Abstract：
:Antisera were raised in rabbits against a monoclonal antibody (McAb 103) of C3H.SW origin which is specific to the synthetic polypeptide (T,G)-A-L and was shown to express the major idiotypic determinants of conventional anti-(T,G)-A-L antibodies. Antibodies were purified and were shown in a binding assay to recognize McAb 103 as well as C3H.SW anti-(T,G)-A-L antibodies. C57BL/6 mice were immunized with the purified rabbit anti-McAb 103 (Ra 103) and their lymph nodes were studied in a proliferation assay. Proliferation was observed in the presence of both Ra 103 and (T,G)-A-L, although the latter stimulated the cells to a lesser extent, suggesting the induction in vivo of (T,G)-A-L-specific clones in low frequency. A T cell line was established from these lymph node cells. The line is kept in continuous growth in the presence of IL-2 and periodic triggering with Ra 103. A significant proliferative response was obtained with Ra 103 only. This proliferation could be almost completely inhibited by either McAb 103 or by conventional anti-(T,G)-A-L antibodies of C3H.SW origin, indicating the cross reaction between the idiotypes expressed on the T cell line and the (T,G)-A-L-specific antibodies. No proliferation could be detected in the presence of either normal rabbit IgG or rabbit anti-mouse IgG. Thus, the T cell line TId 103 allows the analysis of the role of idiotype in T cell recognition and regulation.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Axelrod O,Stanislawski M,Mozes Edoi
10.1016/0165-2478(85)90130-0subject
Has Abstractpub_date
1985-01-01 00:00:00pages
347-52issue
6eissn
0165-2478issn
1879-0542pii
0165-2478(85)90130-0journal_volume
10pub_type
杂志文章abstract：:Malaria, a major endemic tropical disease, is caused by the infection of blood cells by Plasmodium protozoa. Most patients control their parasitemia by a not fully understood spleen-dependent mechanism. SDF-1alpha is a chemokine produced by stromal cells such as reticular spleen cells. Nitric oxide (NO) has several im...
journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：2003-10-31 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：1997-11-01 00:00:00
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journal_title：Immunology letters
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更新日期：1990-08-01 00:00:00
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journal_title：Immunology letters
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更新日期：1982-01-01 00:00:00
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journal_title：Immunology letters
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更新日期：2005-09-15 00:00:00
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journal_title：Immunology letters
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更新日期：1997-06-01 00:00:00
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journal_title：Immunology letters
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journal_title：Immunology letters
pub_type： 杂志文章,评审
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更新日期：2002-11-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：1999-05-03 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90092-7
更新日期：1987-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.10.011
更新日期：2016-12-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.11.009
更新日期：2017-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(96)02655-7
更新日期：1996-12-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.10.018
更新日期：2006-02-28 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2014.03.006
更新日期：2014-07-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：2017-08-01 00:00:00
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journal_title：Immunology letters
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更新日期：2016-11-01 00:00:00
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journal_title：Immunology letters
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更新日期：2017-10-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(03)00071-3
更新日期：2003-08-05 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2020.01.007
更新日期：2020-04-01 00:00:00
abstract：:Normal and tumor-bearing host (TBH) peritoneal macrophage (M phi) responses to in vitro lipopolysaccharide (LPS) treatment were measured by assessing functional and phenotypic changes. Both normal and TBH untreated M phi suppressed mixed lymphocyte reaction (MLR) reactivity at all concentrations. Normal host M phi tre...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90031-k
更新日期：1990-03-01 00:00:00
abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective way to cure hematological malignancies. However, graft-versus-host disease (GVHD) following transplantation limits the clinical application to some extent. The donor T lymphocytes play a central role in the occurrence and development of GVH...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2011.01.010
更新日期：2011-05-01 00:00:00
abstract：:The Nramp1 gene was originally described as Ity/Lsh/Bcg, a single gene controlling resistance and susceptibility of inbred mice to a range of intramacrophage pathogens. Functional studies demonstrated that Ity/Lsh/Bcg had multiple pleiotropic effects on macrophage activation pathways, broadening interest in the gene t...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00127-8
更新日期：1999-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2015.05.002
更新日期：2015-07-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(99)00143-1
更新日期：1999-12-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2010.09.019
更新日期：2011-01-30 00:00:00
abstract：:It is well known that most physiological functions change with aging, including the immune response. Data concerning the aging of lymphocyte subpopulations are conflicting. The antigen density of peripheral blood lymphocytes has been determined by fluorescently tagged OKT-3, OKT-4, OKT-8, OKT-11 and OKM1 monoclonal an...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90072-x
更新日期：1990-02-01 00:00:00
