immunological characterisation of candidate antigens. In contrast, evidence of the importance of identified antigens in immunity to human infection and disease has generally been limited to statistically significant co-va...

journal_title：Immunology letters

authors： Staalsoe T,Jensen AT,Theander TG,Hviid L

更新日期：2002-11-01 00:00:00

abstract：:Although there is growing evidence that NKT cells play an important role in various immune responses through the invariant T cell receptor, other cell surface molecules responsible for their function are not fully understood. Here we study the role of ICOS, the third member of the CD28 family of costimulatory receptor...

journal_title：Immunology letters

authors： Watanabe S,Ohnuki K,Hara Y,Ishida Y,Ikarashi Y,Ogawa S,Kishimoto H,Tanabe K,Abe R

更新日期：2010-01-18 00:00:00

abstract：:Foxp3+ Regulatory T cells (Tregs) are essential for the maintenance of tolerance to self. Therefore, it is expected that lower numbers and/or less than optimal function could impact on the functioning of the immune system, and thereby contributing to the development of autoimmune diseases. In the present report, by co...

journal_title：Immunology letters

authors： Godoy GJ,Paira DA,Olivera C,Breser ML,Sanchez LR,Motrich RD,Rivero VE

更新日期：2020-07-01 00:00:00

abstract：:Dendritic cells (DCs) are professional antigen presenting cells, well equipped to initiate an immune response. For effective induction of an immune response, DC should migrate from the periphery to the lymph node to present the antigen to T lymphocytes. Currently, tumor-antigen loaded DCs are used in clinical vaccinat...

journal_title：Immunology letters

authors： Eggert AA,van der Voort R,Torensma R,Moulin V,Boerman OC,Oyen WJ,Punt CJ,Diepstra H,de Boer AJ,Figdor CG,Adema GJ

更新日期：2003-10-09 00:00:00

abstract：:Antisera were raised in rabbits against a monoclonal antibody (McAb 103) of C3H.SW origin which is specific to the synthetic polypeptide (T,G)-A-L and was shown to express the major idiotypic determinants of conventional anti-(T,G)-A-L antibodies. Antibodies were purified and were shown in a binding assay to recognize...

journal_title：Immunology letters

authors： Axelrod O,Stanislawski M,Mozes E

更新日期：1985-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is a debilitating neurological disorder of the central nervous system (CNS), characterized by activation and infiltration of leukocytes and dendritic cells into the CNS. In the initial phase of MS and its animal model, experimental autoimmune encephalomyelitis (EAE), peripheral macrophages infi...

journal_title：Immunology letters

authors： Jiang Z,Jiang JX,Zhang GX

更新日期：2014-07-01 00:00:00

abstract：:We investigated IgE-mediated allergic responses in a metabolic syndrome model rat strain, SHRSP.Z, which develops obesity and hypertension to cast light on the relationship between metabolic disturbances and allergic responses. IgE-mediated cutaneous anaphylactic responses were severely attenuated in this strain regar...

journal_title：Immunology letters

authors： Sakanaka M,Furuta K,Ichikawa A,Tanaka S

更新日期：2010-01-18 00:00:00

abstract：:Liposome-encapsulated conalbumin (L(conalbumin)) is an antigen that is efficiently phagocytosed by bone marrow-derived macrophages and presented to effector cells as part of the major histocompatibility complex (MHC) class I complex. In this report, we show that the conalbumin component of L(conalbumin) is degraded to...

journal_title：Immunology letters

authors： Rothwell SW,Wassef NM,Alving CR,Rao M

更新日期：2000-10-03 00:00:00

abstract：:The assessment strategy for implementation of the Union of European Medical Specialists' (UEMS) Immunology curriculum is based on a combination of formative and summative assessments. The strategy comprises a combination of workplace-based assessments and knowledge-based assessments designed to ensure acquisition of k...

journal_title：Immunology letters

authors： Choremi-Papadopoulou E,Faure GC,Malenica B,Misbah SA,Zlabinger GJ

更新日期：2009-06-30 00:00:00

abstract：:The presence of specific glutamate receptors on T lymphocytes separated from normal human blood was investigated. Upon study of T lymphocytes interaction with [3H]glutamate the last one was found to bind specifically to these cells, Kd = 2.36 x 10(-7) M. Thirteen unlabelled compounds were tested as potential glutamate...

journal_title：Immunology letters

authors： Kostanyan IA,Merkulova MI,Navolotskaya EV,Nurieva RI

更新日期：1997-08-01 00:00:00

abstract：:Both CD8 and CD2 are T cell surface receptors involved in physical cell interaction and in transmembrane signalling. The present paper addresses their role in the induction of two different functions of the cloned murine cytotoxic T cell C196: target cell lysis and IFN-gamma production. These functions were induced in...

journal_title：Immunology letters

authors： Reimann A,Ehrfeld A,Kupsch J,Maier B,Saizawa KM,Clinchy B,Eichmann K

更新日期：1991-10-01 00:00:00

abstract：:The carboxy-terminus of the major merozoite surface protein of Plasmodium has been shown to be the target of protective immunity in a number of non-vivax malaria parasite species. In an effort to develop a protective vaccine for Plasmodium vivax, the most prevalent form of human malaria, we expressed in Saccharomyces ...

journal_title：Immunology letters

authors： Kaslow DC,Kumar S

更新日期：1996-07-01 00:00:00

abstract：:Rheumatic fever (RF) and chronic rheumatic heart disease (RHD) are complications of oropharyngeal infection caused by Streptococcus pyogenes. Despite the importance of the complement system against infections and autoimmunity diseases, studies on the role of the lectin pathway in RF and RHD are scarce. Thus, our aim w...

journal_title：Immunology letters

authors： Catarino SJ,Andrade FA,Bavia L,Guilherme L,Messias-Reason IJ

更新日期：2021-01-01 00:00:00

abstract：:Our previous studies had shown that the clinicopathological spectrum in leprosy was associated with discrete T cell subsets in circulation, with tuberculoid patients having antigen-induced Th 1, whereas lepromatous leprosy patients with antigen-specific T cell anergy possessed Th 2 cells. The present study shows that ...

journal_title：Immunology letters

authors： Misra N,Selvakumar M,Singh S,Bharadwaj M,Ramesh V,Misra RS,Nath I

更新日期：1995-12-01 00:00:00

abstract：AIM:To develop new approach for tumor immunotherapy with VEGFR2-based DNA vaccine. METHODS:VEGFR2 derived from different species were prepared by RT-PCR and subjected to recombinant constructs. The chimeric gene of VEGFR2 was prepared by integrating different epitopes in different species. By transfecting into cells, ...

journal_title：Immunology letters

authors： Yan J,Jia R,Song H,Liu Y,Zhang L,Zhang W,Wang Y,Zhu Y,Yu J

更新日期：2009-09-22 00:00:00