Abstract：
:We have previously reported that the capacity of highly malignant B16BL6 murine melanoma cells to induce cell death in naive syngeneic lymphocytes stems from the absence of major histocompatibility complex (MHC) class I glycoproteins in these melanoma cells. Our present study provides evidence that the above-mentioned lymphocidic activities of B16BL6 cells are selectively attenuated when the expression of H-2K (but not H-2D or H-2L) MHC class I glycoproteins is reconstituted in these cells. The induction of apoptosis in naive lymphocytes by H-2K-deficient melanoma cells does not involve the Fas ligand (Fas-L)/FAS signaling module, as demonstrated by employing lymphocytes derived from Fas-L(gld)- or Fas(lpr)-deficient mice in co-culture experiments. Furthermore, these tumor cells fail to induce Fas-L-mediated fratricide in co-cultured lymphocytes and do not express Fas-L either when grown alone or co-cultured with lymphocytes. These findings explain the previously widely reported selective down-regulation of certain MHC class I-encoded glycoproteins (H-2K, bur not H-2D or H-2L) during tumor progression. Namely, the initiation of an effective immune response against H-2K-deficient cells could be abrogated at very early steps, as the result of the induction of Fas-L/Fas-independent cell death among naive lymphoid cells.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Kellman-Pressman S,Fishman D,Tsory S,Segal Sdoi
10.1016/j.imlet.2005.03.016subject
Has Abstractpub_date
2005-09-15 00:00:00pages
146-52issue
2eissn
0165-2478issn
1879-0542pii
S0165-2478(05)00068-4journal_volume
100pub_type
杂志文章abstract：:T helper17 (Th17) cells have been demonstrated to participate in the pathogenesis of hepatitis B virus (HBV) associated liver damage. However, the contribution of Th17 cells to immune activation and disease aggravation in patients with HBV infection is not fully clear. In this study, we investigated the Th17 cells fre...
journal_title：Immunology letters
pub_type： 临床试验,杂志文章,多中心研究
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pub_type： 杂志文章
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journal_title：Immunology letters
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journal_title：Immunology letters
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2005-06-15 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：1981-04-01 00:00:00
